PMID- 17563559

OWN - NLM
STAT- MEDLINE
DCOM- 20070802
LR - 20171116
IS - 0263-6352 (Print)
IS - 0263-6352 (Linking)
VI - 25
IP - 7
DP - 2007 Jul
TI - CYBA C242T gene polymorphism and flow-mediated vasodilation in a population
of
young adults: the Cardiovascular Risk in Young Finns Study.
PG - 1381-7
AB - OBJECTIVE: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is a
major
source of the superoxide anion that contributes to decreased nitric oxide
bioavailability in the vasculature. The C242T polymorphism of the CYBA gene
that
encodes p22phox, a component of NADPH oxidase, has been found to modulate
superoxide production. We examined the relationship of the C242T polymorphism
with endothelial-dependent brachial artery flow-mediated vasodilatation (FMD)
in
a population-based sample of young healthy adults. METHODS: FMD, defined as
the
increased percentage in brachial artery diameter after reactive hyperemia,
was
assessed by ultrasound and the C242T polymorphism using a 5' nuclease assay
in
2058 subjects aged 24-39 years. RESULTS: The mean values of brachial artery
FMD
were 8.0 +/- 4.4% in all study subjects (n = 2058), and 7.8 +/- 4.4, 8.2 +/-
4.5,
and 8.7 +/- 4.5% in subjects with the CC (n = 1362), CT (n = 616), and TT (n
=
80) genotypes of the C242T CYBA polymorphism, respectively (P = 0.02 for
trend).
The association remained significant (P = 0.019) in multivariate analyses
adjusted for age, sex, obesity indices, smoking habits, blood pressure, serum
glucose, lipids, and C-reactive protein. The relationship between FMD and the
C242T polymorphism was stronger (P = 0.004) in overweight subjects (body mass
index > or = 25 kg/m, n = 895) and ever-smokers (P = 0.008, n = 1082),
whereas no
relationship was found in normal-weight subjects and non-smokers (P = 0.824
and P
= 0.438, respectively). CONCLUSION: The C242T polymorphism of the CYBA gene
seems
to be related to endothelial function in a population-based sample of young
healthy adults. Overweight and smoking status may modify this genetic effect.
FAU - Fan, Meng
AU - Fan M
AD - Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry,
Finland. meng.fan@uta.fi
FAU - Raitakari, Olli T
AU - Raitakari OT
FAU - Kähönen, Mika
AU - Kähönen M
FAU - Juonala, Markus
AU - Juonala M
FAU - Hutri-Kähönen, Nina
AU - Hutri-Kähönen N
FAU - Marniemi, Jukka
AU - Marniemi J
FAU - Rontu, Riikka
AU - Rontu R
FAU - Pörsti, Ilkka
AU - Pörsti I
FAU - Viikari, Jorma
AU - Viikari J
FAU - Lehtimäki, Terho
AU - Lehtimäki T
LA - eng
PT - Journal Article
PT - Multicenter Study
PT - Research Support, Non-U.S. Gov't
PL - England
TA - J Hypertens
JT - Journal of hypertension
JID - 8306882
RN - EC 1.6.3.- (NADPH Oxidases)
RN - EC 1.6.3.1 (CYBA protein, human)
SB - IM
MH - Adult
MH - Brachial Artery/diagnostic imaging/physiopathology
MH - Endothelium, Vascular/*physiopathology
MH - Female
MH - Finland
MH - Genotype
MH - Humans
MH - Hyperemia/complications/diagnostic imaging/physiopathology
MH - Male
MH - NADPH Oxidases/*genetics/metabolism
MH - *Polymorphism, Single Nucleotide
MH - Prospective Studies
MH - Regional Blood Flow
MH - Risk Factors
MH - Ultrasonography
MH - Vasodilation/*genetics
EDAT- 2007/06/15 09:00
MHDA- 2007/08/03 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/08/03 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - 00004872-200707000-00013 [pii]
AID - 10.1097/HJH.0b013e32810bfe58 [doi]
PST - ppublish
SO - J Hypertens. 2007 Jul;25(7):1381-7. doi: 10.1097/HJH.0b013e32810bfe58.