Professional Documents
Culture Documents
A. Acute inflammation
B. Chronic liver cirrhosis
C. Nephrotic syndrome
D. Monoclonal gammopathy
10. Which of the following conditions would correlate best with the presence of distinct
oligoclonal bands in the γ-zone on CSF protein electrophoresis?
a. Multiple sclerosis
b. Multiple myeloma
c. Bacterial meningitis
d. Myoglobinemia
11. When a protein is dissolved in a buffer solution that is more alkaline than its pI and an
electric current is passed through the solution, the protein will act as:
a. An anion and migrate to the anode
b. A cation and migrate to the cathode
c. An anion and migrate to the cathode
d. An uncharged particle will not move
12. Which of the following conditions would correlate best with an elevated serum total protein
with high levels of both albumin and globulins?
a. Dehydration
b. Myocardial infarction
c. Glomerulonephritis
d. Liver cirrhosis
13. Which of the following urine total protein results would correlate best with a patient with
nephrotic syndrome?
a. Normal
b. Lower than normal
c. Higher than normal
d. Similar to levels in CSF total protein levels
14. Isoelectric focusing is used to phenotype α1-antitrypsin deficiencies. When protein is
electrophoresed, it migrates to which of the following?
a. The site there the pH is the same as its pI
b. The site whe the mass of the protein correlates with the pI
c. The site where the protein’s net charge exceeds the pI
d. The site where the protein’s net charge is less than the pI
15. A CSF-serum albumin ratio of 9.8 was reported. How is this best interpreted?
a. The ratio is in the normal range for the patient
b. The blood-brain barrier may be compromised
c. It is biologically impossible to achieve this value
d. This is diagnostic of fungal meningitis
16. Which of the following CSF proteins would be measured when investigating active
demyelination in multiple sclerosis?
a. CSF-serum albumin ratio
b. A1-antitrypsin
c. Myelin basic protein
d. Immunoglobulin G