MODE OF

ACTION OF
INSECTICIDES
GROUP 1
BSA 3B
 Insecticides are divided into
many groups according to their
chemical composition.

Introduction Each insecticide group interfere

and interact uniquely with
different target sites , although
different group may share the
same mode of action.
 Nicotinic acetylcholine
1 receptors (nAChR)

Acetylcholine
and its 2 Muscarinic acetylcholine
receptors (mAChR)

Receptors
Services 03
I. Acetylcholine
and its
Receptors
Released by the synaptic
vesicles of presypnaptic
neurons binds to their
receptors in the postsynaptic
neuron.
Nicotinic Prevalent in insect's nervous
system, usually found on cell
Acetylcholine bodies of interneurons, motor
neurons, and sensory neurons.

Receptors Present on mammals, located in

the brain and skeletal muscles.
(nAChR)
Muscarinic These receptors are called as
Acetylcholine such for they are particularly
more responsive to muscarine.
Receptors
(mAChR)
 1 Ryanodine Receptors (RyRs)

Some
Important 2 Chloride Channels
Channels and
Receptors
3 Octopamine Receptors
 A class of intracellular calcium
Ryanodine channels found in the terminals of the
neurons and muscles.
Receptors The release of calcium ions from these
channels into the protein filaments of
(RyRs) a muscle result to the latter's
contraction.
 These channels mediate the release of

Chloride chloride ions (C1-).

Depending on the neurotransmitter

Channels that binds t o it, a chloride channel
can be clasified as GABA-gated
chloride channels or glutamate-gated
chloride channels.
a. GABA-gated Chloride
Channels (GABAA)
These channels are primarily found in the
insect's central nervous system; as the name
implies , they open in response to the binding
of GABA (y- aminobutyric acid).
b. Glutamate-gated Chloride
Channels
Obseved to be present in insects and
nematodes only, are distributed throughout
the insect's nervous system and muscle.
 Open in response to octopamine
Octopamine binding.

Receptors It is a modulatory neurotransmitter

that regulates behavioral arousal
within the central nervous system.
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