Index 743 Fluidized bed coating 133, Fluidized bed granulation method 112 Forced:-convection type oven 486 components of dry heat sterlizer 486 Formulation considerations of suspensions 273 Formulation considerations 540 physiological parameters 540 calculation of mosmoles/itre 540 relation between osmolarity and tonicity 540 Formulation considerations for ‘ophthalmic products 565 Formulation considerations of creams 224 ‘texture and smoothness 224 surfactants in creams 224 Consistency of creams 225 rheological and elastic properties of creams 225 droplet size 226 Formulation development 690 Formulation excipionts 283 criteria of selection of suitable excipients 284 ‘types of excipients used in suspension 284 dispersing agents 284 typesof dispersing agents 284 wetting agents 285 deflocculating agents 285 protective colloids 286 ‘gold number 286 electrotytes 286 suspending agents 287 categories of hydrocolloids 287 cellulose derivatives 287 polysaccharides and gums 288 xanthan gum 288 synthetic polymers 288 carbomers 288 clays 289 Formulation excipients 391 viscosity enhancer 392 buffers 391 preservatives for solution preparation 392 ‘microbial death kinetics 393, concentration exponents of preservatives 393, factors influencing the activity of a preservative 393 density modifiers 394 isotonicity modifiers 394 antioxidants in solution Preparations 395 sweetening agents 395 aspartame 396. saccharin 396 cyclamate 396 Formulation parameters of solution dosage forms 371 solubility 371 solubilization 375 methods of solubilization 375 pH 376 dissociation of drug 376 buffers for solution dosage forms 378 casolvent 379 dielectric constant 380 surface active agents 380 solubilizing excipients 381 complexing agents 381 hydrotrophy 384 chemical modification of drug 384 particle sie reduction 385 Friablity 137 Funetions of packaging 602 protective function 602 Fusion method of preparation of ointment 236 G Gamma radiation 498 Glass components 474 deposition of flakes or precipitates 475 Glidants 87 efficiency ofthe giant 88 colloidal silica 88 talcum 69 Granulation 70 characterization of granules 72 volume shape factor 71 surface shape factor 72 shape coefcient 72 morphological descriptors 73 granule density 73 porosity of granules 74 Guar gum 80 ion exchange resin 91. super lsintegrants 91 sodium starch aycoate 81 croscarmellse sodium $1 crospovidones 81 soya polysaccharide 92 croselinked alginic acid 92 selon gum 92 xanthan gum 92 high shear granulation 92 H Hardness 137 Humectants and cosolvents 290 ICH guidelines 704 identification tests 138 Intrnsiclubrication 109 in-process quality control 196 Instability of cream 229 reversal of phase 229, creaming 229 settingin cream 229 phases of creaming and sedimentation 230 Interaction between plastic and product 625 permeation 625 leaching 626 sorption 626 change in physicochemical properties 627