Girijananda Chowdhury Institute of Pharmaceutical Science Girijananda Chowdhury Institute of Pharmaceutical Science

B Pharm 4th Semester, 1st Sessional Examination, May - 2022 B. Pharm 4th Semester, 1st Sessional Examination, May - 2022
Sub: Medicinal Chemistry-I Sub: Medicinal Chemistry-I
Paper Code: BP402T Paper Code: BP402T
Time: 1 hr FM: 30 Time: 1 hr FM: 30
Answer the following questions: 1×10=10
1. Answer the following questions: 1×10=10
a) Which of the following doesn’t have catechol ring in its
a) Which of the following doesn’t have catechol ring in its structure? structure?

i. Acetylcholine ii. Adrenaline i. Acetylcholine ii. Adrenaline

iii. Norepinephrine iv. Dopmine iii. Norepinephrine iv. Dopmine

b) The starting compound for the biosynthesis of Adrenaline is- b) The starting compound for the biosynthesis of Adrenaline is-
i. L-Tyrosine ii. L-Tryptophan i. L-Tyrosine ii. L-Tryptophan
iii. Histidine iv. L-Leucine iii. Histidine iv. L-Leucine

c) Which of the following is selective α2 agonist? c) Which of the following is selective α2 agonist?
i. Oxotremorine ii. Methacholine i. Oxotremorine ii. Methacholine
iii. Darifenacin iv. Clonidine iii. Darifenacin iv. Clonidine

d) Which of the following drug is a β3 agonist? d) Which of the following drug is a β3 agonist?
i. Methoxamine ii. Mirabegron i. Methoxamine ii. Mirabegron
iii. Metaraminol iv. Mazindol iii. Metaraminol iv. Mazindol

e) Which of the following is a mixed α & β blocker?

e) Which of the following is a mixed α & β blocker? i. Labetalol ii. Esmolol
i. Labetalol ii. Esmolol iii. Nadolol iv. Acebutolol
iii. Nadolol iv. Acebutolol
f) Which of the following drug is used as anorectics?
f) Which of the following drug is used as anorectics? i. Fenfluramine ii. Formoterol
i. Fenfluramine ii. Formoterol iii. Salbutamol iv.Salmeterol
iii. Salbutamol iv.Salmeterol
g) ……………..is used as uterine relaxant.
g) ……………..is used as uterine relaxant. i. Ritodrine ii. Phenylbutazone
i. Ritodrine ii. Phenylbutazone iii.Adrenaline iv. All of the above
iii.Adrenaline iv. All of the above
h) The α2 receptor is responsible for…………..of blood vessels. h) The α2 receptor is responsible for…………..of blood vessels.
i. Contraction ii. Relaxation i. Contraction ii. Relaxation
iii. No effect iv. Both i) & ii) iii. No effect iv. Both i) & ii)

i) ………………..is a selective β1 agonist. i) …………….is a selective β1 agonist.

i. Phenylephrine ii. Dobutamine i. Phenylephrine ii. Dobutamine
iii.Ritodrine iv. Phenoxybenzamine iii.Ritodrine iv. Phenoxybenzamine

j) Which of the following is a sympatholytic drug? j) Which of the following is a sympatholytic drug?
i. Tolzoline ii. Ergotamine i. Tolzoline ii. Ergotamine
iii. Sotalol iv. All of the above iii. Sotalol iv. All of the above

2. Answer the following questions (Any two): 2×5=10

2. Answer the following questions (Any two): 2×5=10
a) Write the biosynthesis of adrenaline.
a) Write the biosynthesis of adrenaline.
b) Distinguish between Sympathetic and Parasympathetic
b) Distinguish between Sympathetic and Parasympathetic
neuron.
neuron.
c) Classify Sympathomimmetic drugs.
c) Classify Sympathomimmetic drugs.

3. Answer the following questions (Any one): 1×10=10 3. Answer the following questions (Any one): 1×10=10

a) Discuss the catabolism of Norepinephrine alongwith a) Discuss the catabolism of Norepinephrine alongwith
reactions involved. reactions involved.
b) Write the synthesis of Salbutamol and Propanolol and b) Write the synthesis of Salbutamol and Propanolol and give
give the medicinal use of both drugs. (5+5=10) the medicinal use of both drugs. (5+5=10)