ADVERSE NURSING

MEDICATION MECHANISM OF INDICATION CONTRAINDICATION

CONSIDERATION
EFFECT
ACTION
Generic Name: Dexamethasone is a -Preterm pregnancy to Use in preterm Dexamethasone is -History for systemic
Dexamethasone potent accelerate surfactant infants may be associated with administration:
glucocorticoid with production associated with an various mild Active infections;
Brand Names: no mineracortoid -Bronchopulmonary increased risk of adverse drug renal or hepatic
Decadron, Dexam property. It exerts is Dysplasia (BPD) cerebral palsy. reactions disease;
ethasone Intensol, action in decreasing -Adrenal Insufficiency Continuous including; Acne, hypothyroidism,
Dexone, TaperDex inflammation by -Croup treatment for over insomnia, weight ulcerative colitis;
, Hexadrol suppressing the -Acute lymphoblastic 10 days can gain, depression diverticulitis; active
migration of cells leukemia produce adrenal or euphoria, or latent peptic
known as -Raised intracranial suppression for 3-4 vertigo, increased ulcer; inflammatory
Dosage Forms: polymorphonuclear pressure weeks. appetite, impaired bowel disease; CHF,
oral concentrate (1 leukocytes of PMN -Brain tumor induced Contraindicated in skin healing, hypertension,
mg/mL); oral liquid and reducing cerebral edema patients who are hypertension, thromboembolic
(0.5 mg/5 mL); oral capillary -Airway edema hypersensitive to vomiting disorders;
tablet (0.5 mg; permeability. -Inflammation any components of confusion, osteoporosis;
0.75 mg; 1 mg; 1.5 -Meningitis this product. amnesia, seizure disorders;
mg; 2 mg; 20 mg; -Spinal cord compression dyspepsia diabetes mellitus;
4 mg; 6 mg) increased risk of lactation
infection. -History for
ophthalmic
preparations: Acute
superficial herpes
simplex keratitis,
fungal infections of
ocular structures;
vaccinia, varicella,
and other viral
diseases of the
cornea and
conjunctiva; ocular
TB
-Physical for
systemic
administration:
Baseline body
weight, T; reflexes,
and grip strength,
affect, and
orientation; P, BP,
peripheral perfusion,
prominence of
superficial veins; R
and adventitious
sounds; serum
electrolytes, blood
glucose
-Physical for topical
dermatologic
preparations:
Affected area for
infections, skin injury
Generic Name: Enoxaparin binds -Thromboembolism Enoxaparin is Hemorrhage, -Contraindicated
Enoxaparin to antithrombin III, prophylaxis contraindicated in skin necrosis, in pork
a serine protease -Thromboembolism patients with heparin-induced hypersensitivity
Brand Name: inhibitor, forming treatment active major thrombocytopeni -Monitor for signs
Lovenox a complex that bleeding in patient a, hyperkalemia, of bleeding
irreversibly with osteoporosis -Administer in
inactivates factor thrombocytopenia and subcutaneous
Xa, which is associated with a hypersensitivity tissue
frequently used to positive in vitro reactions. -DO NOT eject air
monitor test for anti- bubble prior to
anticoagulation in platelet antibody injection
the clinical in the presence of -DO NOT aspirate
setting. Following enoxaparin or massage site
factor Xa sodium, or in
inactivation, patients with
enoxaparin is hypersensitivity to
released and enoxaparin.
binds to other Patients with
anti-thrombin known
molecules. Factor hypersensitivity to
IIa (thrombin) is heparin or pork
directly inhibited products should
by enoxaparin, not be treated
however with less with enoxaparin
potency than injection or any of
unfractionated its constituents.
heparin
(UFH).Due to the
cascade of effects
resulting from
enoxaparin
binding, thrombin
is unable to
convert fibrinogen
to fibrin and form
a clot, preventing
thromboembolic
events.

Generic Name: Pain signals, -It is used to help Lyrica is Commonly Pregabalin can
Pregabalin along with those control certain kinds contraindicated in reported side cause a severe
that cause of seizures. patients with effects of allergic
Brand Names: convulsions or -It is used to treat known pregabalin reaction. Stop
Lyrica, Lyrica seizures, are painful nerve diseases. hypersensitivity to include: taking pregabalin
CR passed from -It is used to pregabalin or any infection, ataxia, and seek
nerve to nerve treat fibromyalgia. of its components. blurred vision, emergency
Dosage through voltage- -It may be given to you Angioedema and constipation, medical help if
Forms: gated calcium for other reasons. Talk hypersensitivity diplopia, you have hives or
oral capsule; channels that with the doctor. reactions have dizziness, blisters on your
oral solution; have alpha-delta occurred in drowsiness, skin, trouble
oral extended subunits. Those patients receiving fatigue, breathing, or
release tablet with alpha-delta pregabalin headache, swelling in your
subunits are therapy. peripheral face, mouth, or
considered HVA edema, tremor, throat.
or high voltage- weight gain, Some people
activated visual field loss, have thoughts
channels. In the accidental about suicide
nerve cell, the injury, and while taking
calcium that xerostomia. Oth pregabalin. Stay
passes through er side alert to changes
these channels effects include: in your mood or
 excites the nerve abnormal gait, symptoms. Report
cell and causes abnormality in any new or
the transmission thinking, worsening
of the signal amnesia, symptoms to your
across the arthralgia, doctor.
synapse to the asthenia, If you have
next nerve cell. cognitive diabetes or heart
dysfunction, problems, call
confusion, your doctor if you
edema, have weight gain
neuropathy, or swelling in your
sinusitis, speech hands or feet
disturbance, while taking
vertigo, visual pregabalin.
disturbance, Do not stop using
myasthenia, pregabalin
amblyopia, suddenly, even if
increased you feel fine.
appetite, and Stopping
twitching. suddenly may
Continue cause withdrawal
reading for a symptoms.
comprehensive
list of adverse
effects.

Generic Name: Omeprazole is a -Omeprazole is Omeprazole is Omeprazole is -Assess the

Omeprazole proton-pump indicated for the short- contraindicated in considered a patient for skin
inhibitor used in term treatment of patients with a benign drug; problems and
Brand Names: the management peptic ulcer disease in history of however, the report the GI
FIRST and treatment of adults, where most hypersensitivity to primary adverse abnormalities to
Omeprazole, several conditions, patients heal within the drug or any effects reported the physician
Omeprazole + including four weeks. excipients from in drug labeling such as nausea,
SyrSpend SF uncomplicated -Patients with the dosage include diarrhea, vomiting
Alka, PriLOSE heartburn, peptic duodenal ulcer form. Hypersensiti headache (6.9% and constipation.
C, PriLOSEC ulcer disease, disease and H. vity reactions like ), abdominal -Assess the
OTC, Zegerid gastrointestinal pylori infection that is anaphylactic pain (5.2%), sensitivity to
(Original reflux disease, active for up to one shock, diarrhea omeprazole to
Formulation) Zollinger-Ellison year may benefit from angioedema, (3.7%), nausea reduce the risk of
syndrome, multiple combination therapy of interstitial (4.0%), vomiting hypersensitivity.
Dosage endocrine omeprazole with nephritis, anaphyl (3.2%), and -Assess
Forms: adenomas, clarithromycin, axis, urticaria, flatulence neurological
Oral delayed systemic amoxicillin, and and bronchospas (2.7%) in adults. status of the
release capsule mastocytosis, metronidazole. Studies m may occur. Other than patient such as
(10 mg; 20 mg; erosive show a reduced According to these adverse orientation level.
40 mg); oral esophagitis, recurrence of product labeling, effects, -Check if the
delayed gastric ulcers, and duodenal ulcers omeprazole is cough, rash, patient is taking
release tablet helicobacter pylori with H. pylori treatment contraindicated in asthenia, back omeprazole
(20 mg); oral infection. This and a reduced rate of patients taking pain, before meals and
powder for activity reviews the clarithromycin dosage forms regurgitation, swallowing the
reconstitution, indications, resistance with containing upper whole capsule.
delayed mechanism of quadruple therapy. rilpivirine. respiratory -Advise the patient
release (10 mg; action, -Omeprazole is also infection, that it is a short-
2.5 mg); oral administration, indicated for gastric constipation, term therapy.
suspension (2 dosage, ulcers in adults. and dizziness
mg/mL) contraindications, -Omeprazole is are also
interactions, and indicated for reported in 1 to
potential adverse gastroesophageal 2 % of patients.
effects of reflux disease in The major
omeprazole pediatric and adult adverse effects
therapy. It also populations. in the pediatric
highlights other -Omeprazole is also population are
key elements of indicated for healing similar to adults;
omeprazole erosive esophagitis in the most
therapy in the both adults and frequent events
clinical setting as it children. were reportedly
relates to the -Omeprazole is fever and
essential points indicated for conditions respiratory
needed by prone to infections.
members of an hypersecretion, such Proton pump
interprofessional as Zollinger-Ellison inhibitors (PPI)
team managing syndrome, multiple therapy may
the care of patients endocrine adenomas, correlate with an
with peptic ulcers and systemic increased risk
and other related mastocytosis in adults. of Clostridioides
conditions and Uncomplicated difficile (C. diff)
sequelae. heartburn (OTC use) associated
diarrhea.
There are rare
reports of
hypomagnesemi
a with prolonged
treatment with
PPIs.
Avoid
concomitant use
of omeprazole
with St John’s
wort or rifampin
and other
CYP450
inducers due to
the potential
reduction in
omeprazole
concentration.
There is an
increased risk of
drug resistance
or toxic effect of
antiretroviral
medicines when
used with
omeprazole.