San Beda College

COLLEGE OF NURSING
P.O. BOX 4457 1005 MANILA, PHILIPPINES TELEFAX: 735-6011 to 15 Loc. 4131

DRUG STUDY
Generic Name: Clindamycin Trade Name: Cleocin Route of Administration: PO, IM, IV Pregnancy Category: B Name Drug Class Mode of Action Indications/ Contraindications CLINDAMYCIN ANTIInhibits bacterial I: >Infections INFECTIVES protein synthesis caused by sensitive by binding to the sstaphylococci, 50S subunit of streptococci, the ribosome. pneumococci, Bacteriodes, Fusobacterium, and other sensitive aerobic and anaerobic organisms. CI: >Contraindicated in patients hypersensitive to drug. >Use cautiously in neonates and patients with renal Dosage: 300 mg capsule q6 Available Stock: 75 mg/5ml, 150 mg, 300 mg Adverse Reaction Nursing Health Teachings Considerations CV: >Obtain > Advise patient to take Thrombophlebitis specimen for capsule form with a full GI: Nausea, culture and glass of water to prevent abdominal pain, sensitivity tests esophageal irritation. vomiting, before giving first >Instruct patient to diarrhea dose. notify prescriber of Hepatic: Jaundice >Monitor renal, adverse reactions such Skin: hepatic, and as diarrhea. Maculopapular hematopoietic rash, urticaria functions during Hematologic:eosi prolonged nophilia therapy. >Observe patient for signs and symptoms of superinfection.

or hepatic disease, asthma, history f GI disease, or significant allergies.

San Beda College

COLLEGE OF NURSING
P.O. BOX 4457 1005 MANILA, PHILIPPINES TELEFAX: 735-6011 to 15 Loc. 4131

DRUG STUDY
Generic Name: Metronidazole Route of Administration: PO, IV Name METRONIDAZOLE Drug Class AMEBICIDES AND ANTIPROTOZ OALS Mode of Action Direct acting trichomonacide and amebicide that works inside and outside the intestines. Its thought to enter the cells of microorganisms that contain nitroreductase, forming unstable compounds that bind to DNA and inhibit synthesis, causing cell death. Trade Name: Flagyl Pregnancy Category: B Indications/ Contraindications I: >Amebic liver abscess >Intestinal amebiasis >Trichomoniasis >Bacterial infections caused by anaerobic microorganisms >Bacterial vaginosis CI :> Contraindicated in patients hypersensitive to drug. >Use cautiously in patients with history of blood dyscrasia, CNS Dosage: 500 mg TIV q8 Available Stock: 375 mg, 500mg/100ml, 500 mg Adverse Reaction CNS: headache, seizures, fever, vertigo, ataxia, dizziness, syncope, irritability, depression, weakness, insomnia CV: edema, flushing EENT: rhinitis, sinusitis, pharyngitis GI: nausea, abdominal cramping or pain, stomatitis, epigastric distress, vomiting, Nursing Considerations >Monitor liver function test results carefully in elderly patients. >Give oral form with meals. >Observe patient for edema, especially if hes receiving corticosteroids: Flagyl IV may cause sodium retention. Health Teachings >Instruct patient in proper hygiene. >Tell patient to avoid alcohol and alcohol containing drugs during and for at least 3 days after treatment course. >Tell patient he may experience a metallic taste and have dark or red-brown urine.

disorder, or retinal or visual field changes. >Use cautiously in patients who take hepatotoxic drugs or have hepatic disease or alcoholism.

anorexia, diarrhea, constipation, dry mouth, metallic taste GU: vaginitis, darkened urine, polyuria, dysuria, cystitis, genital pruritus Respiratory: upper respiratory tract infection Skin: rash

San Beda College

COLLEGE OF NURSING
P.O. BOX 4457 1005 MANILA, PHILIPPINES TELEFAX: 735-6011 to 15 Loc. 4131

DRUG STUDY
Generic Name: Furosemide Route of Administration: PO, IV Trade Name: Lasix Pregnancy Category: C Dosage: 40 mg/ tab TID Available Stock: tab 20mg, 40mg, 80mg, 500mg, oral 10mg/ml, 40mg/5ml, inj. 10mg/ml Adverse Reaction Nursing Considerations >To prevent nocturia, give PO and IM preparations in the morning. >Monitor weight, blood pressure, and pulse rate routinely with long term use and during rapid dieresis. >Monitor fluid intake and output and electrolyte, BUN, and carbon dioxide levels frequently. Health Teachings > Advise patient to take drug with food to prevent GI upset. >Inform patient to take drug in morning to prevent need to urinate at night. >Advise patient to immediately report ringing in ears, severe abdominal pain, or sore throat and fever.

Name FUROSEMIDE

Drug Class DIURETICS

Mode of Action A potent drug that inhibits sodium and chloride reabsorption at the proximal and distal tubules and the ascending loop of Henle.

Indications/ Contraindications I: > Edema >Hypertension

CNS: headache, dizziness, weakness, restlessness CI: >Contraindicated in EENT: blurred patients or yellowed hypersensitive to vision drugs and those GI: abdominal with anuria. discomfort and >Use cautiously in pain, diarrhea, patients with nausea and hepatic cirrhosis vomiting, and in those allergic constipation to sulfonamides. GU: nocturia, polyuria, frequent urination Hepatic: hepatic dysfunction, jaundice

Metabolic: dehydration, hypokalemia, hyperglycemia, impaired glucose tolerance Skin: purpura, dermatitis

>Monitor glucose level in diabetic patients.

San Beda College

COLLEGE OF NURSING
P.O. BOX 4457 1005 MANILA, PHILIPPINES TELEFAX: 735-6011 to 15 Loc. 4131

DRUG STUDY
Generic Name: Oxacillin Route of Administration: PO, IM, IV Name OXACILLIN Drug Class PENICILLIN Trade Name: Bactocill Pregnancy Category: B Indications/ Contraindications I: Oxacillin is indicated in the treatment of infections caused by penicillinase producing staphylococci which have demonstrated susceptibility to the drug. Cultures and susceptibility tests should be performed initially to determine the causative organism and its susceptibility to the drug. CI: A history of a Dosage: 250 to 500 mg IM or IV every 4 to 6 hours Available Stock: tab 125 mg, 250 mg, 500 mg, Inj. 750mg/ Adverse Reaction > fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; > diarrhea that is watery or bloody; > fever, chills, body aches, flu symptoms; >easy bruising or bleeding, unusual weakness; > urinating less than usual or not at all; >severe skin rash, itching, or Nursing Considerations >Patients should be counseled that antibacterial drugs including Oxacillin for Injection should only be used to treat bacterial infections. Health Teachings >Take the medicine with a full glass of water. >Oxacillin should be taken on an empty stomach, at least 1 hour before or 2 hours after eating a meal.

Mode of Action To reduce the development of drug-resistant bacteria and maintain the effectiveness of Oxacillin Injection, USP and other antibacterial drugs, Oxacillin Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

hypersensitivity (anaphylactic) reaction to any penicillin is a contraindication. Solutions containing dextrose may be contraindicated in patients with known allergy to corn or corn products.

peeling; > agitation, confusion, unusual thoughts or behavior; or > seizure (blackout or convulsions).

San Beda College

COLLEGE OF NURSING
P.O. BOX 4457 1005 MANILA, PHILIPPINES TELEFAX: 735-6011 to 15 Loc. 4131

DRUG STUDY
Generic Name: Vessel Due F Trade Name: Sulodexidum Dosage: 1cap OD Route of Administration: PO, IV Pregnancy Category: C Available Stock: cute cases 1 amp 10-20 days once daily followed by 1-2 cap bid 30 mins before meals for 60-90 days. Chronic cases1-2 cap bid 30 mins before meals for 60-90 days. Name VESSEL DUE F Drug Class ANTICOAGULANT, ANTITHROMB OTICS AND FIBRINOLYTIC S Mode of Action Inhibits coagulation by attacking several sites of the coagulation system. Its effect is dependent on the presence of antithrombin III, an alpha 2globulin whose activity is augmented by heparin. The heparinantithrombin complex Indications/ Contraindications I: Vascular pathologies w/ thrombotic risk, transient ischemic attacks & cerebrovascular disease, peripheral vascular insufficiency, diabetic retinopathy, MI, retinal vasal thrombosis. CI: Hypersensitivity to sulodexide, heparin & heparin- like products. Diathesis Adverse Reaction GI disorders: nausea, vomiting, epigastralgia. AMP: Pain, burn, hematoma at the site of injection. Nursing Considerations >Assess patients for signs of bleeding and hemorrhage (bleeding gums; nosebleed; unusual bruising; black, tarry stools; hematuria; fall in hematocrit or blood pressure; guaiac- positive stools). Notify physician if these occur. >Monitor patient for Health Teachings

inactivates factors IXa, Xa, XIa and XIIa, and prevents thrombin formation. Furthermore, the complex reverses the effect of already formed thrombin. In high concentrations, heparin also inhibits thrombocyte aggregation. D

& hemorrhagic diseases.

hypersensitivity reactions (chills, fever, urticaria). Report signs to physician >Subcutaneous: observe injection sites for hematomas, ecchymosis, or inflammation. >Monitor platelet count every 2-3 days throughout therapy. May cause mild thrombocytopeni a, which appears on the 4th day and resolves despite continued heparin therapy.