COURSE OUTLINE

1st Semester 2022-2023

Course Information:
Course Title: Hematology 1
No. of units: 3 units lecture, 2 laboratory
Pre-requisite Subject/s None
Class Schedule: TTh
A. Lecture 3-4:30 PM
B. 1:30-3 PM
Venue: N9
Faculty Information:
Name:
Degree: Bachelor of Science in Medical Technology- MVC
Office: School of Medical Technology
Contact number:
Email Address:
Consultation Hours: Mondays, Wednesday

Course Description:
The lectures of this course are describing the basic concepts of hematology with principles of blood testing; both manual and currently available
fully automated diagnostic tools. The course includes definition of the science of hematology, hematopoiesis, blood components and function
etc. In addition, the manual automations in hematology and the common pathological blood disorders will also be covered.

STUDENT INTENDED LEARNING OUTCOMES:

By the end of this course, the students SHOULD be able to:
1. Understand the principles of hematology, both blood physiology, functions, and disorders.
2. Master the pathobiology of hematological disorders encountering in hospital practice.
3. Interpret diagnostic test results and erroneous test results and able to fix them.
COURSE OUTLINE AND SCHEDULE
DATES TOPIC PEDAGOCICAL ACTIVITIES MATERIALS NEEDED
Week 1 1. Anatomy and Physiology of bone marrow Lecture:  Lecture handouts
 Ontogeny of hematopoiesis Lecture/Discussion  PowerPoint slides
 Stem cell biology and hematopoietic PowerPoint presentation  Book
differentiation pathways
 Control of hematopoiesis roles of Post-test
cytokines, growth factors and bone
marrow microenvironment (niches)
 Bone marrow failure: Aplastic anemia
Week 2 2. Erythropoiesis Pre-test  Lecture handouts
 Normal red cell structure (including Lecture:  PowerPoint slides
membrane cytoskeleton) Lecture/Discussion  Book
 Normal red cell metabolism (including PowerPoint presentation
generation of ATP, 2,3 DPG and Group Dynamics
antioxidant defense)
 Normal hemoglobin (structure and
function)
 Red cell senescence and removal by RE
system
Week 3 3. Leucopoiesis Lecture:  Lecture handouts
 Normal function of granulocytes, Lecture/Discussion  PowerPoint slides
monocytes and lymphocytes; PowerPoint presentation  Book
 Anatomy of immune system (primary and
secondary lymphoid organs) Post-test
 Innate immunity and the inflammatory
response
Week 4 4. Anemia: Pre-test  Lecture handouts
 Definition; Pathophysiology and clinical Lecture:  PowerPoint slides
signs/symptoms Lecture/Discussion  Book
 classification by cause PowerPoint presentation
 morphological classification
 Erythrocytosis Causes and differential
 diagnosis
PRE-LIM EXAM
Week 5 5. Iron metabolism Red cell disorders Lecture:  Lecture handouts
relating to iron: Lecture/Discussion  PowerPoint slides
 Iron deficiency anemia PowerPoint presentation  Book
 Anemia of chronic inflammation
 Sideroblastic anemia Post-test
 Haemochromatosis and other iron
overload disorders
Week 6 6. Megaloblastic anemia due to vit B12 or Pre-test  Lecture handouts
folate deficiency Hemolytic anemia Lecture:  PowerPoint slides
 Definition Lecture/Discussion  Book
 Hereditary causes (spherocytosis, PowerPoint presentation
elliptocytosis, enzymopathies, etc.)
 Acquired causes (immune, non-
immune including malaria and PNH)
Week 7 7. Genetic disorders of hemoglobin: Lecture:  Lecture handouts
 Structure of the hemoglobin genes Lecture/Discussion  PowerPoint slides
 Thalassemia syndromes PowerPoint presentation  Book
 Structural haemoglobinopathies
Post-test
MIDTERM EXAM
Week 8 8. Non-malignant white cell disorders: Pre-test  Lecture handouts
 Secondary leukocytosis and effects of Lecture:  PowerPoint slides
bacterial / viral infection (including Lecture/Discussion  Book
infectious mononucleosis) PowerPoint presentation
 Agranulocytosis
 Molecular pathogenesis of leukemia.
Week 9 9. Acute leukemias Lecture:  Lecture handouts
 Classification: FAB / WHO Lecture/Discussion  PowerPoint slides
Myelodysplastic syndromes PowerPoint presentation  Book
 Classification: FAB / WHO Aspects of
treatment (chemotherapy – targeted and Post-test
nontargeted; HSC transplantation)
Week 10 10. Chronic myeloid leukemia Pre-test  Lecture handouts
Myeloproliferative disorders (PV, ET, MF) Lecture:  PowerPoint slides
Lecture/Discussion  Book
PowerPoint presentation

Week 11 11. Lymphoproliferative disorders: Lecture:  Lecture handouts

 Chronic lymphocytic leukemia Lecture/Discussion  PowerPoint slides
 Hodgkin’s lymphoma PowerPoint presentation  Book
 Non-Hodgkin’s lymphoma Multiple
Myeloma / Walden Troms Post-test
macroglobulinemia
SEMI-FINAL EXAM
Week 12 12. Haemostasias: Pre-test  Lecture handouts
 Components of haemostasias system Lecture:  PowerPoint slides
Haemostasias mechanisms Lecture/Discussion  Book
PowerPoint presentation

Week 13 13. Bleeding disorders Lecture:  Lecture handouts

 Hereditary coagulation defects Lecture/Discussion  PowerPoint slides
 von Willebrand’s disease PowerPoint presentation  Book
14. Platelet disorders
 Thrombocytopenia (immune and non- Post-test
immune)
 Functional disorders (hereditary and
acquired)
 Acquired haemostasias disorders
(DIC, ,liver disease, TTP)
Week 14 15. Thrombotic disorders Thrombophilia Pre-test  Lecture handouts
(hereditary and acquired eg APS) Lecture:  PowerPoint slides
 Lecture/Discussion  Book
PowerPoint presentation

Week 15 16. Therapeutic aspects of haemostasias: Lecture:  Lecture handouts

Anticoagulant therapy Lecture/Discussion  PowerPoint slides
 Heparin PowerPoint presentation  Book
 Warfarin
 New oral anticoagulants
FINAL EXAM