THE OXIDATIVE STRESS AND ANTIOXIDANT STATUS

FOUND IN PROSTATE CANCER, PROSTATITIS AND

BENIGN PROSTATIC HYPERPLASIA

A SEMINAR PRESENTED

BY

ORADUBANYA UCHECHUKWU T
IMT/SLT/STH/H2020/8/029

DEPARTMENT OF SCIENCE LABORATORY TECHNOLOGY

SCHOOL OF TECHNOLOGY

INSTITUTE OF MANAGEMENT AND TECHNOLOGY (IMT)

ENUGU

SUPERVISOR: MR. EZEUGWU F.O

JUNE, 2022
 TABLE OF CONTENTS

Title page i
Table of contents ii
Abstract iii
CHAPTER ONE
1.0 Introduction 1
1.1 Background of study 1
CHAPTER TWO
2.1 prostatitis 3
2.2 benign prostatic hyperplasia (BPH) 4
2.3 prostate cancer 5
CHAPTER THREE
3.1 Antioxidants 7
3.2 Types of antioxidants 7
3.3 Concept of oxidative stress 11
3.4 Roles of antoxidant/oxidative stress in diseases 11
3.5 Antioxidant Status in Prostate Cancer, Prostatitis and BPH 16
CHAPTER FOUR
4.1 Conclusion 18
4.2 Recommendations 18
References 19
 ABSTRACT

Antioxidant levels are decreased in benign prostate hyperplasia and

prostate cancer patients. The resulting oxidant-antioxidant imbalance
suggests that patients with prostate disorders are exposed to a lot of
oxidative stress which may be one of the factors responsible for the
development of BPH and prostate cancer. Assessing the antioxidant levels
in the patients with these prostatic disorders may assist in their proper
management and reducing disease morbidity. Thus, there may be need for
antioxidants supplementation in the management of these patients since
antioxidant deficiency may be associated with more cellular degeneration,
cancer progression, and poor prognosis.