2021 AANS Annual Scientific Meeting Page 1 of 2

ID: 45635 Status: COMPLETE

Author: Karoline Schereck Kreitmeyer

Sao Paulo, Brazil

Email: ksch27@hotmail.com

Abstract Email: ksch27@hotmail.com

Abstract Title: Giant Skull Base Osteoblastoma In A Child: Case Report

Category 1: Pediatric

Category 2: Pediatrics

Abstract: Introduction:
Osteoblastoma is a rare tumor with an incidence of 1% of all tumors, most of them in the axial skeleton. Occurs most
commonly in males (3:1). Rarely it affects the skull, but when it happens, most of them arise from the skull base. There are
less than 40 cases of skull osteoblastoma reported in the literature.
Methods:
Bibliographic review of scientific articles searched in PubMed, Medline, Embase, Science Direct, The Cochrane
Database.
Results:
R.S.J., 6-year-old, male. History of right temporal headache for 15 days followed by epistaxis. The headache
progressively worsened and the patient presented a visual acuity deterioration. No comorbidities and allergies were
reported. Physical examination: GCS 15, areflexic and mydriatic pupils, left sixth cranial nerve palsy, anosmia, bilateral
visual loss, and no motor deficit. Head CT and MRI: expansive lesion in the sella turcica with the invasion of cribriform
plaque, the anterior fossa, sphenoidal and ethmoidal bone and orbits, measuring 5,2x4,9x4,6 cm. An endonasal endoscopic
biopsy was compatible with osteoblastoma. The patient was referred to a neuro-oncology center that started
immunotherapy (Denosumab) treatment, to reduce the size of the lesion. Denosumab therapy (3 cycles) caused the
regression of the tumor, becoming possible an endoscopic endonasal transsphenoidal approach of the lesion. The patient
was submitted to partial resection of the tumor and decompression of the optic nerves. Anatomopathological:
osteoblastoma with areas of fibrous dysplasia. Tumor recurrence occurred in 2 months and the patient was reoperated.
Conclusion:
The standard treatment is complete surgical resection, especially en bloc resection. That can be extremely difficult,
osteoblastoma is a benign vascular bone-forming tumor, therefore it tends to bleed at the surgery. Radiotherapy and
chemotherapy may be alternative treatment options. The rate of recurrence approaches 10%. Herein we report a rare case
of a giant skull base osteoblastoma.
Additional Author(s):
Karoline Schereck Kreitmeyer, Neurosurgeon
Fernando Luis Maeda, Neurosurgeon
Thamara de Almeida Silva Teodoro, Medical Student
Larissa Paixão Batista , Medical Student
Marcelo Senna Xavier de Lima, Neurosurgeon
Laise Leilane Dias Monteiro, Neurosurgery Resident
Marcelo Hamilton Sampaio, Neurosurgeon
Victor Leal de Vasconcelos, Neurosurgeon
Helder Tedeschi, Neurosurgeon

Presentation Preference: Poster Only

Study Design: Case Report

Manuscript: NO

Awards: Young Neurosurgeons Medical Student Abstract Award

2021 AANS Annual Scientific Meeting Page 2 of 2

ID: 45635 Status: COMPLETE

Has the work presented in this abstract or substantially similar work been presented or published previously?

No NA

Has the work in this abstract or substantially similar work being submitted for presentation at another meeting?:

NA

Is your work pending FDA No NA

approval?:

Are you an Advanced Practice Provider and would like your abstract considered for oral presentation in the Advanced Practice Providers
Plenary Session?

Are you a Medical Student or Resident and would like your abstract considered for oral presentation in the Young Neurosurgeons Research
Forum?
No