4/2/22, 12:23 PM Electron Microscopy

Electron Microscopy
Anatomy-Histology main menu.

The following grayscale electron micrographic images are available [file sizes
average 100 to 160k]:

Normal Structures

Structure Description

Neutrophil Normal polymorphonuclear leukocyte

Lymphocyte Normal lymphocyte

Normal plasma cell with prominent cytoplasmic smooth endoplasmic

Plasma cell
reticulum

Normal macrophage with oblong nucleus, nucleolus, and cytoplasm

Macrophage
with a variety of inclusions

Platelets Normal platelets

Mitochondria Happy mitochondria within a cell

Normal skeletal muscle, normal (inset shows a single sarcomere

Skeletal
with dark Z discs, and a central M line, with thin actin and thick
muscle
myosin filaments)

Collagen Normal collagen fibrils

Cilia Normal cilia of respiratory tract epithelium

Miscellaneous Findings

Structure Description

Amyloid Amyloid fibrils, with inset demonstrating array of fibrils

Adrenoleukodystrophy, adrenal gland, with long parallel

Adrenoleukodystrophy
inclusions of long chain fatty acids

Birbeck granules (inset shows several at higher

Birbeck granules
magnification) from a case of histiocytosis X

Histiocytosis X Cell with a clefted nucleus from a case of histiocytosis X

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Bacteria Pseudomonas bacteria

Cryptosporidia Cryptosporidia along small intestinal brush border

Herpes simplex virus in brain, viral particles (inset) in

Herpes simplex virus
nucleus

Progressive multifocal leukoencephalopathy (PML) with

JC papovavirus JC virus in brain, small round dark viral particles in
nucleus

Human immunodeficiency virus, viral particles at low

HIV-1
magnification adjacent to cell surface

Human immunodeficiency virus, viral particles at medium

HIV-1
magnification

Human immunodeficiency virus, viral particle budding

HIV-1 from cell surface at top, and complete viral particle at
bottom, high magnification

Inclusion body
Skeletal muscle with inclusion body myositis
myositis

Nemaline myopathy Skeletal muscle with nemaline rods

Ciliary dyskinesis Respiratory tract cilia lacking dynein arms

Neoplasms

Structure Description

Adenocarcinoma with several features typical of a neoplasm of

epithelial origin, including a junctional complex (tight junction at
Adenocarcinoma
asterisk, desmonsomes at crosses, and a mucin granule M) and
lumenal microvilli at the upper right

Junctional Junctional complex, higher magnification, with tight junction at

complex right and desmosomes at left

Squamous cell Squamous cell carcinoma with many desomosomes and

carcinoma cytoplasmic tonofilaments streaming to the left

Microvilli seen in cell from adenocarcinoma of the colon (inset

Microvilli shows the dense core rootlets below and the rounded
glycocalyceal bodies in the villi above

Intracytoplasmic Intracytoplasmic lumen in a cell from metastatic carcinoma of

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lumen breast

Leiomyosarcoma demonstrating cytoplasmic filaments with

condensations to the left of the nucleus, a lipid body at the far
Leiomyosarcoma left, and subplasmalemmal filament condensations and
pinocytotic vesicles near nucleus at the right (also seen in the
inset)

Mesothelioma Mesothelioma of pleura with long, curved microvilli

Ewing's sarcoma of bone with extensive cytoplasmic glycogen

Ewing's sarcoma
deposits

Premelanosomes from a malignant melanoma, composite of two

Premelanosomes
cases

Melanosomes (inset shows the dark oblong melanosomes in

Melanosomes
more detail) from a malignant melanoma

Adrenal Large mitochondria with tubular cristae above normal

carcinoma mitochondria in a cell from adrenal cortical carcinoma

Neurosecretory Neurosecretory granules (some with a thin surrounding halo) in

granules a neuroendocrine neoplasm

Renal Lesions

Structure Description

Minimal change disease (MCD) with effacement of

Minimal change disease
podocyte foot processes

Post-streptococcal Post-streptococcal glomerulonephritis with

glomerulonephritis hypercellularity

Membranous Membranous nephropathy with thickened glomerular

nephropathy basement membrane containing electron dense deposits

Lupus nephritis "Fingerprint" with lupus nephritis

Membranoproliferative
Membranoproliferative glomerulonephritis, type I with
glomerulonephritis, type
splitting and reduplication of basement membrane
I

Dense deposit disease Dense deposit disease with dense deposits

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