 Clinical Study

 Published: 24 July 2020

Pediatric primary central nervous system

tumors registry in Thailand under National
Health Security Office schemes
 Bunchoo Pongtanakul, 
 Nongnuch Sirachainan, 
 Pacharapan Surapolchai, 
 Pimlak Charoenkwan, 
 Worawut Choeyprasert, 
 Patcharee Komwilaisak, 
 Su-on Chainansamit, 
 Nittaya Witsanuyothin, 
 Yujinda Lertrakul, 
 Piya Rujkijyanont, 
 Somjai Kanjanapongkul, 
 Darintr Sosothikul, 
 Kleebsabai Sanpakit, 
 Thirachit Chotsampancharoen, 
 Somporn Wangruangsathit, 
 Nintita Sripaiboonkij Thokanit, 
 Sommaphun Tabjareon& 
 Suradej Hongeng 

Journal of Neuro-Oncology volume 149, pages 141–151 (2020)Cite this article

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Abstract
Background
Few epidemiological studies of pediatric central nervous system (CNS) tumors
have been performed using data from Southeast Asian national registries.
Therefore, we aimed to examine data on CNS tumors from the first national
childhood CNS tumor registry in Thailand.

Methods
Newly diagnosed children with benign and malignant primary CNS tumors
from 20 nationwide hospitals were included. Two eras in the Thai registry were
studied to compare national protocol effectiveness, including 2003–2005
(before establishment of a pediatric CNS tumor protocol) and 2011–2012
(post-establishment).

Results
The first study period had 300 patients with an incidence of 7.5/1,000,000
person-years and the second had 168 patients with an incidence of
13.24/1,000,000 person-years. The three most common tumors were gliomas,
medulloblastoma/primitive neuroectodermal tumor (PNET), and germ cell
tumors. The most common tumor site was the cerebellum, followed by the
brainstem and pineal region. Five- and 10-year overall survival (OS) rates were
46.62% (95% confidence interval [CI] 40.85–52.18) and 41.78% (95% CI 36.11–
47.34), respectively, for the first period. The second period had a 5-year OS of
64.75% (95% CI 56.70–71.68). OS rates for gliomas, germ cell tumors,
medulloblastoma/PNET, and ependymomas were better in the second period
than in the first period.

Conclusions
The incidence of primary childhood CNS tumors in our study is lower
compared with other reports. Improvement of OS in the second study period
might be because of establishment of the Thai Pediatric Oncology Group, and
national protocols for childhood CNS tumors.
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Acknowledgements
This study was financial supported by Ramathibodi Foundation, Children
Cancer Fund under The Patronage of HRH Princess Soamsawali and My Child
Matters Grant Award UICC awarded to Dr. Suradej Hongeng, and National
health security office of Thailand. We thank Ellen Knapp, PhD, from Edanz
Group (https://www.edanzediting.com/ac) for editing a draft of this manuscript.
Author information
Authors and Affiliations
1. Department of Pediatrics, Faculty of Medicine Siriraj Hospital,
Mahidol University, Bangkok, 10700, Thailand
Bunchoo Pongtanakul, Kleebsabai Sanpakit & Sommaphun Tabjareon
2. Department of Pediatrics, Faculty of Medicine Ramathibodi
Hospital, Mahidol University, Bangkok, 10400, Thailand
Nongnuch Sirachainan & Suradej Hongeng
3. Department of Pediatrics, Faculty of Medicine, Thammasat
University, Pathumthani, 12120, Thailand
Pacharapan Surapolchai
4. Department of Pediatrics, Faculty of Medicine, Chiang Mai
University, Chiang Mai, 50200, Thailand
Pimlak Charoenkwan & Worawut Choeyprasert
5. Department of Pediatrics, Faculty of Medicine, Khon Kaen
University, Khon Kaen, 40002, Thailand
Patcharee Komwilaisak
6. Department of Pediatrics, Khon Kaen Hospital, Khon Kaen, 40000,
Thailand
Su-on Chainansamit
7. Department of Pediatrics, Nakhon Ratchasima Hospital, Nakhon
Ratchasima, 30000, Thailand
Nittaya Witsanuyothin
8. Department of Pediatrics, Sappasitthiprasong Hospital, Ubon
Ratchathani, 34000, Thailand
Yujinda Lertrakul
9. Department of Pediatrics, Phramongkutklao Hospital, Bangkok,
10400, Thailand
Piya Rujkijyanont
10. Department of Pediatrics, Queen Sirikit National Institute of
Child Health, Bangkok, 10400, Thailand
Somjai Kanjanapongkul
11. Department of Pediatrics, Faculty of Medicine, King
Chulalongkorn Memorial Hospital, Chulalongkorn University,
Bangkok, 10330, Thailand
Darintr Sosothikul
12. Department of Pediatrics, Faculty of Medicine, Prince of
Songkla University, Hat Yai, Songkhla, 90110, Thailand
Thirachit Chotsampancharoen
13. Department of Pediatrics, Buddhachinaraj Phitsanulok
Hospital, Phitsanulok, 65000, Thailand
 Somporn Wangruangsathit
14. Ramathibodi Comprehensive Cancer Center, Faculty of
Medicine Ramathibodi Hospital, Mahidol University, Bangkok,
10400, Thailand
Nintita Sripaiboonkij Thokanit
Corresponding author
Correspondence to Suradej Hongeng.
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Cite this article

Pongtanakul, B., Sirachainan, N., Surapolchai, P. et al. Pediatric primary central
nervous system tumors registry in Thailand under National Health Security
Office schemes. J Neurooncol 149, 141–151 (2020).
https://doi.org/10.1007/s11060-020-03582-w
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 Received15 May 2020

 Accepted11 July 2020
 Published24 July 2020
  Issue DateAugust 2020
 DOIhttps://doi.org/10.1007/s11060-020-03582-w
Keywords

 Asia

 CNS tumor

 Developing country

 Pediatrics

 Registry

 Thailand
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