WOLLEGA UNIVERSIY

Institution of Health Science

Pharmacology exam for post basic midwifery and neonatal nursing students
Total mark: 20% Time allowed: 30 min
Name _______________________________________ Id No ______________

PART I: Choose the best answer from the given alternatives (1pt each).

1. Mr Abdi, 25 years old medical student, is given a prescription for Heart failure that physician
states very narrow therapeutic index. Which of the statements best describe the drug as it relate
to therapeutic index?
A. The drug’s serum levels will not likely need to be carefully monitored
B. The drug is likely to cross the blood-brain barrier
C. The drug is likely to have extensive drug-drug interaction
D. The drug is likely to have a serious adverse effects in case of slight dose increase
2. Incorrect about intravascular routes drug administration
A. Used more often in life threatening situation
B. Rapid onset of action
C. Entire administered dose is available to general circulation
D. They have absorption phase E. All
3. Which one of the following drug is sourced from animal product?
A. Heparin B. Aspirin C. Atropine D. Streptomycin
4. Which one of the following drug is Ideal?
A. Ceftriaxone B. Digoxin C. Ibuprofen D. All E. None
5. True statement about drug absorption
A. It a process by which drug leaves the bloodstream
B. The absorption of acidic drugs in acidic medium is low
C. Ionized drugs can easily cross the cell membrane
D. Fatty food increases absorption of fat soluble drugs
6. Which one of the following statement is false?
A. Potency is the amount of drug we must give to elicit an effect
B. Efficacy is the largest effect that a drug can produce
C. Affinity is the ability of a drug to bind a receptor
D. Intrinsic activity is the capacity of drug to produce response/effect
E. None
7. What does “pharmacokinetics” include?
A. Pharmacological effect of drugs C. Chemical structure of medical agents
B. Unwanted effects of drugs D. Distribution of drugs in the body
8. Pharmacodynamics involves the study of following, except.
A. Biological and therapeutic effects of drugs C. Mechanisms of drug action
B. Absorption and distribution of drugs D. Drug interactions
9. The fraction of the administered drug that reaches systemic circulation is:
A. Volume of distribution B. Clearance C. Bioavailability D. Half-life
10. A drug that binds to and blocks the activation of receptors by indigenous or exogenous agonists:
A. Agonist B. Antagonist C. Inverse agonist D. Partial agonist
11. Which of the following statement describes the first pass effect?
A. Inactivation of drug as a result of the gastric acid
B. Absorption of drugs through the duodenum
C. Drug given orally is metabolized by the liver before entering the circulation
D. Drug given IV accumulates quickly in the central nervous system(CNS)

12. One is internationally unified name of drug and also considered as non-property name.
A. Generic name B. Brand name C. Chemical name D. All
13. From the following drug one is derived from microorganism.
A. Aspirin B. Insulin C. Morphine D. Penicillin
14. Which of the following processes proceeds in the second phase of biotransformation?
A. Acetylation B. Reduction C. Oxidation D. Hydrolysis
15. Which of the following drug is enzyme inhibitor?
B. Phenytoin B. Rifampicin C. Cimetidine D. Nevirapine
16. Which one indicates ability of a drug to bind a receptor?
A. Affinity B. Intrinsic activity C. Agonist D. Antagonist
17. --------- is the process by which a drug reversibly leaves the blood stream and reaches the
intracellular sites.
A. Absorption B. Distribution C. Metabolism D. Excretion

Part II: Write short and precise answer for the following question.

1. Explain Drug metabolism and factors affecting metabolism of drug in detail. (3pt)