SSRI: increase serotonin levels in central nervous system (CNS) by inhibiting their presynaptic reuptake (Increases serotonin in the

synapse )
*Higher doses needed for OCD, eating disorders and PTSD
*start low doses for panic disorders
Generic Name Trade Name Indications Dosage forms
Citalopram Celexa -MDD Tabs/caps: 10, 20, 30, 40 mg
-binge eating Oral: 10mg/5 mL
-not recommended to increase dose until steady state has been reached 1-2 weeks
-causes QT prolongation- do NOT dose higher than 40mg/day OR 20mg/day in patients 65 and older
-cases of galactorrhea, breast enlargement and gynecomastia
-do not mix with antifungals = serotonin syndrome
Escitalopram Lexapro -MDD Tabs/caps: 5, 10, 20 mg
-GAD Oral: 5 mg/ 5 mL
-OCS
-causes QT prolongation
Fluoxetine Prozac -bulimia Caps; 10, 20, 40 mg
-OCD Tabs: 10,15,20, 60 mg
-panic Oral: 20mg/ 5 ml
-pervasive Weekly: 90mg
development (ASD)
-phantom limb pain
-Raynaud’s
-Fibrositis
-fibromyalgia
-Trichotillomania,
Excoriation disorder
-schizo- neg s&s
-approved to children
with depression/OCD
-not recommended to increase dose until steady state has been reached 4 weeks
-at 20mg/day may be changed to Prozac weekly 90mg/week after 7 days after the last dose
-may need once weekly doses in treatment of panic disorder
-increases plasma level of benzo
-increased levels of valoproate
-longest half-life
-slowing of sinus node
-elevated prolactin noted
Fluvoaxamine Luvox -OCD (pedi) Tabs: 25, 50, 100 mg
-binge eating ER: 100, 150 mg
-TD (may)
-Do not use with alosetron. Also increases level of benzo and buspirone
Paroxetine Paxil -OCD Tabs: 10, 30, 40 mg
hydrochloride -panic Oral: 10 mg/ 5 ml
-social anx CR: 12.5, 25, 37.5 mg
-PTSD
-premenstrual
-GAD
-vasomotor symps of
menopause
*intermittent doses (during luteal phase) for treatment of premenstrual
*7.5 mg at bedtime for treatment of vasomotor
-increased LDL cholesterol levels
-cases of galactorrhea, breast enlargement and gynecomastia
-more likely to cause sex dysfunction
-more likely to cause sweating
-more frequent discontinuation syndrome
Sertaline Zoloft -bulimia Caps/Tabs: 25, 50, 100, 150, 200 mg
-OCD (pedi) Oral: 20 mg/ml
-panic
-social anx
-PTSD
-premenstrual
-phantom limb pain
-increased LDL cholesterol levels