Pharmaceutical Dosage Forms Laboratory Manual

Name: Sec: Group no.: Date:

SN Surname, First name

PREPARATION #6: GLYCERIN SUPPOSITORIES

Post Lab Questions:

1. Identify and tabulate at least three commercially available suppositories (vaginal

and rectal), their brand name, active constituent/s, strength, and indication/s.

Brand name Active Strength Indication/s

Constituent/s

Neo-Penotran - Metronidazole -750 mg Treatment of vaginal candidiasis due to Candida

Forte - Miconazole -200 mg albicans, bacterial vaginitis due to anaerobic bacteria and
(vaginal nitrate Gardnerella vaginalis, trichomonal vaginitis due to
suppository) Trichomonas vaginalis, and mixed vaginal infections.

Dulcolax -Bisacodyl -5 mg Constipation, either chronic or of recent onset, whenever a

(rectal suppository) stimulant laxative is required. Bowel clearance before
surgery or radiological investigation. Replacement of the
evacuant enema in all its indications.

Cleocin (vaginal -Clindamycin -100 mg Indicated for 3-day treatment of bacterial vaginosis in
suppository) Phosphate non-pregnant women. There are no adequate and
well-controlled studies of CLEOCIN Vaginal Ovules in
pregnant women.

Neo-Penotran/Neo-Penotran Forte/Neo-Penotran Forte-L Full Prescribing Information, Dosage &

Side Effects | MIMS Philippines. (2022). MIMS.
https://www.mims.com/philippines/drug/info/neo-penotran-neo-penotran%20forte-neo-penotran%20for
te-l?type=full

Dulcolax 5 mg Suppositories - Summary of Product Characteristics. (2021). Emc.

https://www.medicines.org.uk/emc/product/5505/smpc#gref

CLEOCIN- clindamycin phosphate suppository. (2021). DailyMed.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3db26227-208d-4fdd-8426-1d9be5cda9b4

2. What are the most preferred method of preparation and the advantages of using
this method?
There are three main methods used for preparing Glycerin suppositories such as: 1) the
fusion method which involves molding from a melt, 2) hand molding or shaping, and 3) Compression
which may be by a tablet press or cold compression. The most preferred method of preparation
among these methods is the fusion method wherein the suppository base is melted in this
procedure, then the medicine is dispersed/dissolved in the melted hot suppository base. The slurry
is then placed into a lubricated suppository molder and allowed to cool and form before being
removed from the molder and wrapped. One of the benefits of this procedure is that it takes a short
amount of time to complete, compared to hand rolling which can only be done on a small scale and
requires skill. The fusion method can be done in both small and large scale approaches. Molders
are also provided when using this approach, ensuring that the suppositories are uniform in size.

3. Aside from the previously discussed types of suppositories, what are the other
kinds of suppositories?

- The discussion mentioned rectal, vaginal, and urethral suppositories. Nasal and aural
suppositories were mentioned, but not discussed in detail.
- Nasal suppositories are also known as burginariums. They are introduced in the nasal cavity,
and are prepared from a glycerogelatin base. They usually weigh around 1 gram, with a
length of 9 to 10 cm.
- Aural suppositories, also known as aurinariums and ear cones, are rarely used. Theobroma
oil is used as a base. These are cylindrical in shape and weigh around 1 gram.
- The textbook also goes in depth about altered release suppositories, such as long-acting
and slow-release suppositories. For example, morphine sulfate is prepared with alginic acid
to create a slow-release suppository, releasing the active ingredients over several hours.
Various coatings, emulsions, hydro gels, micellar solutions, thermoreversible liquid
suppositories, xerogel suppositories, and others have been investigated in their effectiveness
to slow down, speed up, and/or prolong the release of the drug.