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  • Limbs Development

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    Mohamed Farahat
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    1) Between 5-7 weeks, limb buds appear covered by ectoderm and mesoderm, with bones and digital rays forming by week 6 as mesoderm condenses. 2) By week 7, mesoderm separates into flexor and extensor muscle compartments in the limbs. 3) Later, limb buds undergo rotation and adduction that differs between upper and lower limbs, forming preaxial and postaxial borders and ventral/dorsal surfaces.

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    LIMBS DEVELOPMENT

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    1) Between 5-7 weeks, limb buds appear covered by ectoderm and mesoderm, with bones and digital rays forming by week 6 as mesoderm condenses. 2) By week 7, mesoderm separates into flexor and extensor muscle compartments in the limbs. 3) Later, limb buds undergo rotation and adduction that differs between upper and lower limbs, forming preaxial and postaxial borders and ventral/dorsal surfaces.

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    5 views8 pages

    Limbs Development

    Uploaded by

    Mohamed Farahat
    1) Between 5-7 weeks, limb buds appear covered by ectoderm and mesoderm, with bones and digital rays forming by week 6 as mesoderm condenses. 2) By week 7, mesoderm separates into flexor and extensor muscle compartments in the limbs. 3) Later, limb buds undergo rotation and adduction that differs between upper and lower limbs, forming preaxial and postaxial borders and ventral/dorsal surfaces.

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    © All Rights Reserved
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    of 8

    Limbs development

    Dr / Mubarak Hemdan
    5th week 6th week
    • Limb bud appeared and ➔Bones of each limb appears as a
    covered by mesodermal condensation which
    ➔Outer ectodermal covering undergo chondrification
    →skin followed by ossification
    ➔Inner mesodermal core from → ➔Mesodermal condensation in
    lateral plate mesoderm, Some hand and foot results in appear
    migrating myotomes sharing in of digital rays
    formation in girdle muscles
    7th week 8th week

    • Mesoderm forms muscle mass which ➔ The borders


    separates into flexor and extensor • Pre axial cephalic border near
    compartments the big digit
    • Post axial caudal border
    ➔ The surfaces
    • Ventral surface→flexor
    • Dorsal surface → extensor

    • At a later stage the limb buds undergo


    rotation and adduction, rotation differs
    between the upper and lower limb buds
    (90 degree laterally, 90 degree medially)
    ❖ Congenital anomalis
    1. Amelia ➔ complete absences of one or more limb
    2. Meromelia ➔ the limbs are represented only by hand or foot
    3. Syndactyly ➔ fused one or more digits
    4. Polydactyly ➔ supernumerary digits
    5. Cleft hand or foot (Lobster Claw deformity)➔ one or more middle digits are absent, thus the hand or foot divided into
    two parts in each part digits are fused

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