FR-i3L-AA-2021-01-Rev.

Indonesia International Institute for Life Science

School of Life Sciences
Bioinformatics
[BI2102]
POPULATION GENETICS

Semester 3
Type of Course : Common course
Prerequisites :-
Head of Department : David Agustriawan., Ph.D.
Course Coordinator : Rizky Nurdiansyah, S.Si., M.Si.
Credit Unit : 3 CUs

Total Course Assessments

Type Weight
Assignments 25%
Mid Term Exam 35%
Final Exam 40%

Attendance Policy
Students must follow i3L code of conduct.
● Students are expected to follow the entire course (100% attendance), however, to be eligible for
the examination, a minimum of 80% attendance is acceptable.
● Absences are not judged, and there is no such thing as an “excused absence” at i3L. Students are
either able to attend or not.
● An absence is excused only if the student is under a doctor’s care. In this case Medical
Certificate must be submitted to Academic Operations and notification by email to Academic
Operations and Faculty is a matter of courtesy to faculty and staff.

Grading Policy
Grades for this course will be determined as follow:
Score Range Grade Stat
us
85 – 100 A Passe
d
80 – 84.9 A- Passe
d
75 – 79.9 B+ Passe
d
70 – 74.9 B Passe
d
65 – 69.9 B- Passe
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d
60 – 64.9 C+ Passed
55 – 59.9 C Passed
50 – 54.9 D+ Failed
45 – 49.9 D Failed
0 – 44.9 E Failed

Academic Integrity Statement

i3L does not tolerate acts of cheating, plagiarism, falsification, multiple submissions, attempting or
assisting with an academic integrity violation. If i3L becomes aware of a potential academic integrity
violation and should determine, after consultation with the student, that an academic integrity violation
has taken place, i3L reserve the right to assign a grade penalty up to and including an F for the course.
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Lesson Plan/Satuan Acara Perkuliahan (SAP)

Please note that the following is subject to change without prior notice.

Learning Outcome Study program learning outcome covered by the course

SPLO1 Able to interpret proteomics applications CB4, B5
SPLO2 Able to utilize the latest computational methods for extraction of information on omics-based data CB9, MS4
SPLO3 Able to apply a text processing algorithm for protein sequence alignment and structural comparisons
SPLO4 Able to explain the programming logic and the latest trends in ICT applications in life science
Course learning outcomes
CLO1 Elaborate the fundamentals of population genetics.
CLO2 Determinate the genotype and phenotype frequencies and its affecting factors.
CLO3 Explain the major forces of evolution and its impact on population level.
CLO4 Explain the ecological and evolutionary factors that influence the genetic structure of populations.
CLO5 Identify relevant question formulations in population genetics and propose strategies to solve the problems.
Learning Goals
LG1 Explain the fundamentals of population genetics and Mendelian genetics
LG2 Understand the genotype and phenotype frequency under Hardy-Weinberg equilibrium
LG3 Understand the 5 major evolutionary forces
LG4 Explain the effect of population size to the evolutionary forces
LG5 Understand the quantitative trait loci
LG6 Explain the molecular aspect of evolution
Correlation of CLO with LG
LG1 LG2 LG3 LG4 LG5 LG6
CLO1 √ √
CLO2 √ √
CLO3 √
CLO4 √ √ √ √
CLO5 √ √
Course Description This course will look at the genetic variations within a population by examining and modeling of changes in the frequency of genes and
alleles of time and space. Mathematical models will be applied to track changes, such as selection induced, drift, hitch-hiking genes,
recombination and mutation events, inbreeding and selfish genetic elements. Teaching and learning process will be conducted using
collaborative learning (CL), Problem Based Learning (PBL), and group discussion (GD).
Subject matters: 1. Case studies in each major evolutionary forces
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Learning materials 2. Case studies in genetics and mendelian genetics

3. Case studies in molecular evolution
References Main :
1. Hamilton, M. 2009. Population Genetics. Wiley-Blackwell Pub.: USA. ISBN: 978-1405132770.
2. Hartl, D. L. & A. G. Clark. 2006. Principles of Population Genetics 4th Edition. Sinnauer Associates Inc.: USA. ISBN: 978-0878933082
Supporting :
1. Allendorf, F. W., G. H. Luikart, & S. N. Aitken. 2012. Conservation and the Genetics of Populations. Wiley-Blackwell Pub.: USA.
ISBN: 978-0470671450

Form of learning,
Assessment method of learning, Score
Learning materials
Session Learning Goals learning assignment [Estimated time] weight
[Reference]
(%)
Indicator Criteria & Technique Offline Online
(1) (2) (3) (4) (5) (6) (7) (8)
1,2 LG1: Explain the 1.1. Accuracy in Criteria:  Lecture -  Hartl & Clark
fundamentals of explaining the Marking Scheme  Discussion (2006) – Ch.1
population genetics and central [LP: 1x(2x50”)]  Hamilton (2009)
Mendelian genetics dogma of Non-Test Technique:  Assignment 1: – Ch.1
biology and Summarizing lecture Pedigree and  Allendorf et al
gene notes and discussion Mendelian genetics (2012) – Part 1
expression activity worksheet [SA+IA:
1.2. Accuracy in (1+1)x(2x60”)]
explaining
the
fundamental
s of
population
genetics
1.3. Accuracy in
explaining the
first and
second law of
Mendelian
inheritance
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3,4 LG2: Understand the 1.1. Accuracy in Criteria:  Lecture -  Hartl & Clark
genotype and phenotype explaining the Marking Scheme  Discussion (2006) – Ch.1 & 3
frequency under Hardy- Explain the [LP: 1x(2x50”)]  Hamilton (2009) –
Weinberg equilibrium genotype Non-Test Technique:  Assignment 2: Hardy Ch.2
frequencies Summarizing lecture Weinberg and genetic  Allendorf et al
and the notes and discussion linkage worksheet (2012) – Part 2
affecting activity [SA+IA: (1+1)x(2x60”)]
factors:
Hardy-
Weinberg
Equilibrium
1.2. Accuracy in
explaining
the gene
linkage and
its effect on
genotype
frequency
1.3. Explaining the
mapping of a
certain gene
in a
chromosome
5,6,7,9 LG3: Understand the 5 1.1. Accuracy in Criteria:  Lecture -  Hartl & Clark (2006) 5
10,11 major evolutionary forces explaining Marking Scheme  Discussion – Ch.1 - 6
about the [LP: 1x(2x50”)]  Hamilton (2009) –
effect of 5 Non-Test Technique:  Assignment 3: Major Ch.2 -7
major Summarizing lecture evolutionary forces  Allendorf et al (2012)
evolutionary notes and discussion worksheets and case – Part 2 & 3
forces to a activity studies
population’s Quiz 1  [SA+IA: (1+1)x(2x60”)]
genotype and
phenotype
frequencies
1.2. Accuracy in
explaining
about the
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models to
predict the
effect of the 5
major
evolutionary
forces.
8 Mid Exam 35
12 LG4: Explain the effect of 1.1. Accuracy in Criteria:  Lecture -  Hamilton (2009) – 5
population size to the explaining Marking Scheme  Discussion Ch.3
evolutionary forces about how [LP: 1x(2x50”)]  Hartl & Clark
the Non-Test Technique:  Assigment 4: Effective (2006) – Ch.3
population Summarizing lecture population size  Allendorf et al
size effect on notes and discussion worksheets (2012) – Part 3
evolutionary activity [SA+IA: (1+1)x(2x60”)]
process Quiz 2
1.2. Accuracy in
explaining
about the
models used
to calculate
the effective
population
sizes
13 LG5: Understand the 1.1. Accuracy in Criteria:  Lecture  Hamilton (2009) – 5
quantitative trait loci explaining Marking Scheme  Discussion Ch.9
about the [LP: 1x(2x50”)]  Hartl & Clark
basis of Non-Test Technique:  Assignment 5: (2006) – Ch.8
quantitative Summarizing lecture Quantitative trait loci  Allendorf et al
trait loci notes and discussion worksheet [SA+IA: (2012) – Part 2
1.2. Accuracy in activity (1+1)x(2x60”)]
explaining the Presentation
application of Quiz 2
QTL theory
14,15 LG6: Explain the molecular 1.1. Elaborate the Criteria:  Lecture  Hamilton (2009) – 5
aspect of evolution theories of Marking Scheme  Discussion Ch.8
the molecular [LP: 1x(2x50”)]  Hartl & Clark
aspect of Non-Test Technique: Assignment 6: (2006) – Ch.7
evolution Summarizing lecture Molecular evolution  Allendorf et al
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1.2. Accuracy in notes and discussion worksheet [SA+IA: (2012) – Part 3

explaining the activity (1+1)x(2x60”)]
molecular Presentation
clock system
16 Final exam 40

Note:

Examples of form of Time estimation Examples of method of learning

learning (minute/week/semester
) of 1 CU
LP (Learning Process) 50 minutes Student presentation, group discussion,
debate
SA (Structured assignment) 60 minutes Project-based learning, case study,
collaborative learning
IA (Independent activity) 60 minutes Literature review, summarizing

Approval

Date of approval (25 November 2021)

Prepared by Reviewed by Approved by

Program Coordinator Quality Assurance Unit HoD
Signature
Name

David Agustriawan.,PhD
Rizky Nurdiansyah, S.Si., M.Si

Log of Revisions

Year of Review Revisions Revised by Reviewed by Approved by

 FR-i3L-AA-2021-01-Rev.1

ODD 2021-2022 Formatting Signature Signature

revision
Name Name

Quality Assurance Unit HoD

Rizky Nurdiansyah,
S.Si., M.Si

Program Coordinator