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Science 10 Q3 Week2 MELC02 Module2 CalumpitMark
Science 10 Q3 Week2 MELC02 Module2 CalumpitMark
Department of Education
Region I
SCHOOLS DIVISION OF ILOCOS NORTE
Science 10
Quarter 3 - Module 2:
Feedback Mechanisms Involved
in Regulating Processes in the
Female Reproductive System
Prepared by:
MARK R. CALUMPIT
Salpad Integrated School
Science- Grade 10
Share-A-Resource-Program
Quarter 3 – Module 2: Feedback Mechanisms Involved in Regulating Processes
in the Female Reproductive System
First Edition, 2020
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SCIENCE
Quarter 3 - Module 2:
Feedback Mechanisms Involved
in Regulating Processes in the
Female Reproductive System
Introductory Message
This Contextualized Learning Module (CLM) is prepared so that you, our dear
learners, can continue your studies and learn while at home. Activities, questions,
directions, exercises, and discussions are carefully stated for you to understand each
lesson with ease.
This CLM is composed of different parts. Each part shall guide you step-by-
step as you discover and understand the lesson prepared for you.
Pre-test is provided to measure your prior knowledge on the lesson. This will
show you if you need to proceed in completing this module or if you need to ask your
facilitator or your teacher’s assistance for better understanding of the lesson. At the
end of this module, you need to answer the post-test to self-check your learning.
Answer keys are provided for all activities and tests. We trust that you will be honest
in using them.
In addition to the material in the main text, Notes to the Teacher is also
provided to our facilitators and parents for strategies and reminders on how they
can best help you in your home-based learning.
Please use this module with care. Do not put unnecessary marks on any part
of this CLM. Use a separate sheet of paper in answering the exercises and tests.
Likewise, read the instructions carefully before performing each task.
If you have any question in using this CLM or any difficulty in answering the
tasks in this module, do not hesitate to consult your teacher or facilitator.
Thank you.
What I Need to Know
This module was designed and written with you in mind. It is here to help you
master the nature of Biology. The language used recognizes the diverse vocabulary
level of students. The lessons are arranged to follow the standard sequence of the
course. But the order in which you read them can be changed to correspond with the
textbook you are now using.
Objectives:
What I Know
Pre-Test
Direction: Read each statement carefully and choose the letter of the correct
answer.
Write the letter of the correct answer on a separate sheet of paper.
1. In the menstrual cycle, which hormone causes the wall of the follicle to develop
after ovulation to secrete progesterone?
A. LH
B. FSH
C. Progesterone
D. Estrogen
2. Which describe the levels of FSH and progesterone during the first 5 days of the
menstrual cycle.
A. Progesterone remains low but FSH increases
B. Progesterone and FSH both remain low
C. Progesterone increases but FSH remains low
D. Progesterone and FSH both increase
1
3. The levels of hormones vary during the menstrual cycle in women. In what
sequence do the hormones reach their maximum level, if the cycle begins at the
start of menstruation?
A. FSH, estrogen, LH, progesterone
B. FSH, LH, estrogen, progesterone
C. FSH, progesterone, LH, estrogen
D. FSH, estrogen, progesterone, LH
6. At which stage of the uterine cycle does the menstrual phase occur?
A. Days 0 to 5
B. Days 1 to 5
C. Days 5 to 14
D. Days 14 to 28
7. In a normal 28-day menstrual cycle when would you expect the LH surge to
occur?
A. Days 8 to 10
B. Days 11 to 13
C. Days 14 to 16
D. Days 17 to 19
2
9. Which hormone stimulates growth of ovarian follicles prior to ovulation?
A. FSH
B. Estrogen
C. LH
D. Progesterone
10. During the menstrual cycle, progesterone levels are at their highest during the
___________.
A. follicular phase (first part of the cycle)
B. menstruation (end of cycle)
C. luteal phase (second half of the cycle)
D. ovulation (mid-cycle)
Note: If you get 100% correct answer, you skip this module. But if you get 99
% correct answer, proceed and continue doing the activities in this module.
3
Feedback Mechanisms
Lesson Involved in Regulating
2 Processes in the Female
Reproductive System
What’s In
Activity 1. Recap!
Before We Start
Fill in the Blank. Use the words in the word banks to complete the sentences.
1. The internal reproductive organs of the female are located within the
_________, between the urinary bladder and rectum.
2. The ________ produce hormones that control the growth and release of eggs
from the ovaries.
3. While other hormones prepare the uterus so a baby can grow in it, other
hormones still control the stretching of the uterus during ______________.
4. The _________ controls the functions of both the testes and the ovaries
which keeps the reproductive system properly functioning.
5. While other hormones prepare the uterus so a baby can grow in it,
other hormones still control the stretching of the _________ during
pregnancy.
4
What’s New
Select the answer that correctly completes each sentence. Write the chosen answer
on a separate sheet of paper.
1. (Menopause, menstruation) is the process in which blood and other tissues are
shed from the uterus and leave the body through the vagina.
2. During the (luteal phase, follicular phase), the endometrium of the uterus
continues to prepare for a fertilized egg.
3. The (follicle stimulating hormone, luteinizing hormone) assists in the maturation of
the follicles and causes the secretion of estrogen from the follicles.
4. The process through which the level of one substance influences the level of
another substance is called (feedback mechanism, menopause).
5. (Estrogen, progesterone) is a hormone that promotes gestation, or the carrying of
a fetus.
What Is It
5
Figure 1. The Menstrual Cycle
https://www.edplace.com/worksheet_info/science/keystage3/year7/topic/
740/4732/reproductive-systems-and-the-menstrual-cycle
There are two key groups of hormones which control and coordinate the
menstrual cycle:
Pituitary hormones (follicle stimulating hormone and luteinizing hormone) are
released from the anterior pituitary gland and act on the ovaries to develop
follicles.
Ovarian hormones (estrogen and progesterone) are released from the ovaries
and act on the uterus to prepare for pregnancy.
The menstrual cycle (as shown in Table below) includes an ovarian and a
uterine cycle. Events in the ovarian cycle include maturation of a follicle, release of
an egg, and formation of the corpus luteum. Events in the uterine cycle include
menstruation, development of the endometrium, and thickening of the endometrium
in preparation for an egg.
6
The Phases of the Menstrual Cycle
Menstrual
Phase 1–4 Menstruation occurs
Follicular
Phase 5–13 Follicle matures and endometrium develops
Luteal Phase 15– Follicle becomes the corpus luteum and endometrium
28 prepares for an egg
The next phase of the cycle is called the follicular phase. After menstruation,
the endometrium in the uterus begins to build up again. At the same time, several
follicles start maturing in the ovaries. Only one of these maturing follicles will
complete maturation. The rest will eventually deteriorate and disappear. By the
middle of the menstrual cycle, around day 14, the remaining mature follicle releases
its oocyte from the ovary in the process of ovulation.
Following ovulation, the luteal phase begins. During the luteal phase, the
endometrium of the uterus continues to prepare for a fertilized egg. For example, it
becomes thicker and develops more blood vessels. At the same time, the mature
follicle that just released its egg develops into a structure called a corpus luteum.
The events of the menstrual cycle always occur in the same sequence, but
their timing may vary considerably. There is a great deal of normal variation in the
length of the overall cycle and of the individual phases. Variation may occur from one
female to another and also from one cycle to the next for a given female.
7
1. Follicular Phase
Follicle stimulating hormone (FSH) is secreted from the anterior pituitary
and stimulates growth of ovarian follicles.
The dominant follicle produces estrogen, which inhibits follicle stimulating
hormone (FSH) secretion (negative feedback) to prevent other follicles
growing.
Estrogen acts on the uterus to stimulate the thickening of the endometrial
layer.
2. Ovulation
Midway through the cycle (~ day 12), estrogen stimulates the anterior
pituitary to secrete hormones (positive feedback).
This positive feedback results in a large surge of luteinizing hormone (LH)
and a lesser surge of follicle stimulating hormone (FSH).
Luteinizing hormone (LH) causes the dominant follicle to rupture and
release an egg (secondary oocyte) – this is called ovulation.
3. Luteal Phase
The ruptured follicle develops into a slowly degenerating corpus luteum.
The corpus luteum secretes high levels of progesterone, as well as lower
levels of estrogen.
Estrogen and progesterone act on the uterus to thicken the endometrial
lining (in preparation for pregnancy).
Estrogen and progesterone also inhibit secretion of follicle stimulating
hormone (FSH) and luteinizing hormone (LH), preventing any follicles from
developing
4. Menstruation
If fertilization occurs, the developing embryo will implant in the
endometrium and release hormones to sustain the corpus luteum.
If fertilization doesn’t occur, the corpus luteum eventually degenerates
(forming a corpus albicans after ~ 2 weeks).
When the corpus luteum degenerates, estrogen and progesterone levels drop
and the endometrium can no longer be maintained.
The endometrial layer is sloughed away and eliminated from the body as
menstrual blood (i.e. a woman’s period).
As estrogen and progesterone levels are too now low to inhibit the anterior
pituitary, the cycle can now begin again.
Role of Hormones
The same hormones that control female puberty and oogenesis also control
the menstrual cycle: estrogen, LH, and FSH. Estrogen controls the secretion of the
two pituitary hormones by acting on the hypothalamus, which controls the pituitary
gland. This is shown in Figure below. When the estrogen level rises in the blood, it
stimulates the pituitary (via the hypothalamus) to secrete more or less luteinizing
hormone (LH) and follicle stimulating hormone (FSH).
8
Figure 2. This diagram shows how hormones control the menstrual cycle with
negative and positive feedback.
https://www.ck12.org/book/ck-12-biology-advanced-concepts/section/17.82/
During the first half of the cycle, negative feedback keeps levels of follicle
stimulating hormone (FSH), luteinizing hormone (LH), estrogen, and progesterone
relatively stable. During ovulation, positive feedback causes a burst of follicle
stimulating hormone (FSH), luteinizing hormone (LH), and estrogen. During the
second half of the cycle, progesterone rises as the corpus luteum in the ovary
matures and produces this hormone. Negative feedback helps keep levels of the other
three hormones fairly constant.
9
After the oocyte is released, luteinizing hormone (LH) stimulates the mature
follicle to develop into a corpus luteum. The corpus luteum then starts secreting
progesterone, which maintains the endometrium of the uterus. What happens next
depends on whether the egg has been fertilized or not.
If the egg has been fertilized, it will soon start producing a hormone that helps
maintain the corpus luteum. As a result, the corpus luteum will continue
producing progesterone and maintain the endometrium.
If the egg has not been fertilized, the corpus luteum will disintegrate and stop
producing progesterone. Without progesterone, the endometrium will break
down, detach from the uterus, and pass out of the body during menstruation.
Menopause
As women approach their mid-40s to mid-50s, their ovaries begin to lose their
sensitivity to follicle stimulating hormone (FSH) and luteinizing hormone (LH).
Menstrual periods become less frequent and finally cease; this is menopause. There are
still eggs and potential follicles on the ovaries, but without the stimulation of follicle
stimulating (FSH) and luteinizing hormone (LH), they will not produce a viable egg to
be released. The outcome of this is the inability to have children.
The side effects of menopause include hot flashes, heavy sweating (especially at
night), headaches, some hair loss, muscle pain, vaginal dryness, insomnia, depression,
weight gain, and mood swings. Estrogen is involved in calcium metabolism and, without
it, blood levels of calcium decrease. To replenish the blood, calcium is lost from bone
which may decrease the bone density and lead to osteoporosis. Supplementation of
estrogen in the form of hormone replacement therapy (HRT) can prevent bone loss,
but the therapy can have negative side effects. While hormone replacement therapy
10
(HRT) is thought to give some protection from colon cancer, osteoporosis, heart disease,
macular degeneration, and possibly depression, its negative side effects include
increased risk of: stroke or heart attack, blood clots, breast cancer, ovarian cancer,
endometrial cancer, gall bladder disease, and possibly dementia.
For most women in the U.S., the menstrual cycle continues into their forties.
Then it gradually becomes more and more irregular until it finally stops altogether,
generally by their early fifties. Menopause occurs when a woman has gone through
12 consecutive months without a menstrual period. She can no longer reproduce
because her ovaries no longer produce eggs.
What’s More
11
What I Have Learned
What I Can Do
Activity 5. Essay!
Question: What have you learned to avoid teen age and unwanted pregnancies?
12
Rubric for Essay
CATEGORY 4 3 2 1
Relevance of Answer is Answer is Answer is The essay did
answer to the complete; brief with incomplete. not answer
question sufficient insufficient Excessive the question.
detail detail. discussion of
provided to Unrelated unrelated
support issues were issues and/or
assertions; introduced significant
answer and/or minor errors in
focuses only errors in content.
on issues content.
related to the
question;
factually
correct.
13
Assessment
Post-Test
Direction: Read each statement carefully and choose the letter of the correct answer.
Write the letter of the correct answer on a separate sheet of paper.
1. Which of the following demonstrates positive feedback during the
menstrual cycle?
A. High levels of estrogen produce more FSH receptors on follicle cells which
allows them to produce more estrogen
B. High levels of estrogen eventually inhibit FSH
C. High levels of progesterone inhibit FSH and LH
D. High levels of LH inhibit estrogen
4. At which stage in the uterine cycle does the proliferative phase occur?
A. Days 0 to 5
B. Days 1 to 5
C. Days 5 to 14
D. Days 14 to 28
14
6. Which of the following statements about menstruation is correct?
A. During menstruation, the functional layer of the endometrium is shed,
with the basal layer remaining intact
B. Absence of menstruation always indicates an active pregnancy
C. During menstruation the entire endometrium is shed
D. During menstruation the basal layer of the endometrium is shed, with
the functional layer remaining intact
15
Additional Activities
Goal: Your objective is to present information to the public about the common and
effective contraceptive measures used in family planning, in line with the
Reproductive Health Law. The video that you will create will be in persuasive form.
The challenge is how you will be able to convince people about the benefits of various
contraceptive measures using gathered facts and scientific evidences.
Role: Assume the role of a professional video production team. You are tasked to
produce a promotional video that will used in campaign advertising about various
contraceptive measures used in family planning.
Audience: Your voice, as part of the youth, will be heard trough your campaign
advertising. You may opt to use social media advertising to let other people view your
multimedia presentation. It is important to clearly communicate your purpose from
the beginning of the video.
Standards: You will be given two (2) days to conceptualize and execute your ideas
through video-making. Once the video is finished, you may already submit it to your
teacher and you may present in social media. Your multimedia presentation will be
assessed according to the rubric given below.
16
Rubric in the Video-Making Campaign
CATEGORY 4 3 2 1
Presentation The video The video The video The video
clearly communicates indirectly dose not and
communicates some of the communicates sufficiently
the main idea, important the idea, and communicate
and is ideas, and is is hardly any idea that
strongly slightly persuasive. can persuade
persuasive. persuasive the audience.
Creativity and All the Most of the The wordings The wordings
Originality wordings and wordings and and melody and melody
melody reflect melody used were made by were not
an exceptional in the jingle the student made by the
degree of reflect but were student.
students’ students’ copied from
ingenuity in ingenuity in the ideas of
their creation. their creation. others.
Accuracy and The contents Most of the Some The contents
Relevance of the of the video contents of contents in of the video
Content are accurate the video are the video are are neither
and related to accurate and accurate and accurate nor
the topic. related to the related to the related to the
topic. topic. topic.
Required The campaign All required Few required Required
Elements advertising elements are elements are elements are
(persuasiveness, includes all included. included. missing.
musicality, required
language, etc.) elements as
well as
additional
details.
17
Answer Key
.10 C
.9 A Uterus .5
.8 D Pituitary gland .4
.7 B Pregnancy .3
.6 B Follicles .2
.5 C Pelvis .1
.4 B What’s In
.3 A
.2 A
.1 A
Pre-Test
.10 C
.9 C
.8 A
Progesterone .5 .7 D
Feedback mechanism .4 .6 A
Follicle stimulating hormone .3 .5 D
Luteal phase .2 .4 C
Menstruation .1 .3 B
What’s New .2 B
.1 A
Post-Test
18
References
Reading Materials/Links/Websites
https://www.ck12.org/book/ck-12-biology-advanced-concepts/section/17.82/
https://ib.bioninja.com.au/standard-level/topic-6-human-physiology/66-
hormones-homeostasis-and/menstrual-cycle.html
https://www.ncbi.nlm.nih.gov/books/NBK500020/
https://teachmephysiology.com/reproductive-
system/development-maturation/menstrual-cycle/
https://www.edplace.com/worksheet_info/science/keystage3/year7/topic
/ 740/4732/reproductive-systems-and-the-menstrual-cycle
19
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