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    Mihaela Georgiana
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    This document discusses the production of tablets (comprimatelor) in pharmaceuticals. It covers the classification of excipients used in tablets and the tablet manufacturing process which includes drying and mixing powders, granulation either through dry or wet methods, drying granules, compression into tablets, quality control testing of tablets, storage, and packaging. Example tablets are provided for Aspirin, Paracetamol, and Canesten Gyn 3. The document is divided into chapters covering general topics, excipients, official tablets, tablet preparation methods, and examples of pharmaceutical tablets.

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    This document discusses the production of tablets (comprimatelor) in pharmaceuticals. It covers the classification of excipients used in tablets and the tablet manufacturing process which includes drying and mixing powders, granulation either through dry or wet methods, drying granules, compression into tablets, quality control testing of tablets, storage, and packaging. Example tablets are provided for Aspirin, Paracetamol, and Canesten Gyn 3. The document is divided into chapters covering general topics, excipients, official tablets, tablet preparation methods, and examples of pharmaceutical tablets.

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    © All Rights Reserved
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    4 views2 pages

    Cuprins

    Uploaded by

    Mihaela Georgiana
    This document discusses the production of tablets (comprimatelor) in pharmaceuticals. It covers the classification of excipients used in tablets and the tablet manufacturing process which includes drying and mixing powders, granulation either through dry or wet methods, drying granules, compression into tablets, quality control testing of tablets, storage, and packaging. Example tablets are provided for Aspirin, Paracetamol, and Canesten Gyn 3. The document is divided into chapters covering general topics, excipients, official tablets, tablet preparation methods, and examples of pharmaceutical tablets.

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    © All Rights Reserved
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    of 2

    CUPRINS

    INTRODUCERE ................................................................................. pag.4

    CAPITOLUL I GENERALITĂȚI................................................. pag.5

    CAPITOLUL II CLASIFICAREA COMPRIMATELOR ȘI


    EXCIPIENȚI........................................................ pag.7

    2.1. Substanțele medicamentoase și excipienții


    întrebuințați la prepararea comprimatelor....... pag.7

    2.2. Excipienți folosiți la prepararea


    comprimatelor....................................................... pag.8

    2.2.1. Excipienții diluanți................................................. pag.9


    2.2.2. Excipienți absorbanți............................................. pag.9
    2.2.3. Excipienți aglutinanți (lianti sau adezivi) .... pag.9
    2.2.4. Excipienți dezagreganți (dezintegranți)............... pag.11
    2.2.5. Excipienți umectanți.............................................. pag.12
    2.2.6. Excipienți lubrifianți............................................. pag.12
    2.2.7. Excipienți coloranți................................................ pag.13

    CAPITOLUL III COMPRIMATE OFICINALE ÎN F.R. X.......... pag.14

    CAPITOLUL IV PREPARAREA COMPRIMATELOR....... pag.20


    4.1. Uscarea, pulverizarea și amestecarea
    pulberilor............................................................... pag.20

    4.2. Granularea............................................................. pag.20

    4.2.1. Granularea pe cale uscată...................................... pag.21


    4.2.2. Granularea pe cale umedă..................................... pag.22

    4.3. Uscarea granulatelor............................................. pag.23

    4.4. Selecționarea granulatelor.................................... pag.23

    4.5. Comprimarea......................................................... pag.24

    4.6. Controlul comprimatelor...................................... pag.24

    4.7. Conservarea comprimatelor................................ pag.26

    4.8. Ambalarea comprimatelor................................... pag.26

    CAPITOLUL V EXEMPLE DE COMPRIMATE


    FARMACEUTICE............................................. pag.28

    5.1. Aspirina……………………………………… pag.28


    5.2. Paracetamol...................................................... pag.30
    5.3. Canesten Gyn 3................................................. pag.31

    CONCLUZII ............................................................................ pag.33

    BIBLIOGRAFIE ............................................................................ pag.34

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