PMID- 29310573

OWN - NLM
STAT- MEDLINE
DCOM- 20180725
LR - 20211204
IS - 1471-2261 (Electronic)
IS - 1471-2261 (Linking)
VI - 18
IP - 1
DP - 2018 Jan 8
TI - Association of rs662799 in APOA5 with CAD in Chinese Han population.
PG - 2
LID - 10.1186/s12872-017-0735-7 [doi]
LID - 2
AB - BACKGROUND: CAD (Coronary Artery Disease) is a complex disease that
influenced by
various environmental and genetic factors. Previous studies have found many
single nucleotide polymorphisms (SNPs) associated with the risk of CAD
occurrence. However, the results are inconsistent. In this study, we aim to
investigate genetic etiology in Chinese Han population by analysis of 7 SNPs
in
lipid metabolism pathway that previously has been reported to be associated
with
CAD. METHODS: A total of 631 samples were used in this study, including 435
CAD
cases and 196 normal healthy controls. SNP genotyping were conducted via
multiplex PCR amplifying followed by NGS (next-generation sequencing).
RESULTS:
Rs662799 in APOA5 (Apolipoprotein A5) gene was associated with CAD in Chinese
Han
population (Odds-ratio = 1.374, P-value = 0.03). No significant association was
observed between the rest of SNPs and CAD. Stratified association analysis
revealed rs5882 was associated with CAD in non-hypertension group
(Odds-ratio = 1.593, P-value = 0.023). Rs1800588 was associated with CAD in
smoking group (Odds-ratio = 1.603, P-value = 0.035). CONCLUSION: The minor
allele
of rs662799 was the risk factor of CAD occurrences in Chinese Han population.
FAU - Chen, Hua
AU - Chen H
AUID- ORCID: 0000-0001-9140-5019
AD - Department of Cardiology, Southern Medical University, Guangzhou, Guangdong,
China.
AD - Department of Cardiology, Inner Mongolia People's Hospital, Huhehaote, Inner
Mongolia, China.
FAU - Ding, Shifang
AU - Ding S
AD - Department of Cardiology, Southern Medical University, Guangzhou, Guangdong,
China. dsfmdwh@163.com.
AD - Department of Cardiology, Wuhan General Hospital of Guangzhou Military
Region,
NO.627, Wuyue Road, Wuhan City, Hubei Province, China. dsfmdwh@163.com.
FAU - Zhou, Mi
AU - Zhou M
AD - Department of Cardiology, Southern Medical University, Guangzhou, Guangdong,
China.
FAU - Wu, Xiayin
AU - Wu X
AD - Department of Cardiology, Inner Mongolia Medical University, Huhehaote, Inner
Mongolia, China.
FAU - Liu, Xi
AU - Liu X
AD - Department of Cardiology, Inner Mongolia People's Hospital, Huhehaote, Inner
Mongolia, China.
FAU - Wu, Yun
AU - Wu Y
AD - Department of Cardiology, Inner Mongolia People's Hospital, Huhehaote, Inner
Mongolia, China.
FAU - Liu, Dechao
AU - Liu D
AD - Department of Cardiology, Inner Mongolia Medical University, Huhehaote, Inner
Mongolia, China.
LA - eng
GR - 2014CFA066/Natural Science Foundation of Hubei Province/International
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
DEP - 20180108
TA - BMC Cardiovasc Disord
JT - BMC cardiovascular disorders
JID - 100968539
RN - 0 (APOA5 protein, human)
RN - 0 (Apolipoprotein A-V)
SB - IM
MH - Aged
MH - Apolipoprotein A-V/*genetics
MH - Asians/genetics
MH - Case-Control Studies
MH - Chi-Square Distribution
MH - China/epidemiology
MH - Coronary Artery Disease/diagnosis/ethnology/*genetics
MH - Female
MH - Gene Frequency
MH - Genetic Association Studies
MH - Genetic Predisposition to Disease
MH - High-Throughput Nucleotide Sequencing
MH - Humans
MH - Lipid Metabolism/*genetics
MH - Logistic Models
MH - Male
MH - Middle Aged
MH - Multiplex Polymerase Chain Reaction
MH - Odds Ratio
MH - Phenotype
MH - *Polymorphism, Single Nucleotide
MH - Risk Factors
PMC - PMC5759188
OTO - NOTNLM
OT - *Case-control study
OT - *Chinese Han population
OT - *Coronary artery disease
OT - *Single nucleotide polymorphisms
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: This study was approved by the
Medical Ethics Committee of Southern Medical University and compliant with
the
principles set forth by the Declaration of Helsinki Principles. Written
informed
consent was provided by all patients. CONSENT FOR PUBLICATION: Not
applicable.
COMPETING INTERESTS: The authors declare that they have no competing
interests.
PUBLISHER’S NOTE: Springer Nature remains neutral with regard to
jurisdictional
claims in published maps and institutional affiliations.
EDAT- 2018/01/10 06:00
MHDA- 2018/07/26 06:00
CRDT- 2018/01/10 06:00
PHST- 2017/02/07 00:00 [received]
PHST- 2017/12/12 00:00 [accepted]
PHST- 2018/01/10 06:00 [entrez]
PHST- 2018/01/10 06:00 [pubmed]
PHST- 2018/07/26 06:00 [medline]
AID - 10.1186/s12872-017-0735-7 [pii]
AID - 735 [pii]
AID - 10.1186/s12872-017-0735-7 [doi]
PST - epublish
SO - BMC Cardiovasc Disord. 2018 Jan 8;18(1):2. doi: 10.1186/s12872-017-0735-7.