til ater soluble fit -

Biz

Introduction :

°
Also known as Cobalamin .
extrinsic factor ( EF ) of Castle and
Anti pernicious anemia
factor .

• Hit Biz in water soluble ,

heat stable and red in colour .

Contains cobalt wt
4.35%
by
°
.

°
Hit Biz I cobalt atom coordinated with

a cobalt atom ( Corrin Ring )

and benz imidazole
one
ring .

Absorption of lit Biz :

cis
Absorption of lit Biz requires two binding
protein .

( at
factor (
Intrinsic in
gastric juice )
bi
(
Cobalophilin ( in saliva )

ciii
pepsin release the
Gastrin vitamin

From proteins of food and then

Biz binds with cobalophilin .

ciiis In duodenum cobalophilin fit

. in hydrolysed by trypsin and in

released and binds to Intrinsic factor .

mol.rs Intrinsic combine with molecules

civi One
factor can 2
og Biz .

attached with specific receptor muggy;D

This IF -

Biz complex in on

The whole IF -

complex
Biz internalized It may
in . be noted

absorbed from ileum

that Biz in while
folic acid ,
in
from jejunum .
 In blood
methyl Biz form in
°

predominant .

•
Frans cobalamin ,
a
glycoprotein .
in

specific carrier .

• It is stored in the liver cells ,

as

a do -

Biz form ,
in combination
with trans comin .

Generally B complex are not stored

in
body . Biz in an
exception .

Int hole liver contains about

.

2mg 9 Biz
( sufficient for 2-3
yrs )

Caunes of Vit Biz

Deficiency :

Nutritional India
in - Hit Biz
deficiency very
in common in .

Only source
og Bu in
vegetarian diet in curd / milk .

(2)
becreaseabso-rpk.com Malabsorption syndromes : or
Gastrectomy .

(3) AdcbPm Anemia : Autoimmune disease with

strong
familial background .

Antibodies generated against IF are .

-
so IF I
defective absorption a lit
.
. Biz .

( 41 Giant trophy :
Atrophy a Gastric epithelium → IF I →
Biz it.

requirement of vitamin
153
Pmg : Inc .
in
pregnancy
in

another came
og
Hit Biz
deficiency .

Fishtown Tapeworm has special

16 ) to
affinity Biz causing
:

seduction in available wit

[ Not India ]
'

seen in .
 Deficiency Manifestation :

cis folate trap

iii , Meg aloblaslic anemia

ciiis Abnormal
homocysteine level .

civ , Demyelination
can Subacute combined
degeneration .

His Achlorhydria

Source of lit Biz

° Not present in
vegetables .

• liver in richest source .

•
Curd in
good source .

Requirement -
I -2
Mgl day

Pregnancy =

2mg Hay