a GnRH agonist, which acts by

inhibiting gonadotropin
secretion

used in the palliative treat

ment of advanced prostate
Leuprolide cancer as well as the
treatment of benign uterine
diseases.

may cause side effects

such as hyperglycemia
and increased serum
levels of testosterone.

competitive inhibitor
of 5α-reductase

used in the treatment of benign

Finasteride prostatic hyperplas
ia

may cause side effects such as

Androgen inhibitors decreased libido and sexual

dysfunction.

an androgen receptor blocker which blocks

the action of dihydrotestosterone on te
stosterone receptor
Cyproterone
used in the treatment of acne,
hirsutism, and excessive sexual
drive

an antifungal agent which inhibits

gonadal and adrenal steroid synthesis
Ketoconazole by inhibiting cholester
ol side chain cleavage.

androgen receptor blockers which block the

action of dihydrotestosterone on tes
tosterone receptors and inhibit the
synthesis of new proteins in prostate and
prostate cancer cells.
Flutamide

usedin the treatment of inoperable prostate

cancer in combination with GnRH analogs.