Bioabsorbable self-folding tools for single cell capture and manipulation Inventors:

Case ID: Category(s):

C12843 Technology Classifications >
Disclosure Date: Medical Devices > Surgical,
Technology Classifications >
12/24/2013
Medical Devices,
Biocompatible Micro – Grippers for Single Cell Analysis
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Invention Novelty: Biocompatible, self- folding micro- grippers able to capture and manipulate a single cell activated by desired environmental
stimulus for both in vivo and in vitro analysis For Information, Contact:
Heather Curran
hpretty2@jhu.edu
Value Proposition: Scientists and engineers are consistently seeking improved tools for exploring the behavior of individual cells, but current 410-614-0300
biopsy tools collect samples too large and heterogeneous (mixed) misrepresenting the unique nature of a single cell. This technology is a
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completely tetherless, biocompatible micro-gripper able to capture a single cell activated by environmental stimuli, increasing precision and
facilitating in vivo and in vitro analysis. Other advantages include: Bookmark this page
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· Grippers trap whole cell, ideal for image analysis or targeted drug administration

· Customizable gripper model and surface patterns for varying cell type/ size

· Possible development of specialized high-throughput assays

· Biodegradable over-time for safe in vivo analysis

Technical Details: Johns Hopkins researchers have developed a tetherless, biocompatible micro-scale grippers for single cell capture and micro-
environment analysis; offering its diverse applications for high-throughput assay development, targeted surgical biopsy sampling, to drug delivery.
Its unique silicon composite and gripper design provide high tensile strengths while preserving whole -cell integrity when in contact and allows cell
to remain exposed varying to biochemical, or physiological conditions. Grippers are customizable in fold-angle, tip thickness for specific cell types,
and are passively activate via changes in temperature, or chemical environment.

Looking for Partners: To develop and commercialize the technology as a novel single cell analysis tool for in vitro and in vivo cell applications

Stage of Development: Prototype

Data Availability: Under CDA/NDA

Patent Status: Pending

Publication(s)/Associated Cases: Angew.Chem.2014,126,1-6, Advanced Materials, 2013; 25 (4): 514, Gastroenterology, 2013; 144 (4):691,

Patent Information:
Serial Patent Issued Expire Patent
Title App Type Country File Date
No. No. Date Date Status
BIORESORBABLE SELF-FOLDING TOOLS FOR SURGERY, SINGLE CELL CAPTURE AND ORD: Ordinary United
14/885,598 11,331,085 10/16/2015 5/17/2022 2/11/2037 Granted
MANIPULATION Utility States
BIORESORBABLE SELF-FOLDING TOOLS FOR SURGERY, SINGLE CELL CAPTURE AND CON: United
17/745,044 5/16/2022 Pending
MANIPULATION Continuation States

Direct Link:
https://jhu.technologypublisher.com/technology/24319

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