Common variable immunodeficiency (CVID) is an immune disorder characterised via

impaired B cellular differentiation with hypogammaglobulinemia. The ailment is associated

with a vast spectrum of scientific manifestations, such as recurrent infections, chronic lung
disease, gastrointestinal sickness, and autoimmune problems. The cornerstone of therapy is
immune globulin alternative, which has dramatically altered the medical direction of CVID
by way of decreasing the load of recurrent infections and next headaches. Management
additionally entails vigilant monitoring and appropriate remedy for associated problems,
which include pulmonary harm, gastrointestinal, autoimmune, and granulomatous sicknesses,
and malignancy [1]. The remedy and health upkeep of sufferers with CVID may be
mentioned right here, with an emphasis on adults. The medical manifestations, prognosis, and
pathogenesis of this ailment and problems mainly applicable to pediatric sufferers are
provided separately. (See "Clinical manifestations, epidemiology, and analysis of
commonplace variable immunodeficiency in adults" and "Common variable
immunodeficiency in kids" and "Pathogenesis of commonplace variable
immunodeficiency".)