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• शक्र
ु शोणितं गर्भभशभयस्तम ् आत्मप्रकृततविकभर
समुर्च्छभ तं गर्भ इतत उ्यते।
Dr.S.Manickam, CHRI 4
Ayurvedic concept of sex
determination
• शक्र
ु स्य बभहुल्यभत ् ऩम
ु भन ् – Presence of Y chromosome – Male
progeny
• रक्तस्य बभहुल्यभत ् स्री – Absence of Y chromosome & Presence of X
chromosome – Female progeny
• सभम्ये क्ऱीब् – Equal dominance of X and Y – Eunuch
• Ex: Klinefelter syndrome (47,XXY) – Male sterile and testicular
atrophy
• Similarly,
• Turner syndrome (45,X) – Female with absence of ovary
• Triple X syndrome (47, XXX)
Dr.S.Manickam, CHRI 5
Modern explanation
• Male genotype – XY
• Female genotype – XX
• In females, one X
chromosome is inactivated
during embryogenesis and
remain as Barr body in the
nucleus.
• By this expression of genes
between different sexes are
equalized - Dosage
compensation
Dr.S.Manickam, CHRI 6
Ayurvedic concept of sex
determination
• Sexual intercourse on 4th, 6th, 8th,10th and 12th day –
Male progeny
• Similarly on odd number days – Female progeny
Dr.S.Manickam, CHRI 7
Length of pregnancy
• Ayurveda – Upto one year
Dr.S.Manickam, CHRI 8
मभसभनम
ु भससक िि
ृ ी
Month Ayurveda Modern
1 कऱऱम ् (Jelly like plate) Embryo has somites and
pharyngeal arches
Second month: Folding of embryo
संघभतो घन:
वऩण्ड् (spherical mass)/
ऩेशी (elongated) /
अर्दुभ म ् (tumor like)
2 Third month: Head size increases
हस्तऩभद सशरसभ Formation of limb buds, face,
ऩंचवऩंडकभ ears, nose and eyes
सूक्ष्म अंगप्रत्यंगविर्भग Nipple and eyelids are formed
सिेन्द्रीयभणि (च) Taste bud appears
Tail disappears
Fourth month: 5½ - 6 weeks – Heart beat can
गर्भहृदय प्रव्यक्ती र्भि be detected
चेतनभधभतु असर्व्यर्चक्त
6 weeks
Dr.S.Manickam, CHRI 9
मभसभनम
ु भससक िि
ृ ी
Month Ayurveda Modern
3 Fourth Face become more human like
month: Swallowing
प्रव्यक्त Primary ossification centres in long and
सिभांगप्रत्यंगवि skull bones
र्भग् Sex can be determined by external
गर्भ् examination (USG)
र्चस्िरत्िमभऩ Intestinal loops are withdrawn into the
द्यते (च) abdominal cavity 11 weeks
Can evoke reflex activity - Muscular
activity
4 Fetus lengthen rapidly
Covered by fine hair – Lanugo hair
Eye brows and head hair – visible
Respiratory movements
Dr.S.Manickam, CHRI 10
मभसभनम
ु भससक िि
ृ ी
M Ayurveda Modern
on
th
5 मन् प्रततबुितरं Movements of fetus can be felt
(mind attains
maturity)
मभंसशोणितोऩचयो
र्ितत (च)
6 बुवि् Skin reddish & wrinkled (Absence
अधधक बऱििोऩचयो of connective tissue)
र्ितत (च) Sucking movements
Born – Difficult to survive
Respiratory and CNS are not
differentiated sufficiently and
Eighth month: less coordination between these
ओज् अर्चस्िरर र्ितत two systems
Dr.S.Manickam, CHRI
6 months 11
मभसभनम
ु भससक िि
ृ ी
Month Ayurveda Modern
7 सिभांग प्रत्यंगविर्भग् Sound can be heard
प्रव्यक्ततर् Eyes sensitive to light
जीिन शर्चक्त् Born – 90% chance of survival
(Garbhopanishad)
8 ओज् अर्चस्िरर र्ितत Well rounded contour –
ओज् सञ्चरि अिस्िभ Subcutaenous fat
(च) 8 months
9 निमदशमैकभदशद्िभदशभ Skin covered by Vernix
नभम अन्द्यतमे जभयते caseosa (products from
sebaceous glands)
Sexual characteristics are
pronounced
Testes descend to scrotum
9 months
Dr.S.Manickam, CHRI 12
Birth defects (or) Congenital malformations
(or) Congenital anomaly
• Teratology
• 3- 8 weeks of development - Vulnerable
• Major organ and organ systems are formed
• Period of organogenesis or embryogenesis
• Most gross structural birth defects are induced
Dr.S.Manickam, CHRI 14
Birth defects - Types
• Malformations – Occurs
during formation process (3-8
weeks)
• Disruption – Alteration of
formed structures by
destructive processes
• Deformations – Mechanical
forces molding a part
• Syndrome – Group of
anomalies having a common
cause
• Association – Nonrandom
appearance of 2 or more
anomalies together. Ex:
VACTERL association
Malformation – Caudal
Dr.S.Manickam, CHRI
dysgenesis 15
Birth defects
Disruption Deformation
Dr.S.Manickam, CHRI 16
Birth Defects
Turner Syndrome Drug induced - Phocomelia
Dr.S.Manickam, CHRI 17
Ayurvedic genetics (अिि
ु ंसशक ससिभन्द्त)
Dr.S.Manickam, CHRI 19
Dr.S.Manickam, CHRI 20