Problem set on pp.308 – 312 Nos.

11, 22, 28, 29, 39, 41, 49, 53, 61, 64

✅
11. How many milliliters of water must be added to 250 mL of a 25% w/v stock solution of
sodium chloride to prepare a 0.9% w/v sodium chloride solution?
25% 0.9 parts sodium chloride
0.9%
0% 24.1 parts water

9 parts sodium chloride solution: 241 parts water = 250 parts sodium chloride solution
9:250mL = 241:x
x=
=6694.4 mL of water

22. If a pharmacist fortified 10 g of a 0.1% w/w tacrolimus (PROTOPIC) ointment by adding

✅
12.5 g of an ointment containing 0.03% w/w of the same drug, what would be the percentage
strength of the mixture?
10g x 0.001 = 0.01
12.5g x 0.0003 = 0.00375
22.5g 0.01375
0.01375
%𝑤/𝑤 = 22.5𝑔
× 100 = 0. 06%

✅
28. A pharmacist receives a prescription for 60g of a 0.75% w/w bexarotene gel. How many
grams of each of a 1% w/w bexarotene gel and gel base must be used?
1% 0.75
0.75%
0% 0.25

3 parts bexarotene gel:1 part of gel base = 4 parts of bexarotene gel

3: x = 4: 60g
= 45g bexarotene gel
1: x = 4: 60g
= 15g gel base

29. As a part of a clinical study, a pharmacist is asked to prepare a modification of a

standard 22g package of a 2% mupirocin ointment by adding the needed quantity of

✅
mupirocin powder to prepare a 3% w/w mupirocin ointment. How many milligrams of
mupirocin powder are required?

100% 1 powder
3%
2% 97 ointment
1:97 = 98
97:22g = 1: x
X = 0.227g x 1000mg/g = 227mg mupirocin powder
 ✅
39. How many grams of an ointment base must be added to 45 g clobetasol ointment, 0.05%
w/w, to change its strength to 0.03% w/w?

0.05% 0.03 parts clobetasol ointment

0.03%
0% 0.02 parts ointment base
3:2 = 5 parts clobetasol ointment
3: 45g = 2 : x
X = 30g ointment base

✅
41. How many milliliters of a non medicated, flavored syrup base must be added to 1 pint of
ranitidine syrup, 15 mg/mL, to change its concentration to 5mg/mL?

1 pt - 473 mL
15mg/mL 5 ranitidine syrup
5mg/mL
0mg/mL 10 syrup base
1:2 = 3
1: 473mL = 2: x
X = 946 mL syrup base

49. A hospital worker combined 2 fluid ounces of a povidone-iodine cleaner, 7.5% w/v, with 4

✅
fluid ounces of a povidone-iodine topical solution, 10% w/v. Calculate the resulting strength
of the povidone-iodine mixture.

(2x29.57mL) x 0.075 = 4.4355 g

(4x29.57mL) x 0.10 = 11.828 g
177.42mL = 16.2635 g
16.2635𝑔
%𝑤/𝑣 = 177.42𝑚𝐿
× 100 = 9. 17%
9.17% w/v

✅
53. In what proportion should a 20% zinc oxide ointment be mixed with white petrolatum
(diluent) to produce a 3% zinc oxide treatment?
20% 3 parts zinc oxide ointment
3%
0% 17 parts white petrolatum

3:17

61. What is the specific gravity of a mixture containing 1000 mL of water, 500 mL of glycerin

✅
having a specific gravity of 1.25, and 1500 mL of alcohol having a specific gravity 0.81?
(Assume no contraction occurs when the liquids are mixed.)

1000mL x 1 = 1000g
500mL x 1.25 = 625g
1500 mL x 0.81 = 1215g
3000mL 2840g
 2840𝑔
𝑆𝑝. 𝑔𝑟. = 3000𝑚𝐿
= 0. 947

64. How many grams of sorbitol solution having a specific gravity of 1.285 and how many

✅
grams (milliliters) of water should be used in preparing 500 g of a sorbitol solution having a
specific gravity of 1.225?
1.285 0.225 parts sorbitol solution
1.225
1 0.06 parts water

15:4 = 19 parts sorbitol solution

15: x = 19: 500g
X = 394.737 g sorbitol solution

4:x = 19: 500g

X = 105.263 g x 1ml/g = 105.263 mL of water

1
2
3
4
5
6
7
8
9
10