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Surfactant (Physiology) 2
Surfactant (Physiology) 2
➢ Overview of Surfactant
➢ Definition and source of secretion
➢ Structure and Composition
➢ Formation of Surfactant
➢ Requirement for its synthesis
➢ Functions
➢ Clinical correlation
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➢ Pulmonary Surfactant Structure and Its Composition ➢ Pulmonary Surfactant Structure and Composition
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➢ Pulmonary Surfactant Structure and Its Composition ➢ Regulation of Synthesis and Secretion
1. Lipids: 90%
•Dipalmitoylphosphatidylcholine (62%)
•Phosphatidylglycerol (5%)
•Other phospholipids (10%)
•Neutral lipids (13%)
2. Proteins: 8%
•Albumin
•Immunoglobulin A (IgA)
•Apoproteins (SP-A, -B, -C, - D)
3. Carbohydrates: 2%
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A. Hormonal factors
● Surfactant synthesis is regulated by hormones,
● Concentration of protein in the surfactant, 1. Glucocorticoid hormones: Cortisol stimulates surfactant synthesis.
Secretion of glucocorticoids increases
● Stretching of lung and toward term. Number of glucocorticoid receptors in
● Various pharmacological agents. lungs also increases in third trimester of pregnancy.
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➢ Synthesis and Secretion ➢ Functions of Surfactant
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➢ Mechanism of Surfactant ➢ Mechanism of Surfactant
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➢ Clinical correlation ➢ Clinical correlation
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➢ Clinical correlation
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