Pharmacy Department

FIFTH LONG QUIZ in PHARMACOLOGY 1

Chapters 16, 18 & 20
First Semester, SY 2021-2022

PLEASE READ THE INSTRUCTIONS CAREFULLY AND FOLLOW THEM PROPERLY. ANSWER THE
ESSAY QUESTIONS USING YOUR OWN WORDS. REFRAIN FROM COPYING THE BOOK. SUBMIT
ON TIME TO AVOID DEDUCTIONS.

TEST 1: ESSAY TYPE: 30 POINTS

1. DISCUSS THE PATHOGENESIS AND ITS MANAGEMENT OF THE FOLLOWING DISEASES:

A. ASTHMA
B. COPD

2. DESCRIBE THE EFFECTS OF PROSTAGLANDINS AND THROMBOXANES ON THE SMOOTH

MUSCLE IN THE:
A. VASCULATURE C. GASTROINTESTINAL TRACT
B. AIRWAYS D. REPRODUCTIVE TRACTS

3. GIVE THE CLINICAL USES OF EICOSANOIDS:

A. FEMALE AND MALE REPRODUCTIVE SYSTEMS
B. CARDIOVASCULAR AND RESPIRATORY SYSTEMS
C. IMMUNE AND GASTROINTESTINAL SYSTEMS

TEST II: SIMPLE MULTIPLE CHOICE: CHOOSE THE CORRECT ANSWER AND WRITE THE LETTER
ONLY.

_______1. This/these is/are the only single-agent non amphetamine drug/s currently approved
in the USA for the treatment of obesity:

A. Orlistat. C. sibutramine
B. Lorcaserin D. rimonabant E. A&B only

_______2. The 5-HT agonist that is used almost exclusively for migraine headache:

A. Propranolol C. sumatriptan
B. amitriptyline D. flunarizine. E. all
_______3. It is a synthetic ergot compound that has been used in the laboratory as a potent
peripheral 5-HT2 antagonist while its behavioral effects are mediated by agonist
effects at the pre or post junctional receptors.
A. Bromocriptine C. ergotamine.
B. ergonovine D. LSD. E. methylsergide
_______4. Activation of H3 receptors decreases transmitter release from histamininergic and
other neurons, mediated by a decrease in calcium influx through this calcium
channels in nerve ending:
A. L-type channel C.T-type channel
B. N-type channel D. all E.none
_______5. It is a powerful bronchodilator, when given in aerosol form but it also promotes
coughing:
A. PGE2 B. PGF2 C. PGD2 D. PGI2 E. PGE1
_______6 The nonallergic stimulus/li which can provoke an asthma attack include/s:

A. Exercise C. cigarette smoke

B. cold air D. sulfur dioxide E. all

_______7. This methylxanthine cause mild cortical arousal with increased alertness and
deferral of fatigue that may lead to nervousness and insomnia.

A. Aminophylline C. theophylline
B. caffeine D. Theobroma E. none

_______8. This selective inhibitor of PDE4 has been approved by the FDA as a treatment for
COPD, though not for asthma in USA.

A. Omalizumab C. Roflumilast
B. Zileuton D. Montelukast E. none

_______9. A special problem caused by inhaled topical corticosteroid is the occurrence of:

A. Oropharyngeal candidiasis C. diarrhea

B. cough D. all E. none

______10. Greater bronchodilation with less toxicity from systemic absorption, is achieved by
treatment with this selective quaternary ammonium derivative of atropine ln acute
asthma:

A. Triotropium C. theophylline
B. aclidinium D. ipratropium E. all
TESTIII. IDENTIFICATION TYPE: Write the correct words or terms on blanks provided before
the numbers:

1. It is brought about by intradermal injection of histamine leading to its

characteristic red spot, edema and flare response.
2. It is a chemoreceptor reflex due to activation of 5-HT receptors on
afferent vagal nerve causing marked bradycardia and hypotension.
3. It is associated with skeletal muscle contractions and precipitated when
MAO inhibitors are given with serotonin agonists, especially
antidepressants of selective serotonin reuptake inhibitor class.
4. The term used in ergot poisoning during medieval times due to his
intercession in the relief of burning pain of vasospastic ischemia.
5. It is an effective, rapidly acting bronchodilator, when injected
subcutaneously or inhaled as microaerosol from a pressurized canister.
6. The disease characterized by airflow limitation that is not fully reversible
with bronchodilator treatment, most often a consequence of prolonged
habitual cigarette smoking.
7. The immune globulin that is produced when the body is exposed to
allergen like house dust mites, cockroach, animal danders, molds and
pollens.
8. The warning issued by the FDA due to risk, especially in African
Americans patient in the treatment of asthma using a long-acting B-
agonist and ICS which can significantly increase the incidence of low risk
or near -fatal asthma attack.
9. The group of drugs that block both prostaglandin and thromboxane
formation by reversibly inhibiting COX activity.
10. This PGE2 analog is commonly used by local application to promote
labor through ripening of the cervix which can lead to a faster induction
of labor.

TEST IV: SIMPLE MATCHING TYPE: MATCH COLUMN A WITH COLUMN B:

COLUMN A COLUMN B
ORGAN EFFECT EICOSANOIDS PROSTAGLANDIN INVOLVED

______1. Sleep-wakefulness A. PGE2 and PGI2

______2. Fever -increase body temperature B. PGD2 and PGI2
______3. Uterine contraction C. PGF2a and TXA
______4. Platelet aggregation – inhibition D. PGF2a and PGE2
______5. Respiratory smooth muscle -relaxation E. PGE2 only
 *****************

COLUMN A COLUMN B
DRUG OF CHOICE CLINICAL DISORDERS

______6. Acute asthma, severe A. epoprostenol

______7. COPD B. indomethacin
______8. Pulmonary hypertension C. alprostadil
______9. Patent ductus arteriosus D. O2, albuterol / systemic corticosteroids
______10. Erectile dysfunction E. LABA/triotropium/ICS