PHARMACOLOGY MID-SEMESTER

EXAMS 2020-21 A/B

Take your time to read the instructions and questions carefully before answering. Best
wishes!!!

INSTRUCTIONS: ATTEMPT ALL QUESTIONS

This is an automatic response quiz, so please pay attention to the following.
• ATTEMPT THE QUIZ ONLY ONCE
• This is a 40 MINUTE quiz starting from 6 pm to 6:40 pm
• Remember to enter your NAME and INDEX NUMBER CORRECTLY.
• Pay attention to the question and ensure that you provide the RIGHT ANSWERS
• Remember to click the SUBMIT button when you finish
• Failure to click the SUBMIT button would result in the exam NOT being submitted and loss
of marks.
• The submission should be done within the STIPULATED TIME for the exam.
• ANY SUBMISSION AFTER THE STIPULATED TIME ATTRACTS A PENALTY OF MINUS
TWO (2) MARKS FOR THE FIRST 1-30 MINUTES AFTER THE STIPULATED TIME AND
MINUS ONE (1) MARK FOR EVERY 30 MINUTES THEREAFTER.
* Required

The earliest evidence that a drug is stored in tissue is ____________

B. A large apparent volume of distribution (VD)
C. An increase in plasma protein binding
A. A decrease in the rate of formation of metabolites by the liver
D. An increase in the number of side effects produced by the drug

Clear selection

A prodrug is _______________
B. the oldest member of a class of drugs
D. a drug that is stored in body tissues and is then gradually released in the circulation
C. an inactive drug that is transformed in the body to an active metabolite
A. the prototype member of a class of drugs

Clear selection

The first step in the nursing process is assessment. Which of following should not
be considered during the assessment phase?
A. History of past illnesses and the current complaint
C. Socioeconomic status and psychological support
B. Plan of care
D. The patient’s drug history and present drug use
 Clear selection

The actual concentration of drug present within the plasma (bloodstream) following
administration is dependent on pharmacokinetic processes
True
False

Clear selection

Drugs are distributed to various tissues throughout the body dependent on their
solubility and ionization
True
False

Clear selection

INDEX NUMBER *

Which of the following provides information about the variation in sensitivity of the
drug within an individual studied
C. Quantal dose-response curve
D. Therapeutic index
A. Drug potency
B. Grade dose-response curve

Clear selection

High plasma protein binding _______________

A. facilitates glomerular filtration of the drug
C. increases the volume of distribution of the drug
B. generally, makes the drug long acting
D. minimizes drug interactions

Clear selection

Alcohol in combination with other irritants such as indomethacin may increase the
chance of gastrointestinal bleed
True
False

Clear selection

The Food and Drug Administration (FDA) pregnancy categories

B. are used for research purposes only.
C. indicate a drug’s potential or actual teratogenic effects.
D. list drugs that are more likely to have addicting properties.
A. are tightly regulated by the standards authority

Clear selection

The half-life of a drug is not affected by all aspects of pharmacokinetics

True
False

Clear selection

Which tissue has the greatest capacity to bio-transform drugs?

B. Kidney
A. Brain
C. Liver
D. Lung

Clear selection

When assessing a patient’s need for medications and choosing the best medication
for the patient, the healthcare provider must consider which of the following issues
(select all that apply) (2 marks)
Choose the appropriate therapy/treatment based on current practice and evidence-based
research
absorption, distribution, metabolism, and excretion of drug.
Define the patient’s problem for which treatment is indicated.
the condition for which the patient is to be treated.
Provide information to the patient and caregivers about the drug, instructions for use, and any
precautions
Verify the suitability of the chosen treatment.

NAME *

The loading dose of a drug is usually based on the ______________

B. Area under the plasma drug concentration versus time curve
D. Percentage of drug bound to plasma proteins
A. Apparent volume of distribution (VD) and desired drug concentration in plasma
C. Fraction of drug excreted unchanged in the urine

Clear selection

Which of the following terms best describes a drug that blocks the action of
epinephrine at its receptors by occupying those receptors without activating them?
B. Partial agonist
A. Non-competitive antagonist
D. Physiological antagonist
C. Pharmacological antagonist

Clear selection
Prescribing in pregnancy is a balance between the risk of adverse drug effects on
the foetus and the risk of leaving maternal disease untreated
True
False

Clear selection

Half-life is proportional to clearance but inversely proportional to steady-state

True
False

Clear selection

Redistribution is a feature of _____________

C. highly plasma protein bound drugs
B. highly lipid soluble drugs
A. depot preparations
D. poorly lipid soluble drugs

Clear selection

The most important factor governing absorption of a drug from intact skin is the site
of application
True
False

Clear selection

If a drug is eliminated by first order kinetics a constant amount of the drug will be
eliminated per unit time
True
False

Clear selection

Displacement of a drug from plasma protein binding sites results in a transient

increased volume of distribution (Vd)
True
False

Clear selection

Urticaria that appears rapidly after the ingestion of a drug usually indicates which
type of hypersensitivity reaction?
A. Type I
C. Type III
D. Type IV
B. Type II

Clear selection

‘Drug efficacy’ refers to the therapeutic dose range of the drug

True
False

Clear selection

Biotransformation of drugs is primarily directed to ____________

C. convert nonlipid soluble drugs into lipid soluble metabolite
B. convert lipid soluble drugs into nonlipid soluble metabolites
A. activate the drug
D. inactivate the drug

Clear selection

PROGRAMME/LEVEL *
NURSING/MIDWIFERY L200
DIPLOMA MLT L200
CODEL MIDWIFERY L300
DEGREE MLT L200

The route of drug administration that gives the most rapid onset of the
pharmacological effect is ________________
B. intravenous route
C. intradermal route
A. intramuscular route
D. subcutaneous route

Clear selection

Alcohol can be combined with Metronidazole because alcohol does not interact
with metronidazole
True
False

Clear selection

Active transport differs from facilitated transport in following ways, except

________
A. carrier is involved
B. energy is required
C. it is against concentration gradient
D. all of the above

Clear selection
The intensity of the pharmacologic action of a drug is most dependent on the
elimination half-life (t½ ) of the drug
True
False

Clear selection

When therapeutic effects decline both below and above a narrow range of doses, a
drug is said to exhibit ceiling effect
True
False

Clear selection

Induction of drug metabolizing enzymes involves increased synthesis of enzyme

protein
True
False

Clear selection

Submit
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PHARMACOLOGY MID-SEMESTER
EXAMS 2020-21 A/B
Take your time to read the instructions and questions carefully before answering. Best
wishes!!!

INSTRUCTIONS: ATTEMPT ALL QUESTIONS

This is an automatic response quiz, so please pay attention to the following.
• ATTEMPT THE QUIZ ONLY ONCE
• This is a 40 MINUTE quiz starting from 6 pm to 6:40 pm
• Remember to enter your NAME and INDEX NUMBER CORRECTLY.
• Pay attention to the question and ensure that you provide the RIGHT ANSWERS
• Remember to click the SUBMIT button when you finish
• Failure to click the SUBMIT button would result in the exam NOT being submitted and loss
of marks.
• The submission should be done within the STIPULATED TIME for the exam.
• ANY SUBMISSION AFTER THE STIPULATED TIME ATTRACTS A PENALTY OF MINUS
TWO (2) MARKS FOR THE FIRST 1-30 MINUTES AFTER THE STIPULATED TIME AND
MINUS ONE (1) MARK FOR EVERY 30 MINUTES THEREAFTER.

The earliest evidence that a drug is stored in tissue is ____________

B. A large apparent volume of distribution (VD)
C. An increase in plasma protein binding
A. A decrease in the rate of formation of metabolites by the liver
D. An increase in the number of side effects produced by the drug

A prodrug is _______________
B. the oldest member of a class of drugs
D. a drug that is stored in body tissues and is then gradually released in the circulation
C. an inactive drug that is transformed in the body to an active metabolite
A. the prototype member of a class of drugs

The first step in the nursing process is assessment. Which of following should not
be considered during the assessment phase?
A. History of past illnesses and the current complaint
C. Socioeconomic status and psychological support
B. Plan of care
D. The patient’s drug history and present drug use

The actual concentration of drug present within the plasma (bloodstream) following
administration is dependent on pharmacokinetic processes
True
False
Drugs are distributed to various tissues throughout the body dependent on their
solubility and ionization
True
False

INDEX NUMBER *
032312220

Which of the following provides information about the variation in sensitivity of the
drug within an individual studied
C. Quantal dose-response curve
D. Therapeutic index
A. Drug potency
B. Grade dose-response curve

High plasma protein binding _______________

A. facilitates glomerular filtration of the drug
C. increases the volume of distribution of the drug
B. generally, makes the drug long acting
D. minimizes drug interactions

Alcohol in combination with other irritants such as indomethacin may increase the
chance of gastrointestinal bleed
True
False

The Food and Drug Administration (FDA) pregnancy categories

B. are used for research purposes only.
C. indicate a drug’s potential or actual teratogenic effects.
D. list drugs that are more likely to have addicting properties.
A. are tightly regulated by the standards authority

The half-life of a drug is not affected by all aspects of pharmacokinetics

True
False

Which tissue has the greatest capacity to bio-transform drugs?

B. Kidney
A. Brain
C. Liver
D. Lung

When assessing a patient’s need for medications and choosing the best medication
for the patient, the healthcare provider must consider which of the following issues
(select all that apply) (2 marks)
Choose the appropriate therapy/treatment based on current practice and evidence-based
research
absorption, distribution, metabolism, and excretion of drug.
Define the patient’s problem for which treatment is indicated.
the condition for which the patient is to be treated.
Provide information to the patient and caregivers about the drug, instructions for use, and any
precautions
Verify the suitability of the chosen treatment.

NAME *
bernice gyasi

The loading dose of a drug is usually based on the ______________

B. Area under the plasma drug concentration versus time curve
D. Percentage of drug bound to plasma proteins
A. Apparent volume of distribution (VD) and desired drug concentration in plasma
C. Fraction of drug excreted unchanged in the urine

Which of the following terms best describes a drug that blocks the action of
epinephrine at its receptors by occupying those receptors without activating them?
B. Partial agonist
A. Non-competitive antagonist
D. Physiological antagonist
C. Pharmacological antagonist

Prescribing in pregnancy is a balance between the risk of adverse drug effects on

the foetus and the risk of leaving maternal disease untreated
True
False

Half-life is proportional to clearance but inversely proportional to steady-state

True
False

Redistribution is a feature of _____________

C. highly plasma protein bound drugs
B. highly lipid soluble drugs
A. depot preparations
D. poorly lipid soluble drugs

The most important factor governing absorption of a drug from intact skin is the site
of application
True
False

If a drug is eliminated by first order kinetics a constant amount of the drug will be
eliminated per unit time
True
False
Displacement of a drug from plasma protein binding sites results in a transient
increased volume of distribution (Vd)
True
False

Urticaria that appears rapidly after the ingestion of a drug usually indicates which
type of hypersensitivity reaction?
A. Type I
C. Type III
D. Type IV
B. Type II

‘Drug efficacy’ refers to the therapeutic dose range of the drug

True
False

Biotransformation of drugs is primarily directed to ____________

C. convert nonlipid soluble drugs into lipid soluble metabolite
B. convert lipid soluble drugs into nonlipid soluble metabolites
A. activate the drug
D. inactivate the drug

PROGRAMME/LEVEL *
NURSING/MIDWIFERY L200
DIPLOMA MLT L200
CODEL MIDWIFERY L300
DEGREE MLT L200

The route of drug administration that gives the most rapid onset of the
pharmacological effect is ________________
B. intravenous route
C. intradermal route
A. intramuscular route
D. subcutaneous route

Alcohol can be combined with Metronidazole because alcohol does not interact
with metronidazole
True
False

Active transport differs from facilitated transport in following ways, except

________
A. carrier is involved
B. energy is required
C. it is against concentration gradient
D. all of the above
The intensity of the pharmacologic action of a drug is most dependent on the
elimination half-life (t½ ) of the drug
True
False

When therapeutic effects decline both below and above a narrow range of doses, a
drug is said to exhibit ceiling effect
True
False

Induction of drug metabolizing enzymes involves increased synthesis of enzyme

protein
True
False
This form was created inside of Garden City University College.

 Forms