CAMPYLOBACTER

BY

ABDULRAHEEM KEHINDE ZAINAB

20D/57MB/01624

A SEMINAR REPORT SUBMITTED TO THE DEPARTMENT OF MICROBIOLOGY,

FACULTY OF PURE AND APPLIED SCIENCES, KWARA STATE UNIVERSITY
MALETE, KWARA STATE.
IN PARTIAL FUFILLMENT OF THE REQUIREMENT FOR THE AWARD OF BACHELOR
OF SCIENCE (B S c) DEGREE IN MICRIOBIOLOGY.

SEPTEMBER, 2022

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 CERTIFICATION
This is to justify the Seminar entitled “CAMPYLOBACTER” presented by Abdulraheem
Kehinde Zainab with Matric No. 20D/57MB/01624 of Microbiology in Kwara State University,
Malete.

MRS S. A. ABDULMUMINI DATE

(Supervisor)

Prof S.AWE DATE

(Head of Department)

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 DEDICATION
I whole heartedly dedicate this work to God Almighty to the fountain of Wisdom.

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 ACKNOWLEDMENTS
I wish to acknowledge the presence of God Almighty for his grace upon the completion of this
report and I return all the praise to him.
My warmest appreciation goes to my supervisor MRS S. A. ABDULMUMINI for her support
throughout the course of this report.
I wish to express my profound gratitude to my parent Mr and Mrs Abdulraheem for giving me a
shoulder to lean on through these arduous challenge and their unwavering support and also my
beloved friend Faith for her support for the completion of this review.

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 TABLE OF CONTENTS

Title Page No

Title page i

Certification Page ii

Dedication iii

Acknowledgement iv

Table of Contents v

Summary vii

TABLE OF CONTENTS
CONTENT PAGE NO
CHAPTER ONE 1
1.0 INTRODUCTION 1
1.1 Background of Study 2
1.2 Significance of Study 2
CHAPTER TWO 3
2.0 LITERATURE REVIEW 3
2.1 Morphology of Campylobacter 3
2.2 Genomics of Campylobacter 3
2.3 Detection of Campylobacter 4
2.3.1 Detection of Campylobacter in humans 4
2.3.2 Detection of Campylobacter in livestocks 4
2.3.3 Detection of Campylobacter in meats 4
2.3.4 Treatment of Campylobacter 4
2.3.5 Epidemiology of Campylobacter 5
2.4 Clinical Aspect of Campylobacter 7
2.4.1 Campylobacteriosis in Humans 7
2.4.2 Reservoirs and Transmission Routes of Campylobacteriosis 8
2.5 Cause of Campylobacteriosis 10

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2.6 Pathogenesis and Virulence Factors of Campylobacteriosis 10
2.6.1 Motility 11
2.6.2 Adhesion 12
2.6.3 Invasion 13
2.6.4 Toxin Production 13
2.6.5 Carbohydrate Structures 14
2.6.6 Iron Uptake System 15
2.7 Complications and Diagnosis of Campylobacteriosis 16
2.7.1 Other complication factors of Campylobacteriosis 16
2.7.2 Diagnosis of Campylobacteriosis 16
2.8. Survival Strategies of Campylobacter Spp. 18
2.8.1 Biofilms 18
2.8.2 Stress Responses 19
2.8.3 VBNC and Coccoid Forms of Campylobacter 19
2.9 Persistence along Poultry Food Chain 20
2.9.1 Farm 20
2.9.2 Slaughter and Processing Plant 23
2.9.3 Retail 25
2.10 Antimicrobial Resistance 26
2.10.1 Antibiotic Resistance 27
2.10.1.1 Multidrug Efflux Pump System 27
2.10.1.2 Quinolones 28
2.10.1.3 Tetracycline 29
2.10.1.4 Aminoglycoside 29
2.10.1.5 Macrolide 29
CHAPTER THREE 31
3.0 Conclusion 31
3.1 Recommendation

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 SUMMARY
Campylobacter bacteria is a motile, corkscrew-shaped gram-negative rod. They range in size
from 0.5 to 5 microns in length by 0.2 to 0.9 microns in width. While there are dozens of species,
3 represent the main sources of human
infection: Campylobacter jejuni, Campylobacter coli, and Campylobacter lari. C. jejuni is the
most commonly implicated species. Campylobacter species represent one of the most common
causes of bacterial diarrheal illness worldwide. Campylobacter infection is associated with the
consumption of raw milk, undercooked poultry, and contaminated water. Patients typically
experience a self-limited diarrheal illness lasting 5 to 7 days. Immunocompromised and elderly
patients are at the highest risk for morbidity, mortality and prolonged illness. Despite having
treatment and eradication modalities in place in animal reservoirs, there has been a dramatic
increase of cases in developed and underdeveloped regions of the world. This report illustrates
the detection methods of Campylobacter infections, Campylobacteriosis and Antimicrobial
resistance of Campylobacter infections.

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