SPUTNIK-V

The dosing for the Sputnik V Vaccine is scheduled

for two doses.
After the first dose, the second dose must be

VACCINE
given after 21 days or 3 weeks. The first dose
contains 0.5 mL rAD26 (recombinant adenovirus
serotype 26 particles), while the second dose
contains 0.5 mL rAD5 (reconbinant adenovirus
serotype 5 particles).

Gan, A., Gotil, I., Hernandez, J., Jangao, J.

MECHANISM OF ACTION
HISTORY
Sputnik-V vaccine utilizes safe and effective adenovirus
Sputnik V is named after the first Soviet space vectors; Adenovirus 26 (Ad26) and Adenovirus 5 (Ad5),
satellite, Sputnik-1, which was launched in 1957 and is to mimic the spike feature of the SARS-COV-2 protein
also the first satellite to be placed in orbit. Just like gene. The difference of the vectors contributes to the
longer-lasting immunity against the virus.
the satellite, the vaccine is the first vaccine to be
registered in the world. The Sputnik V team is headed
by Alexander Ginstburg along with 17 other CREATION OF THE VECTOR
professionals.
TIMELINE spike from the "crown" of
SARS-COV-2

Pre-clinical trials - performed on animals,

including 2 primates.
August 1, 2020 - Phase 1 and 2 completion,
volunteers did not present unwanted side
effects, none of the participants were infected
after the administration of the vaccine. In each adenovirus
August 11, 2020 - registered as a COVID-19 vector, a gene encoding
vaccine by the Russia Ministry of Health. S protein, taken from
the "crown" feature of
August 25, 2020 - Launch of post-registration the SARS-COV-2's
clinical trials with 31,000 individuals in Russia and spikes is introduced.
Adenovirus Adenovirus
Vector 26 Vector 5
Belarus. People from UAE, India and Venezuela (1st Dose) (2nd Dose)
also participated in the clinical trials.
February 3, 2021 - Phase 3 clinical trial result
publication. The vaccine showed strong efficacy 1ST As the vector enters the
O S E cell, the S protein is
at 91.6% based on the analysis of data on 19,866 D synthesized, producing
volunteers. It also showed high levels of antibodies. In response,
immunity begins.
immunogenicity and safety among people,
including the elderly group.

MANUFACTURER gene coding

S protein
AD26
The Sputnik V or Gam-COVID-Vac is manufactured by
the Gamaleya National Center of Epidemiology and
Microbiology in Moscow, Russia.
ANTIBODIES
It is the world’s leading research institution which was
founded in 1891. In 1949, they named the center after
Nikolai Gamaleya, a pioneer in Russian microbiology CELL
2ND
studies. Since 1997, the director of the center has been DOS
Alexander Ginstburg, who is a member of the Russian E
Academy of Sciences. They have developed and After 21 days, the cycle
is repeated, using
registered vaccines for ebola fever in 2015 and 2020. another unknown
On the other hand, their influenza and MERS vaccines vector (AD5), which
attributes to the
are currently ongoing advanced stages of clinical boosted immune
trials. Adding to the list is Sputnik V, the first response and longer
registered COVID-19 vaccine in the world. immunity from the
virus.
gene coding

ADVERSE REACTIONS S protein

AD5

Out of 16,427 individuals who got the vaccination, 45

experienced significant adverse effects, including
deep vein thrombosis, hemorrhagic stroke, and
hypertension, according to studies. The independent ANTIBODIES
data monitoring committee, however, has reportedly CELL
determined that none of these were thought to be
connected to the vaccination, according to the
research.
Common Side Effects: Pain, redness, or swelling at the
site of injection, Asthenia (lack of energy / abnormal
physical weakness), Fatigue (feeling tired), Body and
muscle pain, Cough and Sore throat, Runny nose, Fever
and Chills, Nausea and Vomiting, Diarrhea and
Headache

About Us. Sputnik V - the first registered vaccine against COVID-19. Official website vaccine against coronavirus Sputnik V. (n.d.). Retrieved September 25, 2022, from
https://sputnikvaccine.com/about-us/
Jeong, M. (2021, May 10). What are the side effects of the Sputnik V COVID-19 vaccine? Www.medicalnewstoday.com. https://www.medicalnewstoday.com/articles/sputnik-v-covid-19-vaccine-how-
much-do-we-know-about-its-side-effects