Critical Care >Hematologic Dysfunction in the ICU

John M. Oropello, Stephen M. Pastores, Vladimir Kvetan+

Table 32–6Antiplatelet agents.

Half-life Mechanism

Aspirin 3h Irreversible inhibition of COX-2, decreased thromboxane synthesis

NSAIDs (eg, ibuprofen) 1.8-2 h Reversible COX-2 inhibition

Clopidogrel 7-8 h ADP P2Y12 receptor inhibitor

Prasugrel 7-8 h ADP P2Y12 receptor inhibitor

Ticlopidine 12 h ADP P2Y12 receptor inhibitor

Ticagrelor 7-8 h ADP P2Y12 receptor inhibitor

Abciximab 10-30 min GP IIb-IIIa inhibitor

Tirofiban 2h GP IIb-IIIa inhibitor

Eptifibatide 2.5 h GP IIb-IIIa inhibitor

Irreversible COX-2 inhibitor &thromboxane receptor inhibitor,

Aggrenox (aspirin and dipyridamole) 3h
Vasodilator

Voraxapar 5-13 days PAR-1 inhibitor

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