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Records identified through the Records identified through the Records identified through the

database Pubmed without applying database BVS without applying filters database scopus without applying
filters (n=589) (n=352) filters (n=749)
Identification

Records identified through database searching (n=1690)

Records identified through the Records identified through the Records identified through the
database Pubmed with filters (n=4) database BVS with filters (n=13) database SCOPUS with filters (n=11)
Screening

Records identified through database searching (n=28) Duplicated record removed


(n=9)

N° of records after duplicates removed


Eligibility

(n=19)

n° full-text articles assessed for eligibility (n=19) Reports excluded:

No meta-analysis (n=11)
Included

No efficacy evaluation (n=3)

No meta-analysis graphs (n=2)

Animal studies (1)


N° studies included in the quantitative
synthesis (meta-analysis) (n=2)

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