P: dermatology outpatient

I : low vitamin D serum level

C: high vitamin D serum level
O: vitiligo

Clinical question : in dermatology outpatient, is low vitamin serum compared with high vitamin
D serum level has higher vitiligo?

A. Are the results of the study valid?

1. Did the study address a clearly YES, relation between vit D and
focused issue? vitiligo
2. Did the authors use an appropriate
method to answer their question?
3. Were the cases recruited in an
YES, clear defined of vitiligo
acceptable way?
4. Were the controls selected in an
YES, from healthy population
acceptable way?
5. Was the exposure accurately
YES, vitamin D serum level
measured to minimise bias?
6a. What confounding factors have the
authors accounted for?
6b. Have the authors taken account of
the potential confounding factors in the
design and/or in their analysis?
B. What are the results ?
7. What are the results of this
Table 2
study?
8. How precise are the results ? Table 2
9. Do you believe the results ? YES
C. Will the results help locally ?
10. Can the results be applied to
the local population?
11. Do the results of this study fit
with other available evidence ?