DRUGS MECHANISM OF INDICATION CONTRAINDICATION SIDE EFFECTS NURSING

ACTION RESPONSIBILITIES
Generic Name: Antitumor  Therapeutic Pregnancy D, CNS: Arthralgia,  Assessment
topotecan (Rx) product with  outcome: breastfeeding, asthenia, • Monitor liver
topoisomerase I– Decreased  hypersensitivity, severe headache, myalgia, function tests: AST, ALT,
Brand Name: tumor  bone marrow pain, weakness alkaline
inhibitory activity; 
Hycamtin Size. depression phosphatase, which
topoisomerase  I GI: Abdominal may be elevated;
Classification: relieves torsional USES: Metastatic  pain, constipation, creatinine,
Avastin is classified strain in DNA by ovarian cancer  diarrhea, BUN
as a "monoclonal causing single-strand after failure of  obstruction, • Assess buccal cavity
antibody" and breaks; causes double- traditional  nausea, stomatitis, for dryness, sores or
"anti- strand DNA damage chemotherapy,  vomiting, ulceration, white
angiogenesis" drug relapsed small  increased ALT, AST, patches, oral pain,
cell lung cancer, anorexia bleeding,
Dosage and routes: cervical cancer dysphagia
Adult: HEMA:
- 0.75 mg/m² by Neutropenia, Patient/family
intravenous leukopenia, education
infusion over 30 thrombocytopenia, • Advise patient to
minutes daily on anemia, sepsis avoid foods with citric
Days 1, 2, and 3, in acid
combination with INTEG: Total or hot flavor or rough
cisplatin 50 mg/m² alopecia texture if stomatitis is
on Day 1, of a 21- present; to drink
day cycle. RESP: Dyspnea,  adequate fluids
cough, interstitial • Advise patient that
lung total alopecia may
disease occur;
hair grows back but may
be different in color
and texture
• Advise patient to
report stomatitis; any
bleeding, white spots,
ulcerations in mouth;
tell patient to examine
mouth daily; report
symptoms