OverVIew Notes (4) Related Modules

254 Motecular 43
Biology

CHEMISTRY OFNUCLEOTIDES
Chemistry of nucleic acid 00:01:25

Tuo types of nucleic acid:OUA and RNA.

The nucleic acids are made up of nucleotides.
The nucieotide is made up of
nitrogenous base (purines f pyrimidines)
Pentose sugar Cribose, deoxyribosel
Phosphate group.
ntroqenus base t pentose sugar=
Neucleoside.

Purine bases 00:03:30

a heterocucic ring structures with nitrogen positions ot ,3,7,9.

Purines Adenine and quAnine.
minor purines : Xanthine, hupoxanthine, and uric acid.

635975a7dt22be2e5370d693

N Purine

o amino purine a amino b Oxopurine

NH.

Açtive
space H

Adenine A) Euanine ()

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Overview Notes (4) Related Modules

43 Chernistry of
Nucleotides

Purimidines :
Single heterocyclic ring structure with nitrogen positions at i,3.
Pyrimidines :
uraci CeNA onkyj), thymine CONA only, cytosine.

3
635975a7df22bepe5370d693

a oxo 4 amino
a,4 dioxo a, 4 dioXO S
methyl pyrimidine Pyrimidine
Pyrimidine
CH,
H

Uracil (w Thumine (T) Cytosine )

both DNA ana RNA
RNA only CN only

00:10:29
Nucleoside formation

Purine
BNqlycosidic bond between Clofpentose
Feedback
D sugar N9 o purine.
Ctof pentosesugar {NIof
pyrimidine.
Pentose sugar.
' position- ribose.
OH groupis present at a,
3' position- ceoxy space
Active
If OH group is present onky in
ribose.

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Overview Notes (4) Related Modules

256 Molecular 43
Biolbgy
Nucleotide formation 00:14:12

Addition of PO4 qroup byester bond to the sc atom:

Nucleoside monophosphate.
Further Po4 qroups are attached by acid anhydride bond
# an acidanhydride bond is broKen, enerquis released
tapubhuyan39332 @gmäil.com Purine

N9
Acid onhdride bond esher bond
CH
-Po,

a' a Pentose sugar

OH OH

Dinucleotide formation 00:16:37

The tuo nuckeotides are joined by a 3 to S phosphodiester

bond :Between the 3OH aroup to the SPO4 aroup.

The nucleotide with a free functional qroup at position :

First nucleotide Chead endJ.

The nuclectide with the ree unctional aroup at 3 position:

Last nucleotide Ctail end].

These functional qroups are ionizable - exhibit Polarity

written
By corvertion, the base sequence of nucleic acid is
Feedback
D from s to 3!.
Nitrogeneous base
PO,-CH,

a'
Pentose Nitrogeneous base
OH CH
3 to S
Phosphodiester Ypentose
bond OH

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Overview Notes (4) Related Modules

43 Chemistry of
Nucleotides

Ribonucleotide and deoxy Ribonucleotide 00:26:4g

Nitrogenaus Nucieosde Ribose Deoxy nuckeosicde

base nucleoside monophosphate
monophosphate
Adenine Aclenosire Adenosine Deoxyadenosine
monophosphate moncnophosphate
Guanine RAAOSine Guanosine Deoxy euanosine
monophosphate monophosphate
uridine uridine Deoxy uridine

Hypoxanthine tapubhuya
inosine NaR3O332@dmäil.com
Inosine Deoxs nosine

monophosphatemonophosphate
Xarthine Xortto- Xarthosine Deoxs xanthosine
sinemonophosphate monophosphate
Cutosine Cytidine cytidine Deoxyeytidine
monophosphate monophosphate

D
Feedback

space
Active

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