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Rheology
Physical Pharmacy II
Zainab A. Radhi
Assistant Lecturer in pharmaceutics
Outlines
• Introduction
• Viscosity
• Newtonian Systems
• Non-Newtonian Systems
• Thixotropy
Introduction
The term rheology is derived from the Greek words rheo “to
flow,” and logos “science”. It is defined as the study of the flow of
liquids and deformation of solids.
a single value.
Unit of viscosity
• The unit of viscosity is the poise, defined as the shearing force
• A more convenient unit for most work is the centipoise (cp, plural
𝜂 = AeEvRT
where A is a constant depending on the molecular weight and molar
volume of the liquid and EV, is an "activation energy" required to initiate
flow between molecules.
Non-Newtonian Systems
The majority of fluid pharmaceutical products are not simple liquids and do
not follow Newton's law of flow. These systems are referred to as non-
Newtonian.
Once the yield value has been reached, the relationship between
The more flocculated the suspension, the higher will be the yield
value.
2.Pseudo-plastic Flow
Many pharmaceutical products, including liquid dispersions of natural
and synthetic gums (e.g., sodium alginate, and methylcellulose) exhibit
pseudoplastic flow.
or FN = 𝜂' G
3. Dilatant flow
Certain suspensions with a high percentage of dispersed solids exhibit an
increase in resistance to flow with increasing rates of shear. Such
systems actually increase in volume when sheared and are hence termed
dilatant.
THIXOTROPY
Several types of behavior are observed when rate of shear is progressively
increased and plotted against resulting shear stress.
𝑼𝟏−𝑼𝟐
B= 𝒕
𝒍𝒏 𝒕𝟐
𝟏
shear rates. (The maximum shear rate is different; the time of holding
𝑈1−𝑈2
M= 𝑣
ln ( 2)
𝑣1
rheopexy.
when gently shaken than when allowed to form the gel while the
material is kept at rest. In a rheopectic system, the gel is the
equilibrium form, whereas in antithixotropy, the equilibrium state is
the sol.
DETERMINATION OF RHEOLOGIC PROPERTIES
Choice of Viscometer
For Newtonian system, because shear rate is directly proportional to
shearing stress, instruments that operate at a single shear rate can be
used. These "single-point" instruments provide a single point on the
rheogram; extrapolation of a line through this point to the origin will
result in a complete rheogram.
For Non-Newtonian, a single-point determination is virtually useless
in characterizing its flow properties. It is therefore essential that, with
non-Newtonian systems, the instrument can operate at a variety of
shear rates. Such multipoint instruments are capable of producing a
complete rheogram for non-Newtonian systems.
VISCOELASTICITY
1. Fluids
a) Mixing
2. Quasisolids
a) Spreading and adherence on the skin.
b) Removal from jars or extrusion from tubes.
c) Capacity of solids to mix with miscible liquids.
d) Release of the drug from the base.
3. Solids
a) Flow of powders from hoppers and into die cavities in tableting or
into capsules during encapsulation.
b) Package-ability of powdered or granular solids.
c) Processing.
d) Production capacity of the equipment.
e) Processing efficiency.