TOPIC 4: Analysis of Drugs in Pharmaceutical Industry

31. The chromatography technique is based on a _ interplay between the sample and two other
substances.
Answer: Polarity
32. The _ solvent flows the solid phase.
Answer: Eluting
33. Used for separating a mixture of chemical substances into their individual components so that
the individual components can be thoroughly analyzed.
Answer: Chromatography
34. Two phases in chromatography. (Input your answers alphabetically).
Answer: Mobile / Mobile phase
35. Two phases in chromatography. (Input your answers alphabetically).
Answer: Stationary / Stationary phase
36. Is a chromatographic technique used for the separation of volatile compounds. These volatile
compounds are the compounds that easily gets vaporized at room temperature.
Answer: Gas chromatography
37. (TRUE or FALSE) The more volatile molecules interact more with the stationary phase and moves
slowly.
Answer: False
38. (TRUE or FALSE) The more volatile molecules interact more with the mobile phase and moves
fast down the column.
Answer: True
39. Due to the properties of supercritical fluids, this type of chromatographic technique combines
each of the advantages of both GC and HPLC in one method.
Answer: Supercritical fluid chromatography
40. Is a chromatographic technique in which separation occurs, based on the specific interaction
between two molecules. This specific interaction can be between enzyme and substrate,
receptor and ligand, protein and nucleic acid etc.
Answer: Affinity chromatography
41. Volumetric analysis is often referred to as __, a laboratory technique in which one substance of
known concentration and volume is used to react with another substance of unknown
concentration.
Answer: Titration
42. It is an analytical method for determining the concentration of an acid or base by accurately
neutralizing them with a known concentration standard solution of either acid or base.
Answer: Acid-base titration
43. In this type of titration, the chemical reaction takes place with a transfer of electrons in the
reacting ions of aqueous solutions.
Answer: Redox titration
44. This is a type of titration that is based on the insoluble precipitate formation when the two
reacting substances are brought into contact.
Answer: Precipitation titration
45. In this type of titration, it is where an undissociated complex is formed at an equivalence point.
Answer: Complexometric titration
46. The ____ is added to the analyte solution in order to show the end point or the completion of
the reaction.
Answer: Indicator
47. In the acid-base reaction titration of vinegar, what standard solution is used as the titrant.
Answer: Sodium hydroxide
48. A substance that reacts ________ and ________ to produce a complete solution is chosen.
Answer: Rapidly, Completely / Rapidly, completely
49. The number of moles of solute present in one liter of solution.
Answer: Molarity
50. The number of moles of solute in a solution corresponding to 1 kg of solvent.
Answer: Molality
51. Select the two areas of research in radio-frequency spectroscopy.
Answer: Nuclear magnetic resonance (NMR) and Electron paramagnetic resonance (EPR)
52. Resonance-ionization spectroscopy employs lasers to eject electrons from selected types of
atoms or molecules, splitting the neutral species into a ______ and a free electron with a
negative charge.
Answer: Positive ion
53. What law describes the relationship between light absorption and concentration?
Possible Answers: Beer-lambert law / Beer lambert law
54. The concentration of molecules in a ______ is typically very low, so the measurement using
Raman spectroscopy is often more challenging.
Answer: Gas
55. In ion exchange chromatography, what type of exchanger makes use of positively charged resin
packing?
Answer: Anion exchanger
56. The step in column chromatography wherein samples already dissolved in starting buffer
solution are added to the column.
Answer: Loading
57. _____________ is the process of determining the highest spectral similarity between the
measured spectrum of an unknown material against all spectra in a reference library.
Answer: Raw material identification
58. In infrared spectroscopy, different functional groups have different and characteristic
_____________.
Answer: Absorption frequencies
59. Compared to infrared spectroscopy, these energy present in the ___________ range are
sufficient to promote or excite a molecular electron to a higher energy orbital.
Possible Answers: Ultraviolet
UV
Visible
60. In nuclear magnetic resonance chromatography, if an external magnetic field is applied, an
energy transfer is possible between the base energy level to a ___________ level.
Answer: Higher energy