Agilent InfinityLab LC Series

SELECTION GUIDE
AGILENT INFINITYLAB LC SERIES

EFFICIENT LC SOLUTIONS –
FOR ANY APPLICATION AND BUDGET

The Agilent InfinityLab LC Series offers you an unmatched choice of instrumentation for liquid
chromatography. Use this product selection guide to identify which configuration fits best to your
laboratory’s requirements.

Analytical LC Systems
From routine analysis to cutting-edge research, the Agilent InfinityLab LC Series offers the broadest portfolio of liquid
chromatography solutions, helping you to achieve highest operational efficiency while keeping within your budget.

NEW

Agilent 1220 Agilent 1260 Agilent 1260 Agilent 1290

Infinity II LC –
Affordable efficiency
The 1220 Infinity II LC is
an affordable, high-quality,
integrated system that
puts you on the fast track
to highest efficiency – for
maximum return on investment.
Infinity II LC –
Everyday efficiency
The 1260 Infinity II LC is the
trusted platform with the broadest
choice of instrumentation, giving
you the best operational
efficiency to take you to the
next level of confidence –
every day in every way.
Infinity II Prime LC –
Everyday efficiency
with more convenience
The Agilent 1260 Infinity II
Prime LC is the most convenient
LC within the 1260 Infinity II LC
portfolio. It offers the highest
ease-of-use and functionality
for everyday analysis.
Infinity II LC –
The benchmark
in efficiency
The 1290 Infinity II LC embodies
the next generation of liquid
chromatography instrumentation,
setting the benchmark in ultrahigh
performance to deliver the
maximum in efficiency.

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InfinityLab LC Workflow Solutions
The flexibility of the InfinityLab LC Series allows Agilent to offer the broadest portfolio of liquid chromatography solutions.
From LC method development to GPC/SEC and SFC, and from online SPE to 2D-LC, the InfinityLab LC Series gives you
infinite possibilities to solve your separation challenges.

InfinityLab GPC/SEC Solutions InfinityLab

Characterize polymers and Impurity Analysis Solutions
biomolecules to give accurate Detect and quantify all components in your
molecular weights, distributions, sample – in a single run – using the high-
and structural detail regarding dynamic range feature that delivers a 30x
particle shape and size in solution. wider range, and 30x higher sensitivity.

InfinityLab InfinityLab LC
Online SPE Solutions Method Development Solutions
Enrich analytes, remove matrix Accelerate your method development with
components or lower detection dedicated hardware and software. Utilize up
limits with tailored solutions to match to 26 solvents and 32 columns to create more
virtually any analytical LC challenge. than 1000 different sets of LC conditions.

InfinityLab SFC Solutions InfinityLab Bio-Inert LC Solutions

Achieve superior resolution of Corrosion-resistant and biologically-inert
stereoisomers through supercritical flow path protects your biomolecules
fluid chromatography with standard- and your instruments – for bio-analysis,
grade CO2. Lower solvent waste and biopurification, and nonbiological
cut purchase and disposal costs. applications requiring an inert flow path.

InfinityLab 2D-LC Solutions InfinityLab LC Method Transfer Solutions

Switch easily between Execute any conventional LC or latest
one-dimensional ultrahigh- UHPLC method while achieving the same
performance LC and the ultimate chromatographic results. Transfer methods
chromatographic power of heart- seamlessly between Agilent and other
cutting, multiple heart-cutting LC systems with Intelligent System
and comprehensive 2D-LC. Emulation Technology (ISET).

For details of Agilent InfinityLab LC Purification Solutions, see our Selection Guide, publication number 5991-8010EN. 3
AGILENT INFINITYLAB LC SERIES

CONFIGURE YOUR LC SYSTEM

Instrument Control
InfinityLab LC Companion Handheld instrument controller for 1260 and 1290 Infinity II LCs G7108AA

Solvent Preparation
1260 Infinity II Degasser 4 channels; up to 10 mL/min flow; 12 mL internal volume per channel G7122A

Solvent Delivery
1290 Infinity II High Speed Pump 1300 bar up to 2 mL/min, ramping down to 800 bar at 5 mL/min; binary solvent mixing; integrated G7120A
degassing unit

1290 Infinity II Flexible Pump 1300 bar up to 2 mL/min, ramping down to 800 bar at 5 mL/min; quaternary solvent mixing; G7104A
integrated degassing unit

1260 Infinity II Flexible Pump 800 bar up to 5 mL/min; quaternary solvent mixing; integrated degassing unit G7104C

1260 Infinity II Binary Pump 600 bar up to 5 mL/min; integrated degassing unit; optional SSV G7112B

1260 Infinity II Quaternary Pump 600 bar up to 5 mL/min; 200 bar up to 10 mL/min; integrated degassing unit G7111B

1260 Infinity II Bio-Inert Pump 600 bar up to 5 mL/min; 200 bar up to 10 mL/min; integrated degassing unit; quaternary mixing; G5654A
all materials in flow path inert

1260 Infinity II Isocratic Pump 600 bar up to 5 mL/min; 200 bar up to 10 mL/min; optional integrated degassing unit and SSV G7110B

1260 Infinity II SFC Binary Pump Delivers supercritical CO2 and modifiers at up to 600 bar and 5 mL/min; binary solvent mixing; G4782A
integrated degassing unit and two-solvent selection valve for channel B

1260 Infinity Capillary Pump1 Up to 20 μL/min; up to 100 µL/min with extended flow range kit; 400 bar; 0.18 to 1.0 mm column id G1376A

1260 Infinity Nanoflow Pump1 Up to 4 μL/min; 400 bar; 0.075 to 0.1 mm column id G2226A

LC Support Modules
1260 Infinity II SFC Control Module Compresses CO2 and houses backpressure regulator; uses liquefied (analytical grade) or gaseous CO2 G4301A
(beverage grade); low dispersion nozzle for full flow transfer to MS or ELSD

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 Valve Solutions
1290 Infinity Flexible Cube For enhanced injection modes and advanced valve-switching applications such as online SPE G4227A

1290 Infinity Valve Drive Drive unit for any InfinityLab Quick Change valve head G1170A

InfinityLab Quick Change Valves Available in stainless-steel for high-pressure and ultrahigh-pressure applications up Get product
to 1300 bar as well as with bio-inert materials in flow paths for bio-chromatographic numbers2
applications

Sample Injection
1290 Infinity II Multisampler 0 to 20 μL or 0 to 100 μL single-stroke injection at 1300 bar; up to 1500 μL with optional G7167B
kits; sample capacity up to 432 vials and up to 16 microtiter plates; multiwash option
for less than 9 ppm carryover; optional sample cooling (Option 100) or thermostatting
(Option 101) available; dual-needle option for highest throughput and flexibility

1290 Infinity II Vialsampler 0.1 to 20 μL (40 optionally); up to 120 µL with multi-draw mode at 1300 bar; G7129B
sample capacity up to 132 x 2 mL vials; optional integrated column compartment for
column heating up to 80 °C; optional sample cooling (Option 100) or thermostatting
(Option 101) available

1260 Infinity II Multisampler 0 to 100 μL single-stroke injection at 800 bar; up to 1800 μL with optional kits; sample G7167A
capacity up to 432 vials and up to 16 microtiter plates; multi-wash option for less than
9 ppm carryover; optional sample cooling (Option 100) or thermostatting (Option 101)
available; dual-needle option for highest throughput and flexibility

1260 Infinity II Vialsampler 0.1 to 100 μL injection from vials at up to 800 bar; up to 1500 µL with optional kits; G7129C
optional integrated column compartment for column heating up to 80 °C; optional
sample cooling (Option 100) or thermostatting (Option 101) available

1260 Infinity II Vialsampler 0.1 to 100 μL injection from vials at up to 600 bar; up to 1800 µL with optional kits; G7129A
optional integrated column compartment for column heating up to 80 °C; optional
sample cooling (Option 100) or thermostatting (Option 101) available

1260 Infinity II Bio-Inert Multisampler 0 to 100 μL single-stroke injection at 600 bar; up to 1000 µL with optional kits; sample G5668A
capacity up to 432 vials and up to 16 plates; multi-wash option for less than 9 ppm
carryover; optional sample cooling (Option 100) or thermostatting (Option 101)
available; all materials in flow path inert

1260 Infinity II SFC Multisampler
Operates in SFC or LC mode; in SFC mode, injection is done through Feed Injection G4767A
principle that enables highly reproducible injection with injection volumes from
0.1 to 90 μL at up to 600 bar; in LC mode, injection is done through classic flow-through
principle; sample capacity up to 432 vials and up to 16 microtiter plates; optional
sample cooling (Option 100) or thermostatting (Option 101) available

1260 Infinity High-Performance 0.01 to 8 μL injection from vials and microtiter plates G1377A
Micro Autosampler1

1260 Infinity II Manual Injector 5 μL to 20 mL injection loops G1328C

1260 Infinity II Bio-Inert Manual Injector 5 μL to 20 mL injection loops G5628A

1
Check with Agilent for availability in your country.  2
Visit www.agilent.com/chem/lc-valve-solutions for product numbers. 5
 Column Compartments
1290 Infinity II Multicolumn Thermostat
1260 Infinity II Multicolumn Thermostat
UV Detection
1290 Infinity II Diode Array Detector
1290 Infinity II Diode Array Detector FS
1290 Infinity II Variable Wavelength Detector
1260 Infinity II Diode Array Detector HS
1260 Infinity II Diode Array Detector WR
1260 Infinity II Multiple Wavelength Detector
1260 Infinity II Variable Wavelength Detector
Special Detection
1290 Infinity II Evaporative Light
Scattering Detector
1260 Infinity II Evaporative Light
Scattering Detector
1260 Infinity II Fluorescence
Detector Spectra
1260 Infinity II Fluorescence Detector
1290 Infinity II Refractive Index Detector
1260 Infinity II Refractive Index Detector
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20 degrees below ambient to 110 °C; up to four 30 cm columns and up to eight 10 cm G7116B
columns; up to eight individual InfinityLab Quick Connect heat exchangers for standard-
flow, high-flow and ultralow dispersion; optional valve drive for InfinityLab Quick
Change valve heads
10 degrees below ambient to 85 °C; up to four 30 cm columns; up to four individual G7116A
InfinityLab Quick Connect heat exchangers; optional valve drive for InfinityLab Quick
Change valve heads (up to 800 bar and up to 4-column selection without replumbing)
± 0.6 μAU/cm noise (60 mm Max-Light cartridge cell) or ± 3 μAU/cm noise G7117B
(10 mm Max-Light cell); 240 Hz; spectra; 8 signals; 1 to 8 nm slit; 190 to 640 nm
± 0.6 μAU/cm noise (60 mm Max-Light cartridge cell) or ± 3 μAU/cm noise G7117A
(10 mm Max-Light cell); 120 Hz; spectra; 8 signals; fixed slit; 190 to 640 nm
± 1.5 μAU noise; time-programmable, 240 Hz (single wavelength detection); G7114B
2.5 Hz (dual wavelength detection); 190 to 600 nm
± 0.6 μAU/cm noise (60 mm Max-Light cell) or ± 3 μAU/cm noise G7117C
(10 mm Max-Light cell); 120 Hz; spectra; 8 signals; fixed slit; 190 to 640 nm
± 7 μAU/cm noise; 120 Hz; spectra; 8 signals; 190 to 950 nm G7115A
± 7 μAU/cm noise; 120 Hz; 8 signals; 190 to 950 nm G7165A
± 2.5 μAU/cm noise; 120 Hz (single wavelength detection); G7114A
2.5 Hz (dual wavelength detection); 190 to 600 nm
For subambient operation; flow range 0.2 to 5 mL/min; evaporator temperature G7102A
10 to 80 °C; nebulizer temperature 25 to 90 °C
For subambient operation; flow range 0.2 to 5 mL/min; evaporator temperature G4260B
25 to 120 °C; nebulizer temperature 25 to 90 °C
Multisignal fluorescence detector; online spectra; 4 signals; 148 Hz; 4000 h lamp; G7121B
Raman (H2O) > 500 (noise reference measured at signal); Raman (H2O) > 3000
(noise reference measured at dark value)
One signal wavelength, 74 Hz; 4000 h lamp; Raman (H2O) > 500 (noise reference G7121A
measured at signal); Raman (H2O) > 3000 (noise reference measured at dark value)
148 Hz; 1.00 to 1.75 RI range; ±600 x10-6 RIU measurement range; G7162B
Noise < ±2.5 x10-9 RIU; < 1 h warm-up; 5 degrees above ambient up to 55 °C
74 Hz; 1.00 to 1.75 RI range; ±600 x10-6 RIU measurement range; G7162A
Noise < ±2.5 x10-9 RIU; < 1 h warm-up; 5 degrees above ambient up to 55 °C
Fraction Collection
1290 Infinity Thermostat
1260 Infinity II Analytical-Scale Fraction Collector Up to 10 mL/min flow
1260 Infinity II Bio-Inert Analytical-Scale
Fraction Collector
GPC/SEC Systems
1260 Infinity II GPC Multi-Detector System
1260 Infinity II GPC/SEC MDS
Refractive Index Detector
1260 Infinity II GPC/SEC MDS Viscometer
1260 Infinity II GPC/SEC MDS Dual-Angle
Light Scattering Detector
1260 Infinity II High-Temperature GPC System
1260 Infinity II High-Temperature Viscometer
1260 Infinity II High-Temperature
Light Scattering Detector
1260 Infinity II High-Temperature
Evaporative Light Scattering Detector
SP260VS Sample Preparation System
Integrated LC Systems
1220 Infinity II Gradient LC
1220 Infinity II Gradient LC
1220 Infinity II Gradient LC
1220 Infinity II Isocratic LC
4 to 40 °C (for all fraction collectors) G1330B
G1364F
Up to 10 mL/min flow; all materials in flow path inert G5664B
Single or dual-enclosure system; accommodates any combination of refractive index G7800A
detector, viscometer, and light scattering detector
660 nm light source; 6 μL cell volume; linearity 250 μRIU; short-term noise < 20 nRIU G7801A
(< 80 μV); pressure rating 350 kPa (50 psi); temperature range 30 to 60 °C;
temperature stability ± 0.2 °C; sensitivity 4 mV/μRIU
Linearity 0.5 % FS; shear rate (typical) 3000 s-1; sensitivity ηsp 1 x 10-5 Pa.s; temperature G7802A
range 30 to 60 °C, temperature stability ± 0.2 °C
Sample cell volume 10 μL; light scattering volume 0.01 μL; laser wavelength/ G7803A
power 660 nm/50 mW; Rayleigh scattering angles 15° and 90°; temperature range
30 to 60 °C; temperature stability ± 0.2 °C
Pump flow range 0.1 to 10.0 mL/min; reproducibility ≤ 0.07 %; oven capacity up to G7820B
six 6 x 300 mm GPC columns; temperature range ambient to 220 °C; temperature
stability < 0.05 °C/h; RID flow cell volume 8 µL; sensitivity 2.5 x 10-7 RIU/mV;
noise ≤ 80 µV; wavelength 890 nm; drift ≤ 10 mV/h; autosampler capacity 40 x 2 mL
vials; integrated 6-port/2-position valve; flushed fixed loop 5 to 500 μL
Linearity 0.5 % FS; shear rate (typical) 3000 s-1; sensitivity ηsp 1 x 10-5 Pa.s G7821B
Sample cell volume 10 μL; light scattering volume 0.01 μL; laser wavelength/power G7822B
680 nm/30 mW; Rayleigh scattering angles 15° and 90°
Evaporator temperature range 25 to 120 °C; nebulizer and transfer line 25 to 160 °C; G7826A
short-term noise < 0.2 mV; drift < 1 mV/h; LED light source (480 nm); PMT detection
with digital signal processing; flow rate range 0.5 to 5.0 mL/min; gas flow 0.2 to 0.5 SLM
Temperature range ambient to 260 °C; temperature accuracy ± 2 °C; sample G7823A
capacity 20, minimum 2 mL, maximum 20 mL; filtration 0.5 or 2 µm frit; agitation by
horizontal motion with variable speed control
Binary gradient solvent pump, autosampler, column oven and diode array detector G4294B
Binary gradient solvent pump, autosampler, column oven and variable G4290B
wavelength detector
Binary gradient solvent pump, manual injector and variable wavelength detector G4288B
Single solvent pump, manual injector and variable wavelength detector G4286B
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Learn more
www.agilent.com/chem/infinitylab-lc-series

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This information is subject to change without notice.

© Agilent Technologies, Inc. 2017

Published in the USA, September 1, 2017
5991-8252EN