the intestine microbiome

To apprehend what this interplay among IAA and S100A8 way functionally, the researchers fed
IAA to younger mice. Then they ran the mice thru 3 behavioral and cognitive assays. Young
mice that have been fed IAA executed worse at the tasks, which blanketed navigating mazes
and spotting objects, than did untreated younger controls. The have a look at authors propose
that microglial mobileular activation might also additionally effect the downstream characteristic
of neurons in direct or oblique ways, as IAA promoted neuronal loss and neuron dying
withinside the brains of younger mice. Neuropathologist Thomas Blank of the University Clinic
Freiburg in Germany, who become now no longer in concerned withinside the have a look at,
writes in an e-mail to The Scientist that “the proof strongly shows that IAA is a thing in cognitive
decline.”

“The identity of age-associated shifts withinside the intestine microbiome in humans, which
brought on will increase in a bacterial metabolite, isoamylamine, that may without delay bind to
genomic DNA withinside the mind of mice is virtually exciting,” Melanie Gareau, a researcher
running at the microbiota-intestine-mind axis on the University of California, Davis, who become
now no longer concerned withinside the have a look at, writes in an e-mail to The Scientist.