RESEARCH

Could A Cellular Health

Approach Be The Secret
To Treating Mast Cell
Activation Syndrome?
SUMMARY:
Most people with MCAS have chronic and recurrent
inflammation, with or without allergic symptoms.
This occurs when an aspect of the innate immune
system becomes overactive and releases a flood of
inflammatory chemicals, which may affect every
organ in the body. The symptoms of MCAS will wax
and wane over time.
More and more clinicians are understanding and
diagnosing MCAS on a daily basis - but are many
missing a critical component to long term healing?
MCAS Overview
Mast cells are immune cells that are part of out innate immune
system. They are present in connective tissue throughout the body,
and found in mucosal and epithelial tissue. Mast cells are found in
vascularized tissue except for the central nervous system and the
retina. They are located at the junction point of the host and the
external environment at places of entry of an antigen and in
connective tissue surrounding blood cells, smooth muscle, mucous,
and hair follicles.
When mast cells are functioning optimally, they are known to
regulate vasodilation, vascular homeostasis, innate and adaptive
immune responses, angiogenesis, and detoxification. These cells
originate from the pluripotent progenitor cells of the bone
marrow and mature under the influence of the c-kit ligand and
stem cell tractor in the presence of other distinct grown factors
provided by the microenvironment of the tissue where they are
destined to reside. Under normal conditions, mast cells do not
circulate in the bloodstream but play many roles in the
maintenance of many physiological functions as well as in the
pathophysiology of diseases.
Mast cell activation syndrome (MCAS) was first recognized in the
1980’s, but it’s only been in the last decade that the cases of
mast cell activation syndrome have skyrocketed. It is estimated
that up to 17 percent of the population suffers with this multi
system, multi symptom disease. Perhaps this is unsurprising to
most given the increasingly prevalence of a wide range of allergic
and inflammatory disorders.
Symptoms of MCAS
The full range of patients clinical presentations is extreme, but
symptoms often include
flushing,
Treatment
allergic-type issues,
Once mast cell activation syndrome has been confirmed,
fatigue,
integrative medical treatment typically includes compounded
dermatographism,
mast cell stabilizing medications, mast cell stabilizing
cognitive dysfunction,
nutraceuticals, DAO enzymes, following a whole food, low
irritated eyes/nose/mouth/throat,
glycemic index low histamine diet, and identifying and
adenitis,
removing individual triggers, such as mold exposure, food
dyspnea,
intolerances, nutritional imbalances, toxic exposures, hormonal
palpitations,
imbalances, sleep disturbances, etc.
nausea,
reflux,
abdominal pain,
diarrhea (often alternating with constipation),
Could we be missing a
interstitial cystitis,
vulvovaginitis, foundational
amenorrhagia,
dysmenorrhea, component of
treatment by
fibromyalgia-type pain,
joint hypermobility,
benign growth anomalies (e.g. cysts, fibrosis, vascular
anomalies, poor healing),
headache,
neglecting to address
sensory neuropathy,
dysautonomias (e.g. orthostatic hypotension,
the gut mucosa and
blood pressure and heart rate lability,
thermal dysregulation), cell membrane?
anxiety and mood disorders
an assortment of metabolic/endocrinologic (e.g. thyroid)
aberrancies.
6 THE IMPORTANCE OF OUR GUT IN ADDRESSING PHOSPHOLIPIDS FOR MCAS 7
MCAS TREATMENT TREATMENT

Our gastrointestinal tract harbors the largest population of
mast cells in the body. Mast cells react to both external and
internal stimuli thanks to the variety of receptors they express,
and carry out effector and regulatory tasks by means of the
mediators of different natures they produce. Mast cells are
fundamental elements of the intestinal barrier as they
regulate epithelial function and integrity. Mast calls modulate
both innate and adaptive mucosal immunity, and maintain
neuroimmune interactions, which are key to the functioning
of the gut. Disruption of the intestinal barrier is associated
with an increased passage of luminal antigens into the
mucosa, which facilitate mucosal mast cell activation, and
ultimately, a myriad of disease states.
When we look at the matrix the surrounds mast cells, we see
that phospholipids account for 50 percent of the content of
mast cells. Human mast cells contain a combination of
phosphatidylcholine, phosphatidylethanolamine,
phosphatidylserine, and phosphatidylinositol.
The quantity and ratios of the major phospholipids found within
our body, including the gut mucosa, in addition to balanced
fatty acid remodeling, seem to plan an important role in
controlling inflammation, improving the integrity of the gut
mucosa, and supporting the structure, stability, and integrity of
mast cells.

Gastrointestinal phospholipids play an important role in

Using phospholipid therapy with
mucosal barrier function. It’s estimated that 90 percent of BodyBio PC may be a crucial choice for
the gut mucosa is comprised of phosphatidylcholine. The
health of the intestinal microbiome is linked to a number of
effective therapeutic strategies for the
diseases including, Crohns, Colitis, neurodegenerative treatment of allergic disease.
diseases, cardiovascular disease, and other types of
autoimmune diseases. It’s very clear that the health of our GI
tract is intimately connected to our overall state of health.
Improving the health of our gut mucosa could quite possibly
be one of the most important therapeutic treatment
strategies to help improve mast cell activation
symptomatology.
8 BUTYRATE FOR MCAS
9
Butyrate is another promising and
potential treatment for mast cell
activation syndrome.
Butyrate is a short chain fatty acid that’s produced by the
metabolism of fibre and resistant starch by the intestinal
organisms. Butyrate regulates the intestinal mucosal immune
response by regulating the functions of the intestinal mucosa
immune and non immune cells. Butyrate also influences the
differentiation, recruitment and apoptosis of cells. Use code
Butyrate has been known to have many gut, neurological, and MCAS20 for 20% off your first
anti-inflammatory benefits but when it applies to mast cell
order of BodyBio products
activation syndrome, the data proves that butyrate might be one
of your best mast cell stabilizing tools. Supplementation with
sodium butyrate has been shown to inhibit allergen induced
histamine release and shown to modulate the function of our
innate immune system. Butyrate also inhibits mast cell
degranulation while enhancing inflammatory mediator
production.
 RESOURCES RESOURCES
10
https://www.frontiersin.org/articles/10.3389/fimmu.2015.0
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butyrate-enhances-intestinal-integrity%2C-mast-Wang-
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