CLASSIFICATION DRUG NAME INDICATION ADVERSE EFFECT

Antidiabetic SHORT ACTING

Agents
Regular Insulin - Type 1 and 2 - Hypokalemia
diabetes - Hypoglycemia
- Allergic reactions
- Heart failure
Humulin R - Type 1 and 2 - Hypokalemia
diabetes - Hypoglycemia
- Allergic reactions
- Lipodystrophy
Novolin R - Type 1 and 2 - Hypokalemia
diabetes - Hypoglycemia
- Allergic reactions
- Lipodystrophy
INTERMEDIATE
ACTING
NPH Insulin - Type 1 and Type 2 - Nocturnal
Diabetes hypoglycemia
- Fasting Hyperglycemia
- Weight gain
- Hypersensitivity
reaction
Lente Insulin - juvenile diabetes - hypoglycemia
mellitus - hyperglycemia
- hypersensitivity
reaction
Humulin N - Type 1 or type 2 - hypoglycemia
Diabetes mellitus - hypersensitivity
reaction
- lipodystrophy

Actrapid N - Treatment for - Hypoglycemia

diabetic mellitus
LONG ACTING - Diabetes Mellitus - Hypoglycemia
INSULIN
Humulin U
Ultralente Insulin - Diabetes Mellitus - Hypoglycemia
Oral Hypoglycemic
Agents
SULFONYUREAS - Adjunct to diet for - Hypoglycaemia
Tolbutamide the management - Nausea
(Orinase) of type 2 diabetes - Epigastric fullness
- Adjunct to insulin - Heartburn
for management - SIADH
of certain type 2
diabetes
- Reducing the
insulin dose and
decreasing the risk
for hypoglycemia
Acetohexamide - Type 2 diabetes - Low blood sugar
(Dymelor) - Weight gain
- Excess urination
Chlorpropramide - Adjunct to diet for - Severe Hypoglycemia
(Diabenese) the management - G.I Disturbances
of type 2 diabetes - Vague Neurologic
Symptoms
Tolazamide - Adjunct to diet for - Hypoglycemia
(Tolinase) the management - Nausea and Vomiting
of type 2 diabetes - Intestinal Gas
- Adjunct to insulin - Hyponatremia
for management - SIADH
of certain type 2
diabetes
- Reducing the
insulin dose and
decreasing the risk
for hypoglycemia

Glimiperide - Adjunct to diet, - Hypoglycemia

(Amaryl) exercise in the - GI hemorrhage
management of - Cholestatic hepatic
type 2 diabetes jaundice
mellitus. - Leukopenia
- Thrombocytopenia
- Pancytopenia
- Agranulocytosis
- Aplastic or hemolytic
anemia (rare)
Glipizide - Adjunct to diet, - Hypoglycemia
(Glucotrol) exercise in - GI hemorrhage
management of - Cholestatic hepatic
type 2 diabetes jaundice
mellitus. - Leukopenia
- Thrombocytopenia
- Pancytopenia
 - Agranulocytosis
- Aplastic or hemolytic
anemia (rare)
Glyburide (Diabeta) - Adjunct to diet, - Hypoglycemia
exercise in - Cholestatic jaundice
management of - Leukopenia
stable, mild to - Thrombocytopenia
moderately severe - Pancytopenia
type 2 diabetes - Agranulocytosis
mellitus. - Aplastic or hemolytic
anemia (rare)
ORAL BIGUANIDES - Management of - Lactic acidosis
Metformin type 2 diabetes (unexplained
(Glucophage) mellitus as hyperventilation,
monotherapy or myalgia, malaise,
concomitantly drowsiness and may
with oral advance to
sulfonylurea or cardiovascular
insulin. collapse or shock,
acute heart failure,
acute myocardial
infarction, or prerenal
azotemia.
THYROID
HORMONES
Levothyroxine - PO: Treatment of - Hyperthyroidism
(Synthroid) hypothyroidism, - Cardiac arrhythmias
pituitary thyroid- - Decreased bone
stimulating mineral density
hormone (TSH)
suppression.
- IV: Myxedema
coma.
Liothyronine - As replacement or - Congestive heart
Sodium (Cytomel) supplemental failure
therapy in - Hypertension
patients with - Phlebitis
hypothyroidism. - Angina
- Treatment or - Fever
prevention of
various types of
euthyroid goiters,
including thyroid
nodules, subacute
or chronic
lymphocytic
thyroiditis
 (Hashimoto's) and
multinodular
goiter.
Liotrex (Thyrlar) - As replacement or - Arrhythmias
supplemental - Increased blood
therapy in pressure
patients with - Chest pain
hypothyroidism. - Anxiety
- Treatment or - Headache
prevention of - Insomnia
various types of - Tachycardia
euthyroid goiters, - Cramps
including thyroid - Weight loss
nodules, subacute - Diarrhea
or chronic
lymphocytic
thyroiditis
(Hashimoto's) and
multinodular
goiter, and
management of
thyroid cancer.
Thyroglobulin - For the treatment - Headache (severe) in
(Proloid) of children
hypothyroidism. - Skin rash or hives
- Chest pain
- Confusion
- Psychosis
- Shortness of breath

References:

Saunders Nursing Drug Handbook 2019

Amy M. Karch, Focus on Nursing Pharmacology, 7 th Ed.

Brunner & Suddart’s Medical Surgical Nursing, 14 th Ed., Chapter 51