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https://doi.org/10.1007/s00383-020-04808-8
ORIGINAL ARTICLE
Abstract
Purpose We sought to estimate the prevalence, incidence, and timing of surgery for elective and non-elective hernia repairs.
Methods We performed a retrospective cohort study, abstracting data on children < 18 years from the 2005–2014 DoD Mili-
tary Health System Data Repository, which includes > 3 million dependents of U.S. Armed Services members. Our primary
outcome was initial hernia repair (inguinal, umbilical, ventral, or femoral), stratified by elective versus non-elective repair
and by age. We calculated prevalence, incidence rate, and time from diagnosis to repair.
Results 19,398 children underwent hernia repair (12,220 inguinal, 5761 umbilical, 1373 ventral, 44 femoral). Prevalence
of non-elective repairs ranged from 6% (umbilical) to 22% (ventral). Incidence rates of elective repairs ranged from 0.03
[95% CI: 0.02–0.04] (femoral) to 8.92 [95% CI: 8.76–9.09] (inguinal) per 10,000 person-years, while incidence rates of
non-elective repairs ranged from 0.005 [95% CI: 0.002–0.01] (femoral) to 0.68 [95% CI: 0.64–0.73] (inguinal) per 10,000
person-years. Inguinal (median = 20, interquartile range [IQR] = 0–46 days), ventral (median = 23, IQR = 5–62 days), and
femoral hernias (median = 0, IQR = 0–12 days) were repaired more promptly and with less variation than umbilical hernias
(median = 66, IQR = 23–422 days).
Conclusions These data describe the burden of hernia repair in the U.S. The large variation in time between diagnosis and
repair by hernia type identifies an important area of research to understand mechanisms underlying such heterogeneity and
determine the ideal timing for repair.
Level of evidence Prognosis study II.
Keywords Umbilical hernia · Inguinal hernia · Ventral hernia · Femoral hernia · Pediatric hernia
4
* Kristin A. Sonderman Department of Surgery, Boston Children’s Hospital, Boston,
kristin.sonderman@umm.edu MA, USA
5
1 Uniformed Services University of the Health Sciences,
Center for Surgery and Public Health, Brigham
Bethesda, MD, USA
and Women’s Hospital, Harvard Medical School, Boston,
6
MA, USA Orthopaedic and Arthritis Center for Outcomes Research
2 and Policy, Department of Orthopedic Surgery, Brigham
Harvard T.H. Chan School of Public Health, Boston, MA,
and Women’s Hospital, Innovation Evaluation in Orthopedic
USA
Treatments Research Center, Harvard Medical School,
3
Division of Trauma, Burns, and Surgical Critical Care, Boston, MA, USA
Department of Surgery, Brigham and Women’s Hospital, 7
22 S. Greene St., Baltimore, MD 21201, USA
Boston, MA, USA
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588 Pediatric Surgery International (2021) 37:587–595
appropriate timing for umbilical hernia repairs with attention Classification of Diseases, 9th Revision, Clinical Modifi-
to the possibility of spontaneous closure. cation (ICD-9CM) diagnosis code and either an ICD-9CM
Information from epidemiological studies adds to our procedure code or Current Procedural Terminology (CPT)
understanding of these conditions and may also be useful to code consistent with the given type of hernia repair [14]. The
inform debates on best clinical practice. Large cohort stud- coding classification is shown in the Appendix. We stratified
ies from Taiwan have reported cumulative incidence esti- each type of hernia repair by those performed electively and
mates for pediatric inguinal hernias, with 4.2% of children those performed urgently or semi-electively. We grouped
undergoing inguinal hernia repair from birth to age 6 [6, 7]. urgent and semi-elective repairs together as “non-elective”
However, large-scale studies are lacking in the literature for repairs. “Non-elective” repairs were defined as those with
umbilical, ventral, and femoral hernias. Furthermore, there either: (1) an ICD-9CM diagnosis code indicating gangrene
are no published reports of large-scale U.S.-based estimates or incarceration and any repair within 1 week or (2) a CPT
of incidence or timing of repair. We sought to estimate the code indicating repair of an incarcerated or strangulated her-
prevalence, incidence, and timing of surgery for elective and nia. Within the population of non-elective repairs, we looked
non-elective hernia repairs from a large, national administra- at the distribution of time to surgery. We did not include
tive dataset of children in the U.S. diagnosis codes for incisional hernias or recurrent hernias.
Patient characteristics
Material and methods
We collected demographic characteristics for all children
Study design and data source
undergoing repair, including age, sex, race/ethnicity, pre-
term (defined by ICD-9 codes), and environment of care
We performed a retrospective cohort study, abstracting
(“direct” care at a military hospital versus “purchased” care
data from the Department of Defense Military Health Sys-
at a civilian hospital). We additionally described clinical
tem Data Repository (MDR) over a 10-year period from
characteristics, including type of repair (laparoscopic ver-
October 1, 2005 to September 30, 2014. The MDR tracks
sus open), urgency of repair (elective versus non-elective,
healthcare delivered to a universally insured population of
as described above), and specialty of the operating surgeon
active, reserve, and retired members of the United States
(general surgeon, pediatric surgeon, urologist/pediatric
Armed Services and their dependents. These data repre-
urologist, or others). A previously published and validated
sent > 9 million military personnel and their dependents,
pediatric surgical risk score for mortality was calculated at
including > 3 million children, and have been shown to be
the time of repair, based on other diagnoses recorded during
a good representation of the national U.S. population [8].
the same hospitalization, as a summary measure of patient
The data are longitudinal in nature, and include all medical
comorbidity [15].
care received while enrolled in the Department of Defense’s
TRICARE health insurance program, including outpatient
visits, hospitalizations, surgical procedures, imaging, and Statistical analysis
medications. Additional details of the database have been
previously described [9–12]. The database has been exter- We presented the distribution of surgical repair for each type
nally validated by comparing the MDR to the previously of hernia. We calculated overall and age-stratified incidence
validated American College of Surgeons National Surgical rates. We considered the following age groups at the time of
Quality Improvement Program- Pediatric (NSQIP-P), which diagnosis: < 2 years, 2–3 years, 4–5 years, 6–8 years, 9–12
showed that patients included in the MDR were comparable years, and 13–17 years. We next calculated separate statistics
to those included in NSQIP-P, and that the MDR is espe- for elective and non-elective repairs. To calculate relevant
cially valuable as a clinical outcomes research resource [13]. follow-up time, we included periods of continuous enroll-
ment for all children enrolled in TRICARE. For incidence
Study population and classification of outcomes rate estimation, participants accumulated person-time at risk
for each endpoint until hernia repair, the end of enrollment
We included all children who underwent initial hernia repair in the TRICARE health insurance program, or the age of 18
prior to age 18 years of one of the following four hernia years. Incidence rates were calculated as number of events
types: umbilical, inguinal (including unilateral and bilat- over total person-time at risk for the overall rates and over
eral), ventral, and femoral hernia. Ventral hernias included the relevant person-time at risk for the rates stratified by
those classified as epigastric, Spigelian, “other ventral her- age and urgency of repair. We constructed exact confidence
nia,” and “other hernia of the anterior abdominal wall.” A intervals for incidence rates under the assumption that the
hernia repair of each type was defined by ≥ 1 International observed event-rates followed the Poisson distribution.
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Pediatric Surgery International (2021) 37:587–595 589
For each hernia type, we calculated the median time to were completed within 48 h of diagnosis. Combining all
elective repair from the date of diagnosis across patients who hernias, repairs were most frequently performed by a gen-
underwent each type of hernia repair. For the subgroup of eral surgeon (22%), followed by a pediatric surgeon (18%).
children who had a non-urgent diagnosis recorded in their Nineteen percent of inguinal hernia repairs were performed
medical record and subsequently required a non-elective by a urologist or pediatric urologist. Children were more
repair, we calculated the median time to non-elective repair frequently referred to as a “purchased care” setting for all
from the first recorded date of diagnosis, a measure of time hernia types (Table 1).
between initial hernia diagnosis and presentation with an
incarcerated hernia. We performed all statistical analyses Distribution of hernia repair by type
using SAS 9.4 (Cary, NC) and R 3.5.2. The Partners Human
Research Committee approved this research. The greatest proportion of elective inguinal hernia repairs
(37%) and the majority of non-elective inguinal her-
nia repairs (54%) occurred before the age of 2 years. The
Results occurrence of both elective and non-elective inguinal hernia
repairs decreased with increasing age. Elective umbilical
Patient characteristics hernia repairs were most commonly performed in children
aged 4–5 years (29%). Non-elective umbilical repairs were
There were 3,033,305 children enrolled in the MDR over most common in children < 2 years, with 43% of all non-
2005–2014. We identified 19,398 children who underwent elective repairs recorded in children < 4 years. Similar to
hernia repair. Of these, 12,220 (63%) were inguinal, 5761 inguinal hernia repairs, elective ventral hernia repairs were
(30%) were umbilical, 1373 (7%) were ventral, and 44 most common in the first 3 years of life; however, non-
(< 1%) were femoral (Fig. 1). Characteristics of the children elective ventral hernia repairs were distributed more evenly
undergoing repair are shown in Table 1. The distribution of across all age groups. Both elective and non-elective repairs
hernia repairs among males versus females was similar for for femoral hernia were seen more frequently among older
umbilical, ventral, and femoral hernias. However, a predomi- children (Table 2).
nance of inguinal hernia repairs occurred in males. Umbili-
cal hernia repairs were relatively more common among Incidence rates
black children, while femoral hernia repairs were relatively
more common among white children. Median follow-up time of children in the MDR was
Most (96%) children had a pediatric surgical risk score 6.1 years (IQR: 3.4–9.0).Overall incidence of elective
of 0, indicating extremely low risk of peri-operative mortal- hernia repair per 10,000 person-years was 8.92 [95% CI:
ity at the time of hernia repair. For hernia types other than 8.76–9.09] for inguinal, 4.24 [95% CI: 4.13–4.36] for
inguinal, 99% were performed by open technique. Inguinal umbilical, 0.85 [95% CI: 0.80–0.90] for ventral, and 0.03
hernias were repaired laparoscopically 5% of the time. Non- [95% CI: 0.02- 0.04] for femoral hernias. Overall incidence
elective repairs were performed for 22% of ventral hernias, of non-elective hernia repair per 10,000 person-years was
16% of femoral hernias, 7% of inguinal hernias, and 6% of 0.68 [95% CI: 0.64–0.73] for inguinal, 0.27 [95% CI:
umbilical hernias. Most cases defined as non-elective (95%) 0.24–0.30] for umbilical, 0.23 [95% CI: 0.21–0.26] for
Children Enrolled in
TRICARE Insurance
2005-2014
n=3,033,305
Inguinal Hernia Repair Umbilical Hernia Repair Ventral Hernia Repair Femoral Hernia Repair
n= 12,220 n= 5761 n= 1373 n= 44
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590 Pediatric Surgery International (2021) 37:587–595
ventral, and 0.005 [95% CI: 0.002–0.011] for femoral of non-elective inguinal hernia repair per 10,000 person-
hernias. When stratified by age group, incidence gener- years ranged from 3.9 [95% CI: 3.6–4.2] in children < 2
ally decreased with increasing age (Fig. 2). This was most years to 0.15 [95% CI: 0.11–0.21] in children 9–12 years.
pronounced for inguinal hernias, where the incidence of Incidence of ventral hernia repair also decreased with
elective hernia repair per 10,000 person-years ranged from increasing age, with incidence of elective ventral hernia
38.3 [95% CI: 37.4–39.3] in children < 2 years to 2.8 [95% repair per 10,000 person-years ranging from 3.6 [95% CI:
CI: 2.6–3.0] in children 9–12 years, while the incidence 3.3–3.9] in children < 2 years to 0.26 [95% CI: 0.21–0.33]
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Pediatric Surgery International (2021) 37:587–595 591
Inguinal
Overall 12,220 (63) 11,348 (93) 872 (7)
Age at repair (years)
0–1 4704 (38) 4232 (37) 472 (54)
2–3 2129 (17) 2014 (18) 115 (13)
4–5 1498 (12) 1423 (13) 75 (9)
6–8 1422 (12) 1365 (12) 57 (7)
9–12 1043 (9) 980 (9) 63 (7)
13–17 1424 (12) 1334 (12) 90 (10)
Umbilical
Overall 5761 (30) 5417 (94) 344 (6)
Age at repair (years)
0–1 1042 (18) 964 (18) 78 (23)
2–3 1264 (22) 1195 (22) 69 (20)
4–5 1609 (28) 1555 (29) 54 (16)
6–8 992 (17) 937 (17) 55 (16)
9–12 460 (8) 423 (8) 37 (11)
13–17 394 (7) 343 (6) 51 (15)
Ventral
Overall 1373 (7) 1077 (78) 296 (22)
Age at repair (years)
Fig. 2 Incidence of each hernia type stratified by age group
0–1 359 (26) 303 (28) 56 (19)
2–3 306 (22) 240 (22) 66 (22)
4–5 206 (15) 166 (15) 40 (14)
[95% CI: 0.06–0.13] in children 9–12 years. Incidence of
6–8 172 (13) 128 (12) 44 (15)
femoral hernias was so low that no clear trends by age
9–12 129 (9) 97 (9) 32 (11)
13–17 201 (15) 143 (13) 58 (20)
were apparent.
Femoral
Overall 44 (0.2) 37 (84) 7 (16)
Timing of hernia repairs
Age at repair (years)
0–1 4 (9) 4 (11) 0 (0)
The time between first diagnosis and elective hernia repair
2–3 5 (11) 4 (11) 1 (14)
varied substantially by type of hernia and age at diagno-
4–5 7 (16) 6 (16) 1 (14)
sis. Median time from first diagnosis to elective repair was
6–8 14 (32) 12 (32) 2 (29)
20 days (IQR: 0–46) for inguinal hernia, 66 days (IQR:
9–12 4 (9) 3 (8) 1 (14)
23–422) for umbilical hernia, 23 days (IQR: 5–62) for ven-
13–17 10 (23) 8 (22) 2 (29)
tral hernia, and 0 days (IQR: 0–12) for femoral hernia. For
elective umbilical hernia repair, there was pronounced varia-
tion in time to surgery by age at diagnosis, with median time
to repair of 425 days (46–1159) in children < 2 years ranging
in children 9–12 years and incidence of non-elective ven- to median time to repair of 25 days (1–61) in children 13–17
tral hernia repair per 10,000 person-years ranging from years. No clear trends by age were observed for the other
0.76 [95% CI: 0.63–0.91] in children < 2 years to 0.09 hernia types (Table 3).
[95% CI: 0.06–0.13] in children 9–12 years. The incidence Of children who underwent a non-elective hernia repair,
of elective umbilical hernias per 10,000 person-years was many had a prior non-urgent hernia diagnosis recorded
17.6 [95% CI: 17.0–18.3] in children aged < 2 years to in their medical record, with 43% of non-elective ingui-
0.73 [95% CI: 0.64–0.83] in children 13–17 years. The nal repairs, 64% of non-elective umbilical hernia repairs,
incidence of non-elective umbilical hernia repairs per and 68% of non-elective ventral hernia repairs previously
10,000 person-years decreased with increasing age from diagnosed. Of the 7 who underwent non-elective femoral
1.15 [95% CI: 0.98–1.33] in children < 2 years to 0.09 hernia repair, 5 were diagnosed and underwent repair the
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592 Pediatric Surgery International (2021) 37:587–595
same day. Like the trend seen with elective repairs, median Inguinal hernia repairs were the most common, compris-
time to non-elective repair was longer for umbilical her- ing 63% of all repairs, followed by umbilical (30%), ventral
nias (67, IQR 25–412 days) compared to inguinal (21, IQR (7%), and femoral (< 1%) repairs. The prevalence of non-
6–54 days), ventral (36, IQR 18–76 days), and femoral (16, elective repairs ranged from 6% of all repairs for umbilical
IQR 15–16 days) hernias. Seventy-three children < 2 years hernias to 22% of all repairs for ventral hernias. Incidence of
and 31 children aged 2–3 years with a previously diagnosed elective hernia repairs per 10,000 person-years ranged from
umbilical hernia required a non-elective repair; median time 8.9 for inguinal repairs to 0.03 for femoral repairs, while the
to repair was 318 days (IQR: 39–696) in the children < 2 incidence of non-elective repairs per 10,000 person-years
years and 67 days (IQR: 34–560) in the children aged 2–3 ranged from 0.68 for inguinal repairs to 0.005 for femo-
years. While median time to non-elective repair was longer ral repairs, with incidence rates generally decreasing with
than median time to elective repair for ventral hernias, increasing age. Inguinal and ventral hernias were typically
this time was shorter for inguinal and umbilical hernias repaired electively soon after diagnosis. There was, however,
(Table 4). substantial variation in the time from diagnosis to elective
repair of umbilical hernias.
These findings are consistent with and expand upon those
Discussion from prior reports. Of all hernia types, pediatric inguinal
hernias have been best described. Two retrospective, longi-
We analyzed a large, national database, including > 3 million tudinal studies from the Taiwanese national health insurance
children in our cohort. Of these, we identified > 19,000 chil- database reported a cumulative incidence of 6.6% in males
dren who underwent a hernia repair between 2005 and 2014. and 0.74% in females by age 15 years, with 63% of children
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Pediatric Surgery International (2021) 37:587–595 593
undergoing repair < 4 years [6, 7]. A large, cross-sectional population, with current rates of laparoscopy use expected
study on inguinal hernia repairs at U.S. academic medical to be higher than those demonstrated by these data.
centers included > 26,000 initial inguinal hernia repairs, Timing of hernia repair has been previously studied in
with 76% of children undergoing repair < 4 years [16]. These the case of inguinal hernias. The Taiwanese national health
compare to 67% of children undergoing repair < 4 years in insurance database studies on pediatric inguinal hernia
the current study. In addition, two large, single-institution, reported a mean time from first diagnosis to surgery of
retrospective analyses have described children undergoing 59 days, which did not differ between elective and urgent
inguinal hernia repair, with mean age at diagnosis reported repairs [6]. Similarly, in the current work, the time from
to be 2.7–3.3 years [17, 18]. Incarceration has been reported diagnosis to surgery was similar between children under-
in 4–12% of pediatric inguinal hernia presentations, which going elective and non-elective inguinal hernia repairs—
may increase to 30% in infants [2, 6, 16, 18, 19]. In our there did not appear to be a substantial delay to explain the
study, 7% of inguinal hernias were repaired non-electively non-elective presentations. In contrast, a retrospective study
for incarceration, with over half of these non-elective opera- using administrative data from Canada on children < 2 years
tions occurring in children < 2 years. found a median time to surgery of 35 days, with an increased
The largest published study on umbilical hernia repairs risk of incarceration observed with wait times > 14 days
followed 377 children treated at 3 U.S. teaching hospitals [19].
from 1964 to 1974, with 61% of repairs occurring < 4 years This study is susceptible to the limitations of administra-
and 7% occurring urgently [20]. A second long-term ret- tive data, including the lack of clinical variables such as
rospective review also reported a 7% prevalence of incar- specific neonatal age in days or weight at the time of surgery
ceration [21]. In the current study, we found a prevalence [27]. In the MDR, specific procedure dates are unavailable
of non-elective umbilical hernia repair of 6%. It is standard for procedures performed in the inpatient setting; instead,
practice to observe asymptomatic umbilical hernias until the the first date of the admission was applied as the proce-
age of 4 years, given that many will close spontaneously, dure date. We were unable to reliably capture any history
obviating the need for surgery [22]. Umbilical hernia repair of hernia repair that may have occurred outside the MDR,
occurred most commonly at age 4–5 years in the current during any period when a child was not covered in the TRI-
study; however, 43% of all non-elective umbilical hernia CARE program. These children would have contributed
repairs occurred in children < 4 years. follow-up time to the denominator without truly being at
There are few published reports on ventral or epigastric risk for the event of interest; therefore, the incidence rates
hernias in children. One single-institution, retrospective presented may underestimate the incidence of abdominal
review over 14 years described 38 epigastric hernia repairs wall hernia repairs. The classification of elective versus non-
in children < 18 years, with mean age at presentation of 4.3 elective repairs was made on the basis of CPT and ICD-9
years. Of these, 7 presented with an asymptomatic, nonre- codes; there is the potential that a hernia found to be stuck
ducible epigastric mass, and 6 presented with a tender epi- at the time of an elective repair was therefore classified as a
gastric mass [23]. Taken together, this prevalence of 34% non-elective repair. As most repairs of incarcerated hernias
is similar to the prevalence of incarceration observed in the were performed within 48 h of diagnosis, we were unable to
current study. The group of ventral hernias includes more investigate outcomes of children undergoing delayed repair
heterogeneity than the other groups of hernias in this study. after an incarceration event, which may be a topic for future
It is important to note that epigastric hernias are most likely study. This study uses data through 2014, which were the
to contain preperitoneal fat, rather than intraperitoneal con- most recent data available during the study period. Despite
tents, making incarceration much less clinically relevant for this, our study covered a 10-year period, which provided us
this hernia type. The group of ventral hernias also includes with valuable information about the prevalence, incidence,
incisional hernias, which are at risk of presenting with bowel and timing of surgery for elective and non-elective hernia
incarceration and obstruction. We found femoral hernias to repairs in children in MHS.
be exceedingly rare in children, comprising approximately Despite these limitations, there are several advantages to
0.2% of all groin hernias in our cohort. Other reports in the the MDR, including availability of inpatient and outpatient
literature have found femoral hernias account for 0.4–2.8% information (both diagnoses and procedures), its national
of all groin hernias [24–26]. The overall low proportion of scope, and its longitudinal nature over an extended period
laparoscopic cases may be related to a temporal effect. While of time. MDR has been compared to the validated National
there are no reports on the prevalence of laparoscopic hernia Surgical Quality Improvement Program-Pediatric database
repairs in the pediatric literature, a study of inguinal hernia and was found to be comparable in regard to demographics
repairs in adults showed an increase in the use of laparos- and clinical outcomes, with the added advantage of offering
copy over time, ranging from 27% of cases in 2008 to 40% longer follow-up beyond the 30 day peri-operative period
in 2014 [19]. This same trend may present in the pediatric [13].
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