The bioavailability of a drug is influenced by its physicochemical properties, formulation, and administration.

The drug and other ingredients are contained in tablets, capsules, and solutions, which can be administered
through various routes (eg, oral, buccal, sublingual, rectal, parenteral, topical, inhalational). Regardless of route,
drug absorption necessitates solution. As a result, tablets and other solids must degrade.

Unless given intravenously, drugs must pass through semipermeable cell membranes before entering the
bloodstream. Cell membranes selectively block drugs. The bimolecular lipid matrix that dominates the
membrane determines its permeability. Drugs can cross cell membranes in a variety of ways.

Passive Distribution
Improved latent-to-active transfer