You are on page 1of 5

Annals of the Royal College of Surgeons of England (1990) vol.

72, 188-192

Venous disease: investigation and


treatment, fact or fiction?
H J Scott FRCSEd P D Coleridge Smith FRCS
Research Fellow Senior Lecturer
G M McMullin FRCSEd J H Scurr FRCS
Research Fellow Consultant Surgeon
Department of Surgical Studies, University College and Middlesex School of Medicine,
The Middlesex Hospital, London

Key words: Varicose veins; Venous insufficiency; Clinical competence

This review looks at some clinical and experimental methods interest in the management of these patients? Sir
and treatments used in venous disease, and attempts to Benjamin Brodie (2) observed in 1846 "I think it very
dispel some myths which have been associated with it. Over probable that many among you pass the bedside of such a
the last century numerous techniques have been introduced patient without thinking it worthy of attention." In a
to aid the understanding of the physiology of normal legs recent survey of major London teaching hospitals only
and the pathophysiology of those with venous disease. two had ulcer clinics attended by a consultant.
Tourniquet testing along with clinical examination remains
the only method of venous assessment in most hospitals. Our understanding of the venous system has been
Venous ulceration in the past has been associated with deep severely hampered by the lack of investigative tools and
vein incompetence, but the newer, non-invasive techniques over the centuries many myths have developed. These
of Doppler ultrasound and duplex examination are now theories have included the belief that varices were full of
identifying patients with leg ulceration who have superficial black bile (3); that venous valves were to prevent blood
venous insufficiency and therefore a surgically correctable flowing into the feet and arms (4); that varicose veins
condition. were attributable to a high melancholy temper in men
Perforating veins and their possible role in the aetiology of (5); and that ulcers should be kept open to allow drainage
venous ulceration along with invasive and non-invasive meth- of evil humours (6). The last century has seen the intro-
ods for their detection is reviewed. Some of the conservative duction of numerous techniques allowing a more scien-
compression treatments and dressings available for the tific approach to venous disease, but even these have been
treatment of venous ulceration are discussed. It is concluded
that adherence to sound surgical principles remains the
subject to misinterpretation. Many myths remain preva-
mainstay of the successful management of patients with lent and this review attempts to dispel some of them.
venous disease
Before we can truly advance the treatment of venous
disorders, we need to understand the physiology and in
particular the pathophysiology leading to these prob-
lems. Clinical examination, perhaps aided by a tourni-
Venous disorders are a common problem (1). Varicose quet test, is the sole method of investigation in most hos-
veins are the most common problem seen in district pitals (7). These examinations do not give enough infor-
general hospitals, and are frequently treated without any mation to exclude arterial problems; to identify the exact
investigations, often by relatively junior and inexper- site of perforating veins, or to distinguish adequately
ienced staff. The recurrence of varicose veins following between superficial and deep venous insufficiency (8,9).
both sclerotherapy and surgical treatment is often seen. In 1868 Gay (10) and Spender (11), working indepen-
Venous disease lacks the urgency inherent in arterial dently, noted that varicose veins occurred without
disease. How many surgeons can really claim a genuine venous ulcers, and that venous ulcers could occur with-
out varicose veins; though in some cases the two con-
ditions may coexist. It is now often assumed that venous
Correspondence to: Mr J H Scurr FRCS, Department of ulcers in the absence of varicose veins are due to deep
Surgical Studies, UCMSM, The Middlesex Hospital, Mortimer venous insufficiency (DVI) (12). In our own series
Street, London WIN 8AA (13) about two-thirds of the patients presenting with
Venous disease 189
symptoms of chronic venous insufficiency, lipodermato- and infection. Many published series (38-41) report
sclerosis, ulceration and eczema, had superficial venous widely differing results with ulcer cure rates varying
insufficiency alone. This finding is supported by other from 40% (42) to 90% (43). Poor results have been
workers (14,15). attributed to missing incompetent perforating veins at
Doppler ultrasound and in particular the newer moda- surgery and the exact location of these veins remains a
lity of duplex (16) (which incorporates B mode ultra- problem. A variety of techniques have been described to
sound with Doppler) have demonstrated that incompetent identify their position. These include fluorescein injec-
valves with consequent retrograde flow of venous blood tion (44), thermography (45), infra-red photography
exists in many limbs where varicose veins are not (46), Doppler ultrasound (47) and phlebography (48,49).
clinically apparent (17). Duplex has also demonstrated The only investigation found to show significant im-
that in some cases of clinically obvious long saphenous provement over clinical examination was phlebography
varicose veins there is a competent saphenofemoral (50,51).
junction with an incompetent nearby thigh perforator. At surgery, many more veins are seen than are ever
The short saphenous system is even more variable (18). identified preoperatively and there is still no accurate
The saphenopopliteal junction may be located anywhere method for locating incompetent perforating veins.
from the mid-calf to the mid-thigh. This problem is Colour duplex may alter this.
compounded by two pairs of gastrocnemius veins (19) Venography is still considered the 'gold standard' for
into which the short saphenous vein often empties (rather venous assessment, though poor patient acceptibility and
than into the popliteal vein). Identification of the correct a significant morbidity (52) limit its use. It is time
anatomy is impossible by clinical examination. The consuming and operator dependent. In radiological
common recurrences following varicose vein surgery, departments where venograms are an occasional pro-
particularly around the popliteal fossa (20) may well be cedure performed by staff in training, results can be
attributable to incorrect identification of the vascular unsatisfactory and films difficult to interpret.
anatomy (21). Tourniquets used for identification of perforators also
Many surgeons rely on tourniquets to determine pose problems of interpretation. An ineffective tourni-
whether there is deep or superficial venous insufficiency. quet will lead to filling of the superficial rather than the
There is no standard method of application or indeed no deep veins. Cinevenography (53,54) overcomes some of
standard tourniquet which can be applied. Some large these problems, but is only used in a few specialised
superficial veins are not compressed by tourniquets, and centres.
conversely in some patients, the deep veins along with Duplex scanning has shown that short segments of
the superficial system are compressed. The results of a reflux exist within an otherwise normal venous system
tourniquet test can at best be a guide, and cannot be (55). Reflux within the common femoral vein can coexist
relied upon. Despite this, surgical treatment is planned with a competent popliteal vein. Venography is unable to
on these results. identify these abnormal segments. The significance of
The role of perforating veins in the development of regional reflux has yet to be fully elucidated.
venous ulceration remains a subject of controversy. Their Ascending venography identifies post-phlebitic
existence is undisputable and has been well documented. damage, but not primary valve failure, a condition now
Cadaveric dissections (22,23) combined with in vivo recognised as a cause of DVI (56). In this syndrome the
studies (24), have led to the description of many epony- deep veins and valves look normal on ascending veno-
mous perforating veins (25). The pathophysiology of graphy (57) and changes are only seen on descending
these veins remains uncertain. The 'blow-out theory' venography. Descending venography will show floppy
attributes the skin changes of venous disease to the valves and reversed flow (58). The interpretation of
transmission of high pressure through incompetent per- descending venograms is difficult, as some 'clinically
forating veins (26,27). There are those who believe that normal' limbs show reflux to below the knees (59,60).
no venous ulcer exists without these veins (28,29). Venography has also been used for the definitive diagno-
However, other workers have disputed this and in a sis of deep vein thrombosis (DVT) (61,62). Lensing et al.
number of cases ulceration has been shown to be solely (63) using duplex have shown 100% sensitivity and 99%
due to long saphenous insufficiency (30,31). specificity for the detection of vein thrombosis in the
Incompetent perforating veins have also been des- common femoral vein and the popliteal veins. Detection
cribed as irrelevant (32). Bjordal (33) demonstrated that of venous thrombosis in the calf and iliac veins is more
the main cause of raised venous pressure in patients with difficult.
venous insufficiency was due to reflux of blood within the Continuous-wave Doppler using a simple 5 MHz
major venous channels. He demonstrated that the incom- hand-held pencil probe, can be used to detect deep vein
petent perforating veins contribute little to this pressure. patency, vessel occlusion and flow direction at the
Nonetheless, incompetent perforating veins have con- bedside (64). Occlusion of major vessels such as the iliac,
tinued to be considered important and numerous tech- femoral and popliteal veins (which have few collaterals)
niques (34), operations (35,23) incisions and approaches can be diagnosed with this method to an accuracy of
(28,36), and instruments (37) have been described to 90%. The sensitivity is 95% and the specificity is 90%
divide them. All these procedures have been associated (65). Eklof stated that every surgeon treating varicose
with complications including haemorrhage, skin necrosis veins should have a continuous-wave Doppler in his
190 H J Scott et al.
pocket (66). However, problems exist with this investi- identify and treat those patients with a surgically treat-
gation and its reliability has been challenged by many able condition and to apply sound surgical principles to
authors (67-69). The major drawback of this procedure the management of patients with venous disorders.
is that the vessel being insonated cannot be identified,
making interpretation of the Doppler recording in
regions with a complex anatomical arrangement difficult.
When used in conjunction with tourniquets the problems References
are compounded.
Bandaging for varicose veins has been a mode of 1 Cornwall JV, Dore CJ, Lewis JD. Leg ulcers: epidemiology
treatment since the time of Hippocrates (70). Bringing and aetiology. BrJ7 Surg 1986;73:693-6.
2 Brodie B. Brodie's Lectures on Varicose Veins and Ulcers of the
patients into hospital, elevating the leg and cleaning the Legs, 1846.
ulcer results in rapid healing. Compression is thought to 3 Avicenna De Ulceribus. Lib IV 10th Cent.
be important in healing ulcers in ambulant patients, but 4 Fabricus of Aquapendents, Hieronymous. In: KJ Franklin,
how much, for how long, and how this compression trans. De Venarum Ostiolis 1603. Springfield Ill: CC
should be applied, is not known. There have been many Thomas, 1933.
successful studies demonstrating improved ulcer healing 5 Pare A. The Works of that famous Chirurgian. Ambrose Pare.
using a particular technique, a particular bandage or a London: Cotes and Du Gard, 1579.
particular dressing. Until it is known what pathophysio- 6 Sharp S. A Treatise on the Operations of Surgery. 7th Ed.
logical changes we are attempting to modify, and we have London: Tonson, 1758.
a method of monitoring these changes, we are unlikely to 7 Harding Rains HJ, Ritchie HD eds. Bailey & Love: Short
be able to design more effective regimens. Practice of Surgery, 19th Ed. London: HK Lewis, 1984:169.
8 Strandness DF, Sumner DS. Haemodynamics for Surgeons.
The first stockings and laced bandages were used by Orlando: Grune & Stratton, 1975:491.
Richard Wiseman in 1676 to repress humours impacted 9 Haeger K. Venous incompetence and concomitant diseases
in the leg (71). The application of effective graduated of the leg. 7 Cardiovasc Surg 1965;6:482-90.
compression has been the single most important factor in 10 Gay J on Varicose Disease of the Lower Extremities. The
the successful control of venous disorders. Elastic stock- Lettisomian Lecturers 1867. London: Churchill, 1868.
ings have been shown to give effective graduated com- 11 Spender JK. A Manual of the Pathology & Treatment of
pression (72-74), and have been shown to be more Ulcers and Diseases of the Lower Limb. London: Churchill,
effective than bandages (75-77). Their use has been 1868.
advocated for varicose veins, oedema, venous ulceration 12 Raju S. Venous insufficiency of the lower limb and stasis
and following surgery or sclerotherapy (78). They are ulceration-changing concepts and management. Ann Surg
more acceptable than bandages, both cosmetically and 1983;197:688-97.
13 McMullin GM, Scott HJ, Coleridge Smith PD, Scurr JH. A
for reasons of comfort and ease of use. Unfortunately, comparison of photoplethysmography, Doppler and duplex
there are a number of patients who are unable to cope in the assessment of venous insufficiency. Phlebology 1989;
with them. The Textile and Clothing Standards 4:75-82.
Committee (which included medical personnel) prepared 14 Wright D, Walton J, Meek A, McCollum CN. Venous
the British Standard BS6612: 1985 in 1985 (79). This led ulceration is not usually 'post phlebitic'. Jf Cardiovasc Surg
to the revision of the Drug Tariff allowing National 1987;28:99.
Health Service prescriptions of stockings on FP10s. 15 Christopoulos D, Nicolaides AN, Szendro G. Venous re-
Nevertheless there are still venous clinics operating flux: quantification and correlation with the clinical severity
where stockings are not provided. of chronic venous disease. Brj Surg 1988;75:352-6.
In an attempt to heal ulcers many creams, pastes and 16 Flanagan LD, Sullivan ED, Cranley JJ. Venous imaging of
dressing materials have been described. More than 100 the extremities using real time B mode ultrasound in
different products have been advanced, many claiming surgery of the veins. In: Bergan JJ, Yao JST eds. Surgery of
the Veins. Orlando: Grune & Stratton, 1985.
magical cures for venous ulceration. Whilst the possibility 17 Gooley NA, Sumner DS. Relationship of venous reflux to
of modifying wound healing remains, with the use of the site of venous valvular incompetence: implications for
growth factors, our current generation of products rely venous reconstructive surgery. j Vasc Surg 1988;7:50-9.
on modifying the wound environment. Reducing infec- 18 Corcos L, Peruzzi G, Romeo V, Fiori C. Intraoperative
tion is clearly important, and the application of paste phlebography of the short saphenous vein. Phlebology
bandages producing an environment similar to the septic 1987;2:241-8.
tank aims to hold bacterial contamination at levels in 19 Hobbs JT. The enigma of the gastrocnemius vein.
which wound healing can take place. Hydrocolloid dress- Phlebology 1988;3:19-30.
ings have been advocated in producing a moist environ- 20 Corbett CR, McIrvine AJ, Aston NO, Jamieson CW, Lea
ment. Other dressings claim active properties promoting Thomas M. The use of varicography to identify sources of
wound healing. Whatever the advantages or disadvan- incompetence in recurrent varicose veins. Ann R Coll Surg
Engl 1984;66:412-15.
tages of these dressings, adequate debridement, regular 21 DeGroot WP. Failure in surgery of the long and short
cleansing and good compression must remain the hall- saphenous vein. Phlebologie 1988;41:746-9.
mark of proper treatment. 22 Thomson H. The surgical anatomy of the superficial and
This paper questions our approach to patients with perforating veins of the lower limb. Ann R Coll Surg Engl
venous disorders. It remains essential to correctly 1979;61: 198-205.
Venous disease 191
23 Linton R. The communicating veins of the lower leg and 47 Negus D, Friedgood A. The effective management of
the operative technique for their ligation. Ann Surg venous ulceration. BrJ7 Surg 1983;70:623-7.
1938;107:582-93. 48 Chant ADB, Jones HO, Townsend JCF, Edmund Williams
24 Dodd H, Cockett FB. The Pathology and Surgery of the Veins J. Radiological demonstration of the relationship between
of the Lower Limb. Edinburgh & London: Livingstone, calf varices and sapheno femoral incompetence. Clin
1956. Radiol 1972;23:519-23.
25 Browse NL, Burnand K, Lea Thomas M. Diseases of the 49 Lea Thomas M, McAllister V, Rose DH, Tonge K. A
Veins: Pathology, Diagnosis and Treatment. London: Edward simplified technique of phlebography for the localisation of
Arnold, 1988:44-6. incompetent perforating veins of the legs. Clin Radiol
26 Cockett FB, Jones DEE. The ankle blow out syndrome. 1972;23:486-91.
Lancet 1953;1:1-17. 50 O'Donnell T, Burnand K, Clemsen G, Thomas ML,
27 Arnoldi CC, Linderholm H. On the pathogenesis of the Browse N. Doppler examination vs clinical and phlebo-
venous leg ulcer. Acta Chir Scand 1968;134:427-40. graphic detection of the localisation of incompetent perforat-
28 Dodd H. The diagnosis and ligation of incompetent ankle ing veins. Arch Surg 1977;112:31-5.
perforating veins. Ann R Coll Surg Engl 1964;34:186-96. 51 Noble J, Gunn AA. Varicose veins: comparative study of
29 Haeger K. Leg ulcers. In: Hobbs JT ed. The Treatment of methods for detecting incompetent perforators. Lancet
Venous Disorders. Lancaster: MTP Press Ltd, 1977:276. 1972;1: 1253-5.
30 Sethia KK, Darke SG. Long saphenous incompetence as a 52 Bettman MA, Paulin S. Leg phlebography: the incidence,
cause of venous ulceration. BrJ7 Surg 1984;71:754-5. nature and modification of undesirable side effects.
31 Wright DDI, Greenhalgh RM, McCollum CN. The role of Radiology 1977;122:101-4.
superficial venous surgery in healing chronic venous ulcers. 53 Gray-Weak AC, de Burgh MM, Lippey E, Palme A.
Phlebologie 1988;41:792-3. Ascending cinevenography in chronic venous insuffi-
32 Recek C. A critical appraisal of the role of ankle perforators ciency-a comparison with ambulatory venous pressure
measurements. Aust N ZJ7 Surg 1985;55:565-9.
for the genesis of venous ulcers in the lower leg. J 54 Field ES, Kakkar VV, Stephenson G, Nicolaides AN. The
Cardiovasc Surg 1971;12:45-9. value of cinephlebography in detecting incompetent venous
33 Bjordal R. Circulation patterns in incompetent perforating valves in the post phlebitic state. Br7 Surg 1972;59:304.
veins in the calf and in the saphenous system in primary 55 Szendro G, Nicolaides AN, Zukowski AJ et al. Duplex
varicose veins. Acta Chir Scand 1972;138:257-61. scanning in the assessment of deep venous incompetence. J
34 Edwards JM. Shearing operation for incompetent perforat- Vasc Surg 1986;4:237-42.
ing veins. Brj Surg 1976;63:885-6. 56 Kistner RL. Primary venous valve incompetence of the leg.
35 Cockett FB. Diagnosis and treatment of venous ulcers of Am J Surg 1980;140:218-24.
the leg. Br J Surg 1955;43:260-2. 57 Train JS, Schanzer H, Converse Peirce E, Pan SJ, Mitty
36 De Palme R. Surgical therapy for venous stasis. Surgery HA. Radiological evaluation of the chronic venous stasis
1974;76:910-16. syndrome. jAMA 1987:258:941-4.
37 Petrov ML, Penin VA. Khirurgicheskoe Lechienie pri 58 Herman RJ, Neiman HL, Yao ST. Descending veno-
posttromboflebitcheskom sindrome, Vestn Khr 1976;116: graphy: a method of evaluating lower extremity venous
48-50. valvular function. Radiology 1980;137:63-9.
38 Field P, Van Bosl P. The role of the Linton Flap procedure 59 Ackroyd JS, Browse NL. The investigation and surgery of
in the management of stasis dermatitis and ulceration in the the posz thrombotic syndrome. J Cardiovasc Surg 1986;27:
lower limb. Surgery 1971;70:920-6. 5-16.
39 Silver D, Greysteen JJ, Rhodes GR, Georgiade NG, Anyam 60 Thomas ML, Keeling FP, Ackroyd JS. Descending
WG, Durham NC. Surgical treatment of the refractory post phlebography: a comparison of three methods and an
phlebitic ulcer. Arch Surg 1971;103:554-8. assessment of the normal range of deep vein reflux. J
40 Hyde GL, Litton TC, Hull DA. Long term results of Cardiovasc Surg 1986;27:27-30.
subfascial vein ligation for venous stasis disease. Surg 61 Lea Thomas M. Phlebography. Arch Surg 1972;104:145-
Gynecol Obstet 1981;153:683-5. 51.
41 Wilkinson GE, Maclaren IF. Long term review of 62 Ravinow K, Paulin S. Roentgen diagnosis of venous
procedures for venous perforator insufficiency. Surg thrombosis in the leg. Arch Surg 1972;104: 134-44.
Gynecol Obstet 1986;163: 117-20. 63 Lensing AWA, Prandoni P, Brandjes D et al. Detection of
42 Burnand K, Lea Thomas M, O'Donnell T, Browse NL. deep vein thrombosis by real time B mode ultrasonography.
Relation between post phlebitic changes in the deep veins N Engl _J Med 1989;320:342-5.
and results of surgical treatment of venous ulcers. Lancet 64 Folse R, Alexander RH. Directional flow detection for
1976;1:936-8. localising venous valvular incompetency. Surgery 1970;67:
43 Negus D. Prevention and treatment of venous ulceration. 114-20.
Ann R Coll Surg Engl 1985;67: 144-8. 65 Sumner DS. Diagnosis of deep venous thrombosis by
44 Chilvers AS, Thomas MH. Method for the localisation of Doppler ultrasound. In: Nicolaides AN, Yao ST eds.
incompetent ankle perforating veins. Br Med j 1970;1: Investigation of Vascular Disorders. London and Edinburgh:
577-9. Churchill Livingstone, 1985.
45 Patil KD, Williams JR, Lloyd Williams K. Thermographic 66 Eklof B. Modern treatment of varicose veins. Br j Surg
localisation of incompetent perforating veins of the leg. Br 1988;75:297-8.
MedJf 1970;1:195-7. 67 Scott Norris C, Beyrav A, Barnes RW. Quantitative photo-
46 Beesley WH, Fegan WG. An investigation into the plethysmography in chronic venous insufficiency: a new
localisation of incompetent perforating veins. Br J Surg method of non-invasive estimation of ambulatory venous
1970;57:30-2. pressure. Surgery 1983;94:758-64.
192 H J Scott et al.
68 Hobbs JT. Errors in the differential diagnosis of incompe- 74 Jones NAG, Webb PJ, Rees RI, Kakkar VV. A physio-
tence of the popliteal vein by Doppler ultrasound. J logical study of elastic compression stockings in venous
Cardiovasc Surg 1986;27:169-74. disorders of the leg. BrJ Surg 1980;67:569-72.
69 Colgan MP, Sumner DS. How does a vascular laboratory 75 Tennant WG, Park KGM, Ruckley CV. Testing compres-
influence management of venous disease? In: Greenhalgh sion bandages. Phkebology 1988;3:55-61.
R, Jamieson CW, Nicolaides AN. eds. Vascular Surgery 76 Coleridge Smith PD, Scurr JH. Optimum methods of limb
Issues in Current Practice. Orlando: Grune & Stratton, compression following varicose vein surgery. Phkebology
1986:119-34. 1987;2: 165-72.
70 Hippocrates. Leg ulcers. Their causes and treatment. Anning 77 Wright DDI, Munro C, McCollum CN. How good are
ST, trans. London: J & A Churchill Ltd, 1954. elastic bandages? Phlebologie 1988;41:794-5.
71 Wiseman R. Several Chirurgical Treatises. London: Rogstan 78 Scurr JH, Coleridge Smith PD, Cutting P. Varicose veins:
& Took, 1676. optimum compression following sclerotherapy. Ann R Coll
72 Burnand KG, Layer GT. Graduated elastic stockings. Br Surg Engl 1985;67:109-11.
MedJf 1986;293:224-5. 79 British Standards Institution. BS6612:1985. British Stan-
73 Somerville JJF, Brow GC, Byrne PJ, Quill RD, Fegan WG. dard Specification for Graduated Compression Hosiry, 1985.
The effect of elastic stockings on superficial venous pres-
sures in patients with venous insufficiency. Br J Surg Received 19 October 1989
1974;61:979-81.

Book review
Complications of Plastic Surgery by A McG Morris, special note as opposed to those which are not. To exclude any
J H Stevenson, A C H Watson. 442 pp, illustrated. specific mention of the problem of the burned hand, a common
Bailliere Tindall, London 1989. £52.50. ISBN 0 7020 1360 9 enough condition, but to include Marjolin's ulcer which is rare,
Plastic surgery is a technical rather than a diagnostic specialty. is a case in point. It is insufficiently emphasised that exposure
Its fascination lies in the restoration of function and the of the cornea demands early, even emergency, grafting if the
correction of deformity using a wide variety of techniques eyelid is to provide corneal cover and to even hint to the
which the surgeon tailors to each patient's needs and which inexperienced surgeon that to perform multiple z-plasties, to
require skill, judgement, and experience in their selection. supposedly improve the appearance of scarring, will help to
There is a temptation among those not trained in the specialty perpetuate folly and encourage complications which the book
to read about the techniques, seemingly of apparent simplicity, seeks to warn against.
and to be beguiled into applying them without thought or Future editions will undoubtedly be modified and a chapter
knowledge of the complications that can ensue. The results of on the medico-legal aspects of patient counselling and care in a
such ignorant meddling can be disastrous for the patient and a specialty which is increasingly assailed by potentially litigious
source of great difficulty to the plastic surgeon, who is then and dissatisfied patients should be included. Finally, it is to be
called in to solve an avoidable problem. hoped that future editions will have the text squarely placed on
This little volume should be required reading for all sur- the page and not askew as it is in the reviewer's copy.
geons, as it highlights the difficulties and dangers in a concise J P BENNETT
way, aided by useful photographs and clear diagrams. As can Consultant Plastic Surgeon
happen with multi-author books, it is uneven and there is Queen Victoria Hospital
sometimes a lack of emphasis on which complications are of East Grinstead

You might also like