ORTHOPOXVIRUS LECTURIO

Orthopoxvirus is a genus of large, brick-shaped, double-stranded DNA viruses. Several

clinically relevant species exist, including variola virus (the cause of smallpox), monkeypox
virus, vaccinia virus, and cowpox virus. Transmission varies depending on the species but
can be through contact with infected bodily secretions, skin lesions, or fomites. Smallpox is
the most severe disease, presenting with constitutional symptoms and a diffuse, well-
circumscribed maculopapular rash that progresses through an evolutionary process that
results in scarring. Smallpox is associated with a high mortality rate. Monkeypox presents
similarly but has lower mortality and is associated with lymphadenopathy. Vaccinia and
cowpox produce milder disease with localized lesions acquired from direct skin-to-skin
contact. These infections are diagnosed with the aid of PCR, serology, viral culture, and/or
electron microscopy. There are no known treatments for these diseases, and management is
generally supportive. Vaccination has led to the eradication of smallpoX
*A DIFERENCIA DE OTROS VIRUS
 References
1. Virus taxonomy: 2019 release. (2019). International Committee on Taxonomy of Viruses.
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Emergence and reemergence of vaccinia-like viruses: global scenario and perspectives.
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8. Friedman HM, Isaacs SN. (2020). Variola virus (smallpox). In Mitty, J. (Ed.), UpToDate.
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viruses/monkeypox
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from https://www.who.int/news-room/fact-sheets/detail/monkeypox

POXVIRUS

- VIRUS DE LA VIRUELA
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o ES LINEAL DE DOBLE CADENA

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