INTERNSHIP PRESENTATION Name :- Sheth Jay Rajnikant

Enrollment No. :- 20BT01D079

COMPANY:-ZENTIVA PRIVATE LIMITED
• ABOUT COMPANY

• Zentiva, the European generics business of Sanofi,Is the third-largest and

one of the fastest growing Generics companies in Europe.

• Established in 1987, the Ankleshwar manufacturing site has a chemistry

and biotechnology development center, and manufactures both
intermediates and pharmaceutical formulations. A large producer of
tablets, the Ankleshwar site manufactures more than 6 billion tablets
annually.

• Zentiva is a key element of Sanofis diversification strategy, delivering

high-quality, affordable and trusted medicines to patients and
healthcare providers in more countries across all European markets.
• List of Products

• Pentoxyifylline [vasoactive drug] used to treat peripheral vascular

disease (poor circulation to the arms and legs) and intermittent
claudication (pain on walking or at rest caused by poor circulation to the
legs). It works by increasing the blood flow to the arms and legs.

• Lasamide [edema] Used to treat Furosemide is used to

reduce extra fluid in the body (edema) caused by conditions such as
heart failure, liver disease, and kidney disease.
• List of Products

• Glibenclamide [antidiabetic] used to treat type 2 diabetes mellitus in

adults. It belongs to a group of medicines called sulfonylureas and helps
control blood sugar levels in people with diabetes. This helps to prevent
serious complications of diabetes like kidney damage and blindness.

• Articaine HCL [dental anaesthesia] used for relief of pain in minor

operations, usually in combination with the vasoconstrictor epinephrine.
Drugs that block nerve conduction when applied locally to nerve tissue
in appropriate concentrations. They act on any part of the nervous
system and on every type of nerve fiber.
• EQUIPMENT & PROCESS (API1 Plant)

List Of Equipment Used in API-1:-

1) Kettle Reactor ( Glass lined kettle reactor)
2) Pressure Filter
3) Settler
4) Crystallizer
5) Centrifuge filter
6) Dreyer (Nauta Dryer)
(1) Kettle reactor(Glass lined reactor) :-

• Glass Lined reactors are primarily used for

carrying out critical chemical processes
where corrosion resistance and chemical
inertness are of critical importance.
• The metal reactor is corrosed due to
highly acidic reaction,In zentiva glass
lined reactor are used because the
reaction ocur in reactor is highly acidic.
(2) Pressure Filter:-

• A pressure filter is a closed tank with a single or a

combination of filter media for removal of one or
several contaminants.

• In filtration, pressure forces fluid and all solutes

smaller than a certain size through a membrane.

• High pressure filters are designed to withstand the

maximum pressure of the system and are sized
according to the specific flow rate required.
(3) Settler:-

• In settler heavy dense & law dense layer(aqeous layer) separated.

• Aqeous layer sent to ETP-Effluent Treatment Plant, remove
Impurities & sent water in water body (WW treatment).
(4) Crystallizer:-

Crystallization is an important technique for the purification of

solids in the chemical process industries (CPI). The operation can be
performed batchwise or in continuous operation, and is used for a
wide variety of products, ranging from sugar, salts and other bulk
chemicals, to pharmaceuticals and other fine chemicals.

• Cooling crystallization is used in API-1 plant.

• By cooling the crystal is form of the main Ingredient.
(5) Centrifuge filter:-

• Centrifugal filters use the principle of centrifugal

force to cause liquid and solids separation.
• The purpose of a centrifuge is to take advantage
of the principles above, and use them to separate
liquids from solids.
(6) Dreyer (Nauta Dryer) :-

• The Nauta conical screw dryer is a universal vacuum dryer

for drying materials such as powders, granules, pastes and
viscous slurries.
• Industrial dryers are used to efficiently process large
quantities of bulk materials that need reduced moisture
levels. Depending on the amount and the makeup of material
needing to be dried, industrial dryers come in many different
models constructed specifically for the type and quantity of
material to be processed.
• Various factors are considered in determining the correct
type of dryer for any given application, including the
material to be dried, drying process requirements,
production requirements, final product quality requirement Nauta dryer
• PROCESS DIAGRAM:-
• PROCESS:-

• Take toluenein kettle reactor at 30°-32°C.

• Thiophenene at 30°-32°C.
• K2CO3 at 22°-25°C. & Water.
• 2-bromopropinly bromide charge by vaccum pump at 40°-
60°C.(pre-process)
• Stirr all the raw materials in kettle reactor by maintaining
temperature of reaction periodically.
(Excess of washout toluene in reactor)
• Glass lined kettle reactor is used because of this reaction is highly
acidic reaction. (Corrosion)

• After this process chemicals go through pressure filter .

• After filtration, Transfer this mass into settler, remain toluene

again used as a raw material, After settling seperate the heavy
dense & law dense layer. (aqueous/organic layer)
• Aqeous layer sent to ETP-Effluent Treatment Plant, remove Impurities &
sent water in water body (WW treatment).

• Acidic gas produces during reaction get into the scrubber. The bed is
provided in the scrubber, which have NaOH particles on it. When acidic
wash of gas occurs on the bed it gets neutralized & then it gets free to
the environment.

• The mother liquor which collected at the bottom recycle again in the
crystallizer through the condenser. Then this crystals mixture which
holds moisture base transfer to the centrifuge filters through the forced
pipe.
• The crystal & moisture mixture come to the centrifuge filter. Where separation
of mixture done on base of gravity. In the centrifuge filter drum provided with
holes which collect the solid crystal base & moisture remove out through
gravity motion.

• Then this solid crystal base goes to the nauta dryer where they brake by the
big screw shaft. The heat provides by the jacket around the dryer to remove
the least amount of moisture from it & convert into small & smooth particle
powder.

• Then this smooth powder packed into the drums & got labelled according to
the Articaine HCL MSDS & sent to the GMP area. This whole processes in API
Units manage by the SCADA & HMI Software System.
• Products in Markets:-

1. Ramilich & Ramipril

2. Metoformin Lich & Zuglimet

3. Paracetamol

4. Articaine HCL
THANK YOU