Olga-Mihaela Dorobay (he a9 came (9p Clase, 1c BACTERIOLOGIE MEDICALA -1997-| Lumea bacterilor ; Bacteriologa medcalt are ca obit uta bacteria are pot deteminn oli infetoae ta om, Basternloga ese pare Murchsigit altar de ‘insole, Micolegseq Parzclape, Ege cir fin ren pen pina ttt de Aone von Lzcuvenkoe (1634-1768). Pin oozes ul ticsoxcop tlie fu mae R300 Leeuwenhoek chneva misi“aimalue” invisible x echo Htc, fate cae relia tio srsoure tins Ii Bash Royl Society to 7 seni Toe Deseele aes mii animale seas form de slr, beans sl ces oe ‘ospnde moll de a bacteilor. ‘Totus! sul tacerilor cep de aba osc XX pin conti oud ‘mai pera: Lous Pat Reber Koch, Louis Pstout (142-1895) preesr de chime la Unvesiaesdin Lil | Frans, «demonstrat ct fementale alco acetic i lacie tnt deters 6 ‘microrganine specie, cen ct (a penis abraten uot melo Ge calate & {ueterior sa sor proces de serilzare Apes in evden mature infecionh & oor bola vimir de mite pec sa ror Sl ale omutl 5 ale animale ‘Louis Pusearadescopr sl aplict pen prin ow vaccinate cu micoorpaainas ‘Memuno sua Inttvate, Prin ste 1 Pastext a ich contovenels twora genera pentane conform casas. tnt aa wee ca nee veatone stm gota dt mater presi, Robert Koch (63-1910), mesic geonan, ponte conser tntemeietoral bacterologlel modem dari Irae sle peru puneres a punt acer bwctrologe (siliars trl penu examiares trasepcl invader ‘ior de cular slide im practi inl bce). Reber Kach& decent ‘cfd wbeteulog, denamit bai! Koch preci si vison! hole, Pokaee esr at Heale asp specifi infect micobiere, Kosh frulssh ele wel posts cae pour mumele,eferioae a rgiea, bend nel inet Lowi Paster Robert Kec a gue progres pid al miroiloiel nit ‘in pope escopei et prin formar dee care ra remet a fnl Tt i performane site, ‘ine romdn sau emarat Victor Babes los Canaczino. ‘Victor Babe (1854-1926), mee snatome-puog aun a cece de tiobolopeplecind de a sl topological proces necios De mune ‘ssn legate o eri de cere aspect baceine rami macrossie het tire aes ns), ne micbaceior, dein cnr increment Uo arene Dabex Neat sapere a des ol pet Ue pote dit ge! Ballet ta aspen ior Bl seis "iso Babes ete Curl primal watt de Bcterologie medical dn fame: os to dane Fei, Fantom ot Fis anger sos nts” gr A.V. Cone V. Babes. Flin Alan, 18, Pas 1 info ria insti le ces mee in Rove, fat care pot mle 9 oii prinele erste de pens ttre eo a a. an Chota (1863 (618) mec Format ist Pew din Pi ‘a beratent eli Meviion, «contin cee aches imine everlete a aqofuphit wile agete ale taprlol ters 200 In Posen hth satin, bwciose » foment, nods fa usta sosiowea antfolerca st BCG. tna in Lateral . de Medica sperma pe ee cond In cada ach de Mesa dn Bair po “nls aes pos arts ont 1921) 4 eg cers ear ls reminese oder de cabo Pile vi eras late doa regusivegetal animal pin tn 186, ‘ing Haeckel eopune rep Prt ren ice lee fzanisle oiee 5 Drea cre tonics dere alg, fae peat fle "1987 Chaton pope sive el Prods in soar Cle, ojneite fag) st roca (tot alae albus vera hin se pe ‘irene de mice ssimtora att.) ‘Toto 1 Carcat al eeor rosa ieuceiole Thenee —[__ Ceewearon —_] Tases ie Ti me tera ee recente nae race sa TT A seon58o ‘ie ‘aa mal (o-sapua woleculs ADN | (numa arate pes sibincnem) sper pai wae ae even ical Gain Tips [sore iene eae =a 708. 5S Porte cellar) rezone aban aco (Gorin pepdogcan) | animale. pez Ia place ear Dine procaine sunt considerate ac pare: Eabaceia, Arusha Cyanbactra Attacecerin coins tpl prinitvé de roa ev propo ‘metpoene, hale enee termoxcicie Cyanobacerilenle veche rp ab Alper amsvera eft adeviteprocaite.Restl de procaine 3 ‘Achaea 3 Cyanbictra fo ate in Eater ‘Bacieilernt orgie i de diners reds alee dnt sings ell de ppc are pn vine deca frmenza doo celle noi ence ‘uces pac ubsceaicde 9 CMamydie i Riskeie eae se deosetee de et ‘eter pin ensues lie pin prensa nse4, Morfologia $1 structura celulei bacteriene Dimes bills ueas sbint iii ew ea ibe 9 de cee trates lor se poste numa ca ator icrosopah ‘Ore de lee ale celalelr bacterin aimensone, forma, BAI, ‘otis, icine, spr, cael) pot fp in eviera Income oe. Feit wiles stn ai ieee neces flostea mcosopa eto, ‘Still morfloget 9a sutra normale ale ceo face pe cul tn wi dezvote pe me voile Im condi opie de pl tempera sh. acta Dimensiunea bactorilor Dimensunes baci se mama miro (yn=10 eu). | vmod otigut tacts a densi ne 03-LO}m prosine «3-6 nngine cu vari i fnctie de spin, rma basen mesial de curd wi vista ‘ati Inca mai vec ttre meni iar dect ele canctersice ‘psi Varin al diners ace se costal in afte pelea cince ca ‘Smareierene mecanerlo de ptere x oguisul pads 9x eventaleor patos bit dp forma capetelor ‘oom Bae uti) “este Fusobacteam fesifome) ‘mine (Cornehacerim diene) ‘he pe (Bac cera) Corot “hacent ot alunite imermedire te coc si bail (Pasteurella, Bardtlle persis Brac) Vitint ‘hater erie sib forms de irgla an sunk (Vio ‘ee) :Sa ra oes ee eee wi eeose Clk — —— — vim gy sat NP Spirochete WV ya Figura. Foro bcerior ‘Yarns fot Bato Se cman seen ond x petra meres Gruparea bactorilor Mota de spare «tact, nen arctic ae, gen fais tucson ese In fics de retren Ina filer plan occesve de Avan de eninacllle fice de rain wie ‘Gad slanule sacceave devine sont paralele se pt frma preci rumite diplose (Sreporacuspreemoaise. Netsers mening) dplbasit (Rletuela sp) sa lan de lang vara - srepisnl (Steptoe 5p) sk Stet (Bails saci seu fame de V, M,plit—fore cae se proc sur mica de ahqeere aclu iee en fa! de eel (Corpebacenum ‘apkene, ! ‘ca jvconeo ae Toe tn dot pani pependiclar venue gripe cowiitdn&chle tee (Mrococi agen) ar dchdvzoes fae oT ptanat pepe elt an cob de celle (Seca, pla te au ca ela asi repute Baca. ‘Onna ese consti atean gr de ali tna get denoitpi Ielcuren cu fit ses sufi scene di ule fai. ‘las pent prop aononsc frat in ma ate odne nee Teste kourgansn ee denit_prin douk envi, Innate ‘ateriteue sntissaoganiams, rl curio gels erent Tra meologiea (de exemple pen bai cil, pena a tii >Miacoen per tac eda lp Latobaclisa wo me lel te pina: Exerc dea Esher, Patewelle dea Pasta Al dil cut ec inci fie cows (6, Stapilococos aueas su Step Guerra | leet) -Ccatan oS 7Nocona Actinomyces sn miei mai svamate dst Mcbride aera cla ta veh forma forme cealae pres Dinte scinoniceele sopeicue Srepomyces si Mcromanenport nit cae repo prin so apersal su coi, Des that! nat 0, Pt cetanine rile an lecele po nn ahs sare Caco ae Nocudi pate forme silat | Spain ‘Sueptomyees a imponarya medias ma es dtr fate mute in Se nt rater de ance, sci et Paes Fone unicellre, Baer aricelalare sant ere (csi bc et aoe i) ome helio pi), open amet liga necra n ichese (Richer Covel eae be in geal Cy. Pacis nh detract ec de wos ona libre. Majrisies butrilorpnogen pnts om Ic pt din ses : enuate es imparans medicals sunt gripe dps clones Gra Pear ici Grm-gaiv stad In psc oan mod cies -Eecterchs tater nde ae ‘Saimoele * Mlcoplaanele eget oon ‘amt ogmime plygmorte pte de perce cca, Se noms Ua foe sea ATP prin fn Is ell atau pin keep {lecsai Enis pute fr toh neces wade macerated rear rae Folie sacl | hiro A ox fomeaca pn seston eae molec de pi Sepia ves eae AT. (Cale fesfcetalnei cate prez mama aun mi gop debater nd cig tus ub mol de ATP perro lec de cor xa Tne cee pac ale metabolism hus am let sens sn sun nero comps ered seni sche wee ee o e at i 3 ee er eee cr iipaiee iets ae an cane at Seer eet deatoisma quite es ee Peer cs ae due cd oe a a Rae nner ea eoey bers Sra Sete = oe a en see Ae eee eee [ao omg ema ahs - seyatla e e rats eat rte st tole Ecce a ae em i x tcl phi ia oe a ee er eee anon ca eae oda Spon ted angles arco mo et lil ae ts 2 fa a se Sods cole ee ee nn oo He REAR RSNR| Metabolismul aminoacizitor Derradesasiamcifr se price i Inspates gap ais pn i desaminie area for rest de decree special nota Sine aninosciafr i eas tot ese asin eo ei de cs ce pin alta Emden Meyer! sen enoptotn,sicl Resse Dey ve, dhru [Femara] Metabolismul bazeior purinics si pirimidinice Bazeleprnkc pimp 1 one de ven ca te de carbon Sopa trols accep ena egtese- Ars hace na se Con iN ‘Solera baaeor pine are oc la ftp toate npn vt pia 8 omc atom, Seca tae mince ef in car Metabolismut pide sti degradezi ie vin ipsa extracel In ple ai ies Fusflpdle sunt deseo de inte. Asa so Saad pa CoA pin eae nti Krchs Sintra silor pai w resizeana pin dos sri wna; acti CoA et tate eye 7 Sshema 4.1. Cile metabolic Emde. Metro i Enner- Douro Cilia cox pote Anton co cna de 8 dpi oka de catenin. Gye ee me inmate pine seamen cl Reeve pret aon eames asi fret amit se fen Ge tne fafa ast stl samp cy sa el in eens cote tae AD! Lnlecigenei ppc mute vine se gncvopecve afl oe gee ie contested caren wren cane, od sme lle. O ae a tne ene teat caer nt he, ceo osha mcie rere arse nea ‘Gomez E cat we 0 petite motel de 25x10, coe a0 i eee ef em er eg (ate ae rece conga inc tancane Onda) Replewea comozomulal. ADNu crmovonls epia eononn unt sm senicnserval¥. Cale complemen wpe cond coo cf ae se asaneza eae compemetis pn polineza ena alr mete. Seve de tu cats efor se i gen enor ele ete mnie, acs ctenn mie ee sin ape etna ow fot tan Rele dace sl a frmera 5. Genetica bacteriana ‘Genetic stain de fenomene de an: erehaten 6 aii Eres, tepenina copuiioes pamelor vil de 2 anit seconde siacterl dsinetve const staat ip. ir variable iene 9 vera mare nn uns mi generat rin hinhurenercarscee ce spt meen ete ‘hon gouge islege tliat formate gneve aml mpm cae esi royenn oun cartel pcre ergs le mies Ereditatea bacteriana ine tnlerle helcoiae ear desta cu hell dle origina, La SC Toualiutea derinaflor geet ai wl rganan consttec geome! MBewes ao viers de 750 preci de bate pe scunds fcais opicae, ee nga «+ corer cape pus les detriment cre Slices ce «nthe curmnesoane plsnie-se poi infra rede meee + i TIS can nent 2B : & = ¥ pa rca Gromozomul bacterian Comoaopl aserian ee © matomolecld wie dé ADN cu 0 eae eter de 109 clos angie de 1100-180 micron. O cell bce Mina font a cate de cere cone wn commzon da 6 tga inuipizan cv ets de visi eae a mare, cual monde ce@oaomior eve (2 Sitratoleouet ADN cont uran oobi eixreiza de doo {Sr olmeleore complemenare est ite tmpreant preg ‘ufoger ine url vec gt re forest ramal tae ei Hae ae gas charan (6.0). O secwa te bed: peo cama cae Mien penta caine Goserat nia ae nance Gers anes ‘Spleens serena de pe licen ‘nelomalia fees ese soca deca ail ule, de secrete tear sotte, Col ges te const tlt ove de el ze ae) ae oie un name amos Few replues ematona sa see ol pain 30 & pine * 8+ protine de esc ansumblaracomplesa iii + roteine de spesfcie:pesoneraa 8 RNa + potine do replica: prias gi ADS plimeraz I Rolossins, ce neep Eimecs rs ngimes lanl ptilet Bt oe nec Serge teh a AON oy cel ee mas plane manasa Mr eon Elomentele extracromozomale Plitnidele st cleneote eitneropgzamale sortie in ADN saa Moca blu caemrd de ADN, ciculr sovaem ae dou eeu de relic. soon. eu ganda Nr an nde ell eae rea elas un lc pen o od ear ae prose pti init (iad ses uit repleor ay opine epic "Shacom erence dea gs ei stu sed de ina plea up oc si reaet iis replica ete tnt esas). cere oiee de ADS rou scien ataite a mens stops 8 $e rode pai se de ize cell Replace eromoeornet pie fun sa idecionals In fone Ge cal de mei cca baeona pot sa corse fentestctsh genetic (comoz—m, factor se tava ec for pn hai To nasa in. Pin eco Se nelege oat dependent de ep Functia cromozomului Comorian path proxi 3108 perechi de cet, ee mpiritn segment cae mgmt deri ee de iow Infra gente «ADR eterna n carl process de ita | a preienelorcar ae nen doa ape principle: Fanssieea infra genet i ‘AD inten ARN oelager (ARN) tracer, in cae mesa et decode ‘proud Horo cova ce determi sevetaaricicizor itn ant plpeptii Fovl informal geese ete tesa bisection, den atu be roene sisal ves {ivewtral proce de woscire ARN polinereza formes un sing polbooenid mumit ARN, flasind ADN ca mace ARN pein o sve acted coplanar wel eaten a db elix ABN. ‘Nino sum scva pe cle ezimalca aol anfer ao moecla specifics nla ARN water (ARNO, Fear tel de moles a aon capt | ‘Boje aus complemenre tiple oe taze dep ARN la cela colt Tipo geet. Tipe de Daze de ye ARN Se novete codon pet eh tin, z “ARN i ARN vin npreen a supra itonomi Fecare ARN triplet metic completa ge ARS ainsi pe cre port TSE ee neni! precedes alee ARN Ribose ied dest TKtNn pipet crepe secenial pnd ce toa moleeln de ARN = favsrid i seven crepinatoue de aminoai. ACES res veaslaie Fina 32 foment tre aTerm oro on pn ace a st stdin nee Si ce: ees AD oat now ws. ADM fmt, cel Wine uktRDNdewrineomeznelsstqonhy hy cuml ADS thes na rie oc ‘Consens. ee Aan eminence cep She tease een eee ease ee ee lind mara facts Ar a co Way ea ionceeies coment unr nl sso ef tC ue a main Ginga. Ls Besec Gon... mca ot eeeenan ce en ene —ovmemenna puormapetel erp oee ae Fleey ie eokteiamednts achat sere ia ADN le repo fam hele Rahat mses ADU cea helo Sa fm ei ADK ery pene de ADN Uc mcm eters evil tondomannl Tn atleast ceng ce ara Transductia ‘Waser emai geet do cei ak in tai cee snus onic ; "ath gl acerca) tina cae bse eco a dass eh setae se Canoe seacomh pcan iii duc sas caro gh eget Evol aan vet st a ch fi ace ve map, er ce He ett it ‘win mace chimes) prea -de degrades pin Q re © ® © escis eeea ae 3s i Ms ie Re Mota ace wn carter span i fte ape in oie cella pon actin vce man din waa celles. eee hacteriene n vine ‘Sn ma ma cromovomi mapa se produce nai rs ge a eneia dine © elae ete oisluge nefind sfc de mutate, Moises ewe ‘iat nao at ce dos steps complement. Lago etic rere erst de ine prin expres Transferul do material genetic $i recombinaroa tt ei weed poe eit. i pn cnn tafe ones 8 arog Taser de mae ‘Beran oe twtr donor tata vce, agrent ater Seac mans tmp aan e ABN eer sg ie ps3 Uae ys sm sie cel re ore “Pane ao goer dn Soe ap cave agar ace se acer au ese se nai ner col nse h Pecunia pevei al donors ene lpia eso ‘Transformarea fn proces ansformai srl de aerial otic pode ‘Revomentt astra a fs evident pei prt daa tn 1928 de cae Gr in curl experejlor In legates cu pages prewnococu. Ace ect Voherh ch mole set tapak events, Crh caps, nepaoget four, cocomien ov cular de prewmocoe cael, disest pint ering monreaysecl Expliaba fot gsi mal div de che Avery Cay Me Leos fsa) Cala ates ae pon ups un mina de iii! prota st eolueae ca un fg ic, amulinds ses drying cell La ede pe genom aceran bavenfau! ‘Tiare mail gee re s4 esse iu de cell reepoe neces prezenis pe sprit cen a ee ee re ee ria a eG oe ae [Seer ener Oa oe al Be Caer ces ey osteo et aren ner icaoae | eee eaten ee eee acen ape merneraemmcantrige tnt anaes eae crecea een ati SEL etc oN romeo Ment Sen fname wee tal eTaeiar ite aan ate era ei MMe ar waite a ei Si ea cy a ‘Conjugarea Fats psc cna et en psa Mpa SNe es tle no Grasp, lng I tere Gra posite ‘Recombinaea cerns ee defn ifm sou na zest gsin “La bacleriile Gru negative multe din plasmidele. pe care le poate sunt Benelox dupa schimbares de material ueceic inte, doi. cromoznani. cage ak cue canea e pea s ee ascii corm pesos af Reconbiara ez in cee. pur de ansfr pene: sores, = <> SE en a tahinte an Un pce = Teen 'ADN donor dea ysl ADS acceptor asl c cle do fee ‘ot allacete. ADNel accept exe deface, entng See Rie ree me = | ADN inlecuit ain ADS al acepion eve deceips pin ending Tsai pone fi pws wlll Reuniace (Becta or rt shes tun gadis = ms ir menbie "spin" pasos pn en oa sonicahe in prince tit moe uae ements ranapozabile. Feorenul de anslcare conn capacitaea wnor CED "ADN tine defies pa aw sur salt enone 2 a ter eee ean ‘ iment ose cea ent en) 9 ae Nc gon gr ne aed ph om ah seen tetra a plaid! pe coir aac a nt tore r Scam eaeeoass “Tapani ent sevens ar de ADN, coin sau a mie gone, ‘nel din cet wage ta iia gro eda coi ale cles seven enteric ‘Tranpoia combina recombinare cu replcaen, Secreile de inseie se ‘gi tonal mae exemple In acess oles ria nen lose inerope connie nhitand expinarsceloale gee, Spot pee In calvl severelor de isen ene de ecombinare elit igre ‘ele din como, Rep. once man ulin de eine cite tense ‘pottieso copte routs inser lalncl™ fin endevain genom. suite tei umes gona srctrala. Love psc caer tia tel gee sterile se names operator. fn unele cont etla predic po Siopsmaice mum repeson. Cid un opestr se lesgh de. tment fnciuala exe impeican 9 predoe_ ARN et sel acivataO so fe gete spa wnat cone! cporional_de un iar operas nance Fete moll rear ete corns deo Be elt, [ADNol sin lavodis ella Moines ve rele In capacnes cll oe fois chic ADN-o! fel incit ace ou fai ee sea eae ADNul nei mesa species a Adetozeeo sa cosine ella acters en cre fosomat ste ino pny Seale lot in pocuceres boon, etna a angel, combi" 6 6. _Actiunea factorilor fizici si chimici asupra bacteriilor rea proces, elemeatle cxignale_wanspozable saan Gene de areca. Gene de replat, Geos cine dling statis ‘ ‘Specific de guad2. Teer ue material genetic ae le mai ales Ig 4 8 ere “pees agutiind uno speck rude. Spe Strotifes ADN lt oye i el ‘pica ma ialates msroorgmnior Bfectal becteriowatic we define cy scthnes de opie a destin reveci tectal tacteicid cons im ismeiea boveilor Fesomenul ei evento eas se doreas anne cosine nome de enlnilese care ad ea po price Moieses ADN sli ae lo prin scunea enor mfize care pro ats depart sce pera materiale respevive cin ene pie de inert Spmifsinea do ganda istses puraniees de materi genetic sain Clonses moleclatt & ADN-ul, Nas pte + DN genoa wc a RN ie SA ROL dam cc ‘Aalzaftcol sci ADN epost festa pi “emits seve’ de erih de ise it ADNE “Spaces des sini 20 aul ole eevenie ADN; “Seactute e clon moleslarADN Tose acne east prt se pod nt mal el gee, cu ie i EE Sree cenit yacveiceave conde i alcworpaistelor fate pe ANGER pil, aco, cit ests, “Amigo exe whi chinict sv scape tetcida sa ich eu toi relay Fe, ceva ce petite aslgita loa Clonarea moleclars cop umitarl ee AADNoleste up raperte deo ant vines ftagnentele su iodase un wear plasma sau genom vil Cag in rafomce, vector exe avoda in ella gad nares ost relics ‘ups eplicrea celle vectors aaeara vet ss posh ‘Ave tehied ete denunita in med ots" eholgie AD Pe i z ‘Accenl sibs chinice poste aon 4 stnetc so deziafstan tn conn, od de nae np deca. Actes factor ic gi chimit sup nero depnde de: esi sabi forma de exitens-vegeava tah mortal na de eters, hel de Tce s medi cael nono, Actes fio i cum ee min ic cei stn contact det ou cere exe verde aca Dee st ‘cosine nature egunice compere pi pata, cine mate sale et fe oct zt chim pt ations airs hited act apse aicrobiene. Este un fenonen reverstil pin tnisplaea ssemeet bation se procedel acre microns 1, fmm wove Tee si chinie. [a sod osefre age ich Gane oom aspea terior aut, cla, ta rade rset resign eccrine amet i ica G2 BSC pe plnde de timp varie exe» se onser ate nde 3 ano pro amen Peeeee ienyertr mp sing wow pt de pena: ‘ala (8-15 96 la 85°C, secs ice 045s tT. 78'C 1. Caldu ‘en a pen apecia eft

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Se ebiieat brows {anteloa ara mpc eo, pre. ine soup cu co hn rie mel (SoM) faege cx msec 00% peas cones 1 pom ple (Sites nares Naser eon) ee aibatrin sani ow wos ani yen pes pl ca Sede pe intrest tae (8 "Slat d cape ae cone anion Tle futnice i inconpone nt sl enna xen measeg Pere wsece ‘Ficiselor, spel, ciel, puriull sia incaperto Ca aniseptice, dervatele clone Roose taneetong seem are eee ee ee ree Sacco ee ars eer enserearee Scrat ern Sitceeeame paperencracs Se eet fp eieca rere nenee pr ierthtagl tng io secon earner ceeneras Ee aeoerorer: ant Sa cs ne ho nh cer ae gig eile gl Paige pees ar ae are lone touncirea is cers eae eae fear ec a ssn ema ©) Substantole oxidante ‘oz p oxigen persngansu pty naive bare cxiden pai ere oi. Son ghee devin pla me“col ec en repr! asf 6 meine Patra few za . ear beer ee] esp to pe = hess alia een ae eee |=] =] po ann eo yet ani” Jeon [er] Te ders ote flout tn coneraie de 2.5% pk — aa Er "Rivals - compos atid» ar atone . [insure] =] =] = at (streptococ, stafilococ) ses uilzat pentra aseptizarea plagilor, [tenet | | t ie Feats foes ss] tarsi fli sina [Chex [ox fe] + hah a cee oa a cl sonia a |e pa fa > fez fen mi cationic | meer pene Sian Eee mee tn am C Irexaclorofen, 5 [oe sauce > ati ost aaaon pees [cies fea | | fureeewmmewils [eit ri Sees] > pa ere TORT agen ae +] — Jhexactorofen, fioxic pt. celulele] ee a eal ee etc i “enol, Ripe iitant ft pgeene [ose | ea enti Sie ee = Boe aee sala ee per eam icon) oan fem a [ores | etengenit cationici ioxieate tisular ee cca |— ewe jm une oa | |clorhexidina, iodofori Jdermita prin wt ee cg me fom ot ee feats fet tn pmeie at — sas | fi seen — i fs voce omeee [Sra Fetus scones iguana; Pac nla pe viral sabe 7. Substante antimicrobiene Prine observ ape ntercinit ive dot mooie dint ce lone fea deroles cel apart a Paseo ‘Concept de sniboaanininpovs owas) fo subi tn 189 de 2 nel Ville pet defies an ete elite jes ‘eis cd nnn cent de De nace ence eins een ewan Ince ear eae Ih 1929 cd Aleander Plein, mec aeroloe eg, observ inch rote wet eu de wale de cae Pesan rtatam Meabeint cu ace subi prod ences cea oft “dew ils. Datta iter eae de nals peee ipa el etoe fine de cinerea penis cents deve depen pee ak monde mae sprog de cere ang-aneran pin conta deol Chale "nace pevionl In 193, un christ german Dog etn evden ‘ota unui colorat set 5, pon sort pea a a 1908. Procol data activites snibccing competi le sen suleii(efnlamie).Safemidee sun prince ane ice Glste Ih pofista tamed ein bacene la ot ide 195, ace tte lunidle de tated sant sbsiven ai i nani wr wu ise ale sate co ine aniotan: vos pect al Pecilium grief, Oxteri9%9)sueplmcng it al Stptomyes grisea Wakeman 9s), cloxonta © pee de um seremoniun Bot), saa in cae ei efor coe a inplsont crete aes pod aol angie iste, ei ele din. Antoun ste de anes iain, mbt a vor fn aces, capil opewee dervoles baat csings mioegatmele sik veal tne aor fansna gx Chiniterapiele ainiretene sit sean prepae sbtese care eae an wpa eseroransnle cai abel Sasi shine nfo amc se, op an 2 fo adh eto sor nictorpnane dtc Sat Pepe steak so char analog al cea cue mu apa In nue lasfeae ceito a chipioeraice, los ‘Sint cure stincroan a oi tnveraeate ler fers team subwante atime Exist ms te inae de uiare net es ‘LOriginea substanielor a namaste gh (pails, Kain set SSiseceten tems) = ep aa eri iad er ur ese ir tert hin) ‘Gap de sess rte en (see cine pin sine, 2.Fetl ati tered i rots nares bet PPR hess! ya tcetlorin ie faa ever ncn ti) <_ Stem per bringin cone see gr menenis metas pute ale get Cel Sranenesa srk comic) ‘3Specarl de active aga ip iio sin po a en ah i ‘Rg Up petunia caine poco eam po eaegxt peti Sep cineyecmin tn ian pnt spi rib es site, ceil, retina! perclinel sesotoa ‘fap cee) 4.Surctartchimica mii tia pein ceo) “Thorpe oii etn ann ai) “erases (eeaccian, dx ili) “uals (cron, sta mice) “Treommie (Incomes cldicnn) ‘asinine (ina api) + tule ei Pesctlon ) tenia Nonny, -Pecaspenclna Eta Seronmetpnciig easing f mimeensline mpi oxi cxton : “Shino (sil ean, inidiai (cloeinnro) etna (vanconiing,geouvng letra) Delp (ptm, bcicnn) uopeniines mel, sbi pera aslansacneanainocinay, nai, nofonai,cipoforsinn) cami in i inssuactan (Une) eciniiavlal Ter, Uipeeneal | roa] aes Gita Cxnesin Nines ctor Getesia | Carin | postvieseep caro, Getinein | Gxttoat_ | Sxemomtctionttaces Ceewin | Caaegicn | Sepierma Cerin ol Kyte, Poteas inti (Gaia | ar pin ave po aa po Giorin | Cehrom |detemcetn Gets’ Janel | Nate pte acs ram eras Seeaiveneat Hen ‘Ekebacer sp, Pts inl oy ‘Sees wie Sag Se atten peste da pvr etna ‘Atv ls pease isi ‘agi (caus | {ver asp nee Gam] 6ren encima wel was Sey = Bore acre es ere a i cae eee Se ee ee am ens “Actiune pe mali bacill Gram: Joctam si un lat lateral, set a os care rere — feo Be feces Sears = phy Canes ee ocr cabot Paaervginoss. * Se : joes abe eee ore peaten | Heer Aeiipeoit ‘Ao 8 amnepeniciene aa : za eee an i ee ToT Pen, RatH mond eK a OSC N= cHcoOH Tor poy poate ee see ees, aia see peel car. ‘Alsace pens sb wanpon at primera cela, 1 fahtores See prec. {ine inter eloe cc. ‘Mecenisme de atiune a substanjslorantimicrobiene 1. lnhibarea sinteei pereteluj cesar Bares ners gem tie oma ert de med cies Spor pow cela bosentan! Screen mn tie Secu icapacrais Naw) ee on ‘Sigg sane Rpts pets nace te a (Sl pete pon rec de usp « eel an Belcan 2elbet seb ams Dei pin © (empeicing )aevsoona ane alee aro sede servant sen ints gre ea pid eben abet fatamane pet earn es Senipeiin ee cis p act rp mmc te | mesa, apts nemo Sec Gamaepaeimenagssog unk poee pase, oc Gan psi coi otter bce! pedi ei a iio ep) ile odie last va feu ss shine spec roel makes eastlsnencuate a nt line einen a aiiaten gui enoxinelpenisiagescin VY) ‘olin rexnent la etlactaseze:meelna oxi, Teicine ev pect arg amp, anoxic eaetsli eia ‘Plies dre ear pecine! nega, pati 2 Sr fo in insearentnpena a province), ca tenia “ o1 sce de pein inp de 34 suas ia continare ca bz de ap lege pitied" penislin Binding prot PRP). PRP ae Senay eee ise om roa ret cease tters nemesis etree 2s ciate sree ce og te MME cin mi Cre il echoes he SIDS pr Min out fate mar at NE ron resource bat eee er ae Scenes fea tee cy er enti kM enn ee nrc ea eee 2 cee eetirer aire sete a te are ne, me nM oer seen nad ne ae Sm creetnr rec rt ee eet MR Ss ett ree iy seem aneciencee strana Some ne = aoe ee re ° a ‘Autti fist ne sons Me sede pce Ry anima ce iy ieee Soe re ema ORC AN chet, - Geet Me ee aa ’ sn nee ean cng ee es a ‘cooH ‘epinuriloe mericigae 3 actvitatea enzimelar autolitice, a. foes ree a. oe a Ses eps ewes SEE wna see on I tate otis ops aeati lsx ceereeae MUEfaceo n araa aa es perc aa eee ene Eo eg ae e Sete ene cine sma cu ee basen, reine la rs lnarasele Gr Figur 72. 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