Neoplasia

(Part Two)
 GROSS PATHOLOGY/ A COLOUR ATLAS BY
R.C.CURRAN and E.L.JONES

Hemangioma: Liver
Subcapsular brown spongy hemorrhagic mass (arrow) in
the liver.
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Hemangioma: Skin
Dermal proliferation of capillary sized blood vessels lined
by normal- looking endothelial cells.
 COLOR ATLAS of HISTOPATHOLOGY BY R.C.CURRAN

Hemangioma: Skin
Dermal proliferation of blood vessels lined by normal looking
endothelial cells in the upper dermis.
 GROSS PATHOLOGY/ A COLOUR ATLAS BY R.C.CURRAN and E.L.JONES

Multiple leiomyomas: Uterus

Multiple intramural and subserosal masses (multiple leiomyomas).
 GROSS PATHOLOGY/ A COLOUR ATLAS BY R.C.CURRAN and E.L.JONES

Multiple leiomyomas: Uterus

Cross section of the lesion in the previous slide. Multiple
submucosal, intramural and subserosal masses. Cut section of the
masses is gray in color and has a whorled appearance.
 COLOR ATLAS of HISTOPATHOLOGY BY R.C.CURRAN

Leiomyoma: Uterus
Interlacing bundles of benign smooth muscle cells.
No cellular atypia, no mitotic figures and no necrosis.
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Leiomyosarcoma: Uterus
Interlacing bundles of malignant smooth muscle cells with marked
cellular atypia and frequent mitotic figures (arrows).
 https://webpath.med.utah.edu/FEMHTML/FEM034.html.html

Leiomyosarcoma: Uterus
Marked cellular atypia with mitotic figures (arrows) and tumor
giant cell.
 ROSAI AND ACKERMAN'S SURGICAL PATHOLOGY

Leiomyosarcoma: Uterus
Malignant smooth muscle tumor with area of tumor
cell necrosis and atypical mitotic figure (arrow).
Osteosarcoma:
Humerus
White lobular tumor
masses filling and
expanding the medulla,
invading and
destroying the cortex,
periosteum and the
surrounding tissues.
The tumor involves the
metaphysis and extends
to the diaphysis.

GROSS PATHOLOGY/ A COLOUR ATLAS BY R.C.CURRAN

and E.L.JONES
Osteosarcoma:
Bone
White lobular tumor
masses filling and
expanding the
medulla, invading
and destroying the
cortex, with
elevation and
destruction of the
periosteum and the
surrounding
muscles.
The tumor involves
the metaphysis and
extends to the GROSS PATHOLOGY/ A COLOUR ATLAS BY
R.C.CURRAN and E.L.JONES
diaphysis.
 Robbins Basic Pathology 9th edition

Osteosarcoma: Bone
Malignant osteoblastic proliferation with direct osteoid formation
(bone matrix-white arrow) by tumor cells. The tumor cells have
marked atypia with atypical mitotic figures (black arrows).
 CURRANS ATLAS of HISTOPATHOLOGY

Osteosarcoma:Bone
Malignant osteoblastic proliferation with direct osteoid formation
(bone matrix-double head arrow) by tumor cells. The tumor cells
have marked atypia with atypical mitotic figures (thin arrows).
 COLOR ATLAS of HISTOPATHOLOGY
BY R.C.CURRAN

Lymphatic spread of carcinoma: Lymphatic vessel

Clusters of malignant epithelial cells (tumor cells emboli) (arrows)
within a lymphatic vessel. The arteriole on the left side is tumor free.