THE RELEVANCE OF NUTRIGENOMICS AND NUTRIGENETICS IN MEDICINE

BY

AKINADE, ADEMOLA MARVELLOUS

MATRIC NO: 220788

A term paper submitted to the Department of Biochemistry

Faculty of Basic Medical Sciences

In partial fulfillment for the award of the

BACHELOR OF MEDICINE, BACHELOR OF SURGERY

of the

UNIVERSITY OF IBADAN

NOVEMBER, 2022

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 ACKNOWLEDGEMENTS

I acknowledge God Almighty for the provision of life and good health. I also want to appreciate

my Supervisor, Dr. Oluwatoyin A. Adeyemo-Salami, for her motherly direction and guidance. I

will not fail to acknowledge the Head of Department, Prof. O. A. Adaramoye and also my

lecturers: Professors E.O. Farombi, Oyeronke A. Odunola, C.O.O. Olaiya, M.A. Gbadegesin,

Drs. J.O. Olugbami, J.O Olanlokun, Omolola A. Adesanoye, A.O Abolaji, A.M. Esan, I.A

Adedara, I.O Awogbindin, Olubukola T. Oyebode, S.E Owumi, A.M Adegoke and A.O.

Olowofolahan who have imparted knowledge unto me throughout my course of study. I wish to

appreciate the Non-academic staff of the Department of Biochemistry also for their various

efforts throughout the course of study.

I sincerely express my gratitude to my parents, Mr and Mrs Akinade, friends and course mates

who have all in one way or another contributed to the success of this work.

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 CERTIFICATION

I certify that this work was carried out by Ademola Marvellous AKINADE in the Department of

Biochemistry, College of Medicine, University of Ibadan under my supervision.

____________________ ____________________

Dr. Oluwatoyin A. Adeyemo-Salami MCSN Date

B.Sc, M.Sc, Ph.D (Ibadan)

Department of Biochemistry

University of Ibadan, Ibadan.

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 ABSTRACT

The interrelations between human nutrition and human gene expression are topics which have

been of great interest to the medical community for decades. The knowledge of vitamins,

minerals and other nutrients and their deficiencies have been of great importance in the treatment

of various diseases and disorders. Moreso, the fact that genes affect how nutrients are digested,

absorbed and metabolised and at the same time, nutrients also affect gene expression has allowed

us to see more into the dynamics of the human body. Nutrigenomics and Nutrigenetics, albeit

fields in their infancy are potential sources of incredible medical insights and even in their

infancy have shown themselves to be of great medical relevance.

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 TABLE OF CONTENT

Title page _______________________________________________________________ i

Acknowledgements __________________________________________________________ ii

Certification _______________________________________________________________ iii

Abstract _______________________________________________________________ iv

Table of content ___________________________________________________________ v

List of figures _________________________________________________________ vii

List of tables ____________________________________________________________ viii

CHAPTER 1 : Introduction ____________________________________________________ 1

CHAPTER 2: Nutrigenetics and nutrigenomics _______________________________ 3

2.1 Nutrigenetics and nutrigenomics ________________________________________ 3

2.2 Links between nutrigenetics and nutrigenomics _______________________ 4

CHAPTER 3: Tools for research in nutrigenomics and nutrigenetics ____________ 9

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CHAPTER 4: Applications of nutrigenetics and nutrigenomics in medicine____ 14

CHAPTER 5: Conclusion _________________________________ 17

References ____________________________________________________ 18

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 LIST OF FIGURES

Fig 1.1 The relations of genes and nutrition to nutrigenetics and nutrigenomics _ 3

Fig 1.2 Lac operon ______________________________________________7

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 LIST OF TABLES

Table 1.1 Frequencies of LCT gene variants ______________________ 5

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